SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xez'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1xez HEMOLYSIN
(Vibrio
cholerae) 		5 / 12 THR A 447
VAL A 448
SER A 398
GLY A  79
ALA A  72
 None
 1.09A 1jg4A-1xezA:
undetectable		 1jg4A-1xezA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 1xez HEMOLYSIN
(Vibrio
cholerae) 		4 / 7 PRO A 383
PHE A 258
PHE A 256
SER A 405
 None
 1.02A 1lqtA-1xezA:
undetectable		 1lqtA-1xezA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 1xez HEMOLYSIN
(Vibrio
cholerae) 		4 / 7 PRO A 383
PHE A 258
PHE A 256
SER A 405
 None
 1.02A 1lquA-1xezA:
undetectable		 1lquA-1xezA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1xez HEMOLYSIN
(Vibrio
cholerae) 		4 / 7 VAL A 610
VAL A 711
LEU A 590
LEU A 608
 None
 0.89A 1pthB-1xezA:
undetectable		 1pthB-1xezA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1xez HEMOLYSIN
(Vibrio
cholerae) 		4 / 7 SER A 505
ALA A 506
SER A 507
SER A 494
 None
 0.92A 2i91A-1xezA:
undetectable		 2i91A-1xezA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1xez HEMOLYSIN
(Vibrio
cholerae) 		4 / 7 SER A 505
ALA A 506
SER A 507
SER A 494
 None
 0.93A 2i91B-1xezA:
undetectable		 2i91B-1xezA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z71_C_PNVC904_1
(PENICILLIN ACYLASE)		 1xez HEMOLYSIN
(Vibrio
cholerae) 		5 / 10 GLY A 620
GLN A 600
THR A 314
ASN A 598
GLU A 289
 None
 1.26A 2z71A-1xezA:
0.0
2z71C-1xezA:
0.0		 2z71A-1xezA:
19.23
2z71C-1xezA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 1xez HEMOLYSIN
(Vibrio
cholerae) 		4 / 6 PRO A 453
TYR A 503
VAL A 461
THR A 509
 None
 1.04A 3tneA-1xezA:
undetectable		 3tneA-1xezA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1xez HEMOLYSIN
(Vibrio
cholerae) 		4 / 8 LEU A  96
VAL A 142
VAL A  80
TYR A  78
 None
 1.01A 4puoC-1xezA:
undetectable		 4puoC-1xezA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1xez HEMOLYSIN
(Vibrio
cholerae) 		4 / 8 LEU A  96
VAL A 142
VAL A  80
TYR A  78
 None
 1.01A 4pwdA-1xezA:
undetectable		 4pwdA-1xezA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 1xez HEMOLYSIN
(Vibrio
cholerae) 		4 / 8 LEU A 550
THR A 542
ARG A 535
LEU A 571
 None
 1.21A 4qknA-1xezA:
undetectable		 4qknA-1xezA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_B_1LDB501_0
(CYTOSINE DEAMINASE)		 1xez HEMOLYSIN
(Vibrio
cholerae) 		5 / 12 LEU A 290
ILE A 388
GLU A 189
GLU A 135
LEU A 139
 None
 1.21A 4r88B-1xezA:
undetectable		 4r88B-1xezA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1xez HEMOLYSIN
(Vibrio
cholerae) 		6 / 12 VAL A 711
VAL A 708
ILE A 701
ILE A 616
GLY A 675
VAL A 680
 None
 1.43A 4y8wC-1xezA:
undetectable		 4y8wC-1xezA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 1xez HEMOLYSIN
(Vibrio
cholerae) 		3 / 3 ASP A 605
SER A 636
TYR A 609
 None
 0.91A 5glmA-1xezA:
0.7		 5glmA-1xezA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1xez HEMOLYSIN
(Vibrio
cholerae) 		5 / 12 VAL A 610
VAL A 711
LEU A 590
LEU A 690
LEU A 608
 None
 1.09A 5iktB-1xezA:
undetectable		 5iktB-1xezA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1xez HEMOLYSIN
(Vibrio
cholerae) 		4 / 5 TYR A 666
GLY A 641
GLY A 628
LEU A 662
 None
 0.91A 5jlcA-1xezA:
undetectable		 5jlcA-1xezA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1xez HEMOLYSIN
(Vibrio
cholerae) 		4 / 5 ILE A 146
PHE A 144
ARG A  75
THR A 399
 None
 1.30A 5z84N-1xezA:
0.0
5z84W-1xezA:
undetectable		 5z84N-1xezA:
20.74
5z84W-1xezA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 1xez HEMOLYSIN
(Vibrio
cholerae) 		4 / 8 LEU A 590
VAL A 708
LEU A 659
ILE A 616
 None
 0.72A 6cb4A-1xezA:
undetectable		 6cb4A-1xezA:
20.71