SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xf1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 8 THR A 763
ASP A 803
GLY A1017
TYR A 960
 None
 0.90A 1bu5B-1xf1A:
undetectable		 1bu5B-1xf1A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_A_CAMA502_0
(CYTOCHROME P450-CAM)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 6 LEU A 645
VAL A 628
VAL A 602
ASP A 604
 None
 0.99A 1dz4A-1xf1A:
undetectable		 1dz4A-1xf1A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_B_CAMB502_0
(CYTOCHROME P450-CAM)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 6 LEU A 645
VAL A 628
VAL A 602
ASP A 604
 None
 0.97A 1dz4B-1xf1A:
undetectable		 1dz4B-1xf1A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 5 PHE A 838
GLY A 836
THR A 886
PHE A 834
 None
 1.40A 1icvA-1xf1A:
undetectable
1icvB-1xf1A:
undetectable		 1icvA-1xf1A:
14.04
1icvB-1xf1A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		3 / 3 ARG A 882
GLY A 746
ASP A 747
 None
 0.57A 1kf6A-1xf1A:
undetectable
1kf6B-1xf1A:
undetectable		 1kf6A-1xf1A:
21.19
1kf6B-1xf1A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		5 / 7 GLY A 714
PRO A 311
PHE A 709
ASN A 600
ASN A 601
 None
None
None
ACT  A1107 (-4.1A)
None
 1.27A 1oniG-1xf1A:
undetectable
1oniI-1xf1A:
undetectable		 1oniG-1xf1A:
8.78
1oniI-1xf1A:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T85_A_CAMA422_0
(CYTOCHROME P450-CAM)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 7 LEU A 645
VAL A 628
VAL A 602
ASP A 604
 None
 0.96A 1t85A-1xf1A:
0.0		 1t85A-1xf1A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 7 LEU A 645
VAL A 628
VAL A 602
ASP A 604
 None
 0.95A 1t87A-1xf1A:
undetectable		 1t87A-1xf1A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 6 PHE A 838
VAL A 866
PHE A 834
SER A 860
 None
 1.03A 1wrlB-1xf1A:
undetectable		 1wrlB-1xf1A:
7.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		5 / 5 LEU A 479
GLY A 483
HIS A 598
ILE A 707
PHE A 709
 CIT  A1101 (-3.7A)
ACT  A1107 (-3.8A)
None
ACT  A1107 (-3.8A)
None
 0.00A 1xf1A-1xf1A:
70.6		 1xf1A-1xf1A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		6 / 6 LEU A 479
GLY A 483
HIS A 598
ASN A 600
ILE A 707
PHE A 709
 CIT  A1101 (-3.7A)
ACT  A1107 (-3.8A)
None
ACT  A1107 (-4.1A)
ACT  A1107 (-3.8A)
None
 0.13A 1xf1B-1xf1A:
57.6		 1xf1B-1xf1A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRC_A_CAMA420_0
(CYTOCHROME P450-CAM)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 7 LEU A 645
VAL A 628
VAL A 602
ASP A 604
 None
 0.98A 1yrcA-1xf1A:
0.0		 1yrcA-1xf1A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRD_A_CAMA420_0
(CYTOCHROME P450-CAM)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 7 LEU A 645
VAL A 628
VAL A 602
ASP A 604
 None
 0.97A 1yrdA-1xf1A:
0.0		 1yrdA-1xf1A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		3 / 3 TRP A 650
THR A 627
TYR A 564
 None
 1.26A 2a3aB-1xf1A:
2.3		 2a3aB-1xf1A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		3 / 3 TRP A 650
THR A 627
TYR A 564
 None
 1.29A 2a3bA-1xf1A:
2.2		 2a3bA-1xf1A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_B_CAMB1421_0
(CYTOCHROME P450-CAM)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 7 LEU A 645
VAL A 628
VAL A 602
ASP A 604
 None
 0.98A 2feuB-1xf1A:
0.0		 2feuB-1xf1A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 7 LEU A 645
VAL A 628
VAL A 602
ASP A 604
 None
 0.99A 2qblA-1xf1A:
undetectable		 2qblA-1xf1A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDM_B_AGGB1462_1
(INTEGRIN ALPHA-IIB
INTEGRIN BETA-3)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		5 / 12 SER A 182
TYR A 181
TYR A 178
ALA A 131
GLU A 230
 None
 1.42A 2vdmA-1xf1A:
0.0
2vdmB-1xf1A:
3.1		 2vdmA-1xf1A:
19.68
2vdmB-1xf1A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAW_A_CAMA422_0
(CYTOCHROME P450-CAM)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 6 LEU A 645
VAL A 628
VAL A 602
ASP A 604
 None
 1.00A 2zawA-1xf1A:
0.0		 2zawA-1xf1A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAX_A_CAMA422_0
(CYTOCHROME P450-CAM)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 7 LEU A 645
VAL A 628
VAL A 602
ASP A 604
 None
 0.97A 2zaxA-1xf1A:
undetectable		 2zaxA-1xf1A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWT_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 7 LEU A 645
VAL A 628
VAL A 602
ASP A 604
 None
 0.97A 2zwtA-1xf1A:
0.0		 2zwtA-1xf1A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWU_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 7 LEU A 645
VAL A 628
VAL A 602
ASP A 604
 None
 0.97A 2zwuA-1xf1A:
0.0		 2zwuA-1xf1A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		3 / 3 MET A 996
GLU A 977
ASP A 803
 None
 0.67A 3a25A-1xf1A:
undetectable		 3a25A-1xf1A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 4 SER A 202
GLY A 203
GLY A 199
GLY A 194
 None
 0.83A 3bogB-1xf1A:
0.0
3bogD-1xf1A:
0.0		 3bogB-1xf1A:
undetectable
3bogD-1xf1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 6 LEU A 645
VAL A 628
VAL A 602
ASP A 604
 None
 1.00A 3fwgA-1xf1A:
0.0		 3fwgA-1xf1A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 7 LEU A 645
VAL A 628
VAL A 602
ASP A 604
 None
 0.97A 3fwgB-1xf1A:
undetectable		 3fwgB-1xf1A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L63_A_CAMA440_0
(CAMPHOR
5-MONOOXYGENASE)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 7 LEU A 645
VAL A 628
VAL A 602
ASP A 604
 None
 1.00A 3l63A-1xf1A:
0.0		 3l63A-1xf1A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		5 / 12 GLU A 216
GLY A 121
ALA A 222
ALA A 118
GLN A 115
 None
 1.33A 3nmuA-1xf1A:
undetectable
3nmuF-1xf1A:
undetectable		 3nmuA-1xf1A:
17.58
3nmuF-1xf1A:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 5 TYR A1010
THR A1009
PHE A1008
LEU A1028
 None
 1.05A 3qelC-1xf1A:
4.6		 3qelC-1xf1A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		5 / 11 ALA A 760
PHE A 758
ARG A 811
GLY A 796
ALA A 795
 None
 1.05A 3rukD-1xf1A:
undetectable		 3rukD-1xf1A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		5 / 12 LEU A 479
GLY A 708
LEU A 686
GLU A 687
PHE A 709
 CIT  A1101 (-3.7A)
ACT  A1107 ( 4.2A)
None
None
None
 1.22A 3tbgA-1xf1A:
undetectable		 3tbgA-1xf1A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		5 / 12 LEU A 479
GLY A 708
LEU A 686
GLU A 687
PHE A 709
 CIT  A1101 (-3.7A)
ACT  A1107 ( 4.2A)
None
None
None
 1.20A 3tbgC-1xf1A:
0.0		 3tbgC-1xf1A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		3 / 3 LYS A 302
ARG A 393
LEU A 497
 None
CIT  A1103 ( 3.7A)
None
 1.13A 3v4tE-1xf1A:
undetectable		 3v4tE-1xf1A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 7 LEU A 645
VAL A 628
VAL A 602
ASP A 604
 None
 0.96A 3wrhA-1xf1A:
0.0		 3wrhA-1xf1A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 6 LEU A 645
VAL A 628
VAL A 602
ASP A 604
 None
 0.96A 3wrhE-1xf1A:
undetectable		 3wrhE-1xf1A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 7 LEU A 645
VAL A 628
VAL A 602
ASP A 604
 None
 0.98A 3wrjA-1xf1A:
0.0		 3wrjA-1xf1A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 6 LEU A 645
VAL A 628
VAL A 602
ASP A 604
 None
 0.97A 3wrjE-1xf1A:
undetectable		 3wrjE-1xf1A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 7 LEU A 645
VAL A 628
VAL A 602
ASP A 604
 None
 0.96A 3wrlA-1xf1A:
0.0		 3wrlA-1xf1A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 7 LEU A 645
VAL A 628
VAL A 602
ASP A 604
 None
 0.99A 3wrlE-1xf1A:
0.0		 3wrlE-1xf1A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 7 LEU A 645
VAL A 628
VAL A 602
ASP A 604
 None
 0.98A 3wrmA-1xf1A:
0.0		 3wrmA-1xf1A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_F_CAMF503_0
(CAMPHOR
5-MONOOXYGENASE)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 7 LEU A 645
VAL A 628
VAL A 602
ASP A 604
 None
 0.97A 3wrmF-1xf1A:
0.0		 3wrmF-1xf1A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		5 / 9 LEU A 524
ALA A 577
ASP A 576
VAL A 518
ILE A 521
 None
 1.32A 3wsjA-1xf1A:
undetectable		 3wsjA-1xf1A:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZS3_A_ACTA1224_0
(THAUMATIN-LIKE
PROTEIN)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 5 SER A 787
THR A 976
TYR A 978
ASP A 803
 None
 1.27A 3zs3A-1xf1A:
0.0		 3zs3A-1xf1A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 4 SER A 284
TYR A 281
GLY A 286
PRO A 538
 None
 1.47A 4e3aA-1xf1A:
3.0		 4e3aA-1xf1A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 6 LEU A 645
VAL A 628
VAL A 602
ASP A 604
 None
 0.96A 4ek1A-1xf1A:
0.0		 4ek1A-1xf1A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 8 HIS A 734
GLU A 735
GLY A 729
SER A 730
 None
 0.80A 4f93B-1xf1A:
6.0		 4f93B-1xf1A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 5 TYR A 213
GLN A 494
GLY A 493
SER A 332
 None
 1.20A 4fu8A-1xf1A:
undetectable		 4fu8A-1xf1A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 6 LEU A 645
VAL A 628
VAL A 602
ASP A 604
 None
 0.91A 4g3rA-1xf1A:
0.0		 4g3rA-1xf1A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 6 LEU A 645
VAL A 628
VAL A 602
ASP A 604
 None
 0.95A 4g3rB-1xf1A:
0.0		 4g3rB-1xf1A:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		3 / 3 ASP A 576
LEU A 549
VAL A 587
 None
 0.62A 4jecB-1xf1A:
undetectable		 4jecB-1xf1A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KKY_X_CAMX503_0
(CAMPHOR
5-MONOOXYGENASE)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 6 LEU A 645
VAL A 628
VAL A 602
ASP A 604
 None
 0.94A 4kkyX-1xf1A:
0.0		 4kkyX-1xf1A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4A_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 8 LEU A 645
VAL A 628
VAL A 602
ASP A 604
 None
 0.96A 4l4aA-1xf1A:
undetectable		 4l4aA-1xf1A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 6 LEU A 645
VAL A 628
VAL A 602
ASP A 604
 None
 0.89A 4l4cA-1xf1A:
undetectable		 4l4cA-1xf1A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		3 / 3 SER A 649
ALA A 626
VAL A 690
 None
 0.67A 4o2bC-1xf1A:
undetectable		 4o2bC-1xf1A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		5 / 12 LYS A 579
ALA A 572
GLY A 573
ILE A 485
ASN A 484
 None
 1.30A 4obwD-1xf1A:
undetectable		 4obwD-1xf1A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		3 / 3 PRO A 705
VAL A 587
HIS A 613
 None
 0.64A 4pevC-1xf1A:
2.4		 4pevC-1xf1A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		5 / 12 THR A1020
THR A1022
TYR A1010
VAL A1012
LEU A 949
 None
 0.98A 4qynA-1xf1A:
undetectable		 4qynA-1xf1A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		5 / 12 PHE A 456
ILE A 438
ALA A 436
TYR A 369
LEU A 446
 None
 1.32A 4qztC-1xf1A:
undetectable		 4qztC-1xf1A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		5 / 12 THR A1020
THR A1022
TYR A1010
VAL A1012
LEU A 949
 None
 0.92A 4qzuC-1xf1A:
undetectable		 4qzuC-1xf1A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 7 ALA A 515
GLY A 294
ALA A 293
SER A 324
 None
 0.76A 4r1zB-1xf1A:
undetectable		 4r1zB-1xf1A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		3 / 3 THR A 790
ASN A 766
SER A 765
 None
 0.74A 4tvtA-1xf1A:
undetectable		 4tvtA-1xf1A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 7 PHE A 279
ARG A 247
LYS A 283
TYR A 281
 None
 1.46A 4uciB-1xf1A:
undetectable		 4uciB-1xf1A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		3 / 3 MET A 536
GLU A 540
LEU A 544
 None
 0.59A 4v2oB-1xf1A:
undetectable		 4v2oB-1xf1A:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 7 PHE A 692
LEU A 622
SER A 551
VAL A 663
 None
 0.88A 4wnvD-1xf1A:
undetectable		 4wnvD-1xf1A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		5 / 12 ASN A 871
TYR A 870
ASN A 841
SER A 717
GLN A 919
 None
None
CIT  A1101 (-3.8A)
None
None
 1.45A 4xueA-1xf1A:
undetectable		 4xueA-1xf1A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		5 / 12 LEU A 947
LEU A 989
ILE A 964
GLU A1013
LEU A1028
 None
 0.95A 4y0sA-1xf1A:
undetectable		 4y0sA-1xf1A:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		3 / 4 ARG A 214
GLY A 217
GLU A 216
 None
 0.65A 4z2dB-1xf1A:
undetectable
4z2dC-1xf1A:
undetectable		 4z2dB-1xf1A:
20.00
4z2dC-1xf1A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 7 VAL A 866
THR A 863
LEU A 719
VAL A 907
 None
 1.05A 5e4dA-1xf1A:
undetectable
5e4dB-1xf1A:
undetectable		 5e4dA-1xf1A:
12.65
5e4dB-1xf1A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_B_QELB503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		5 / 11 THR A 664
PRO A 666
ALA A 626
ILE A 667
GLU A 700
 None
 1.48A 5ewjA-1xf1A:
4.8
5ewjB-1xf1A:
2.7		 5ewjA-1xf1A:
16.85
5ewjB-1xf1A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		5 / 12 VAL A 518
LEU A 517
VAL A 111
ALA A 577
LEU A 549
 None
 1.15A 5ikrA-1xf1A:
1.1		 5ikrA-1xf1A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 8 THR A 648
TYR A 706
PHE A 606
TYR A 646
 None
 1.27A 5v4vA-1xf1A:
undetectable		 5v4vA-1xf1A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 8 THR A 648
TYR A 706
PHE A 606
TYR A 646
 None
 1.27A 5v4vB-1xf1A:
undetectable		 5v4vB-1xf1A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		5 / 12 ALA A 515
PRO A 516
GLY A 217
GLY A 573
LEU A 471
 None
 1.15A 5wwsA-1xf1A:
undetectable		 5wwsA-1xf1A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 1xf1 C5A PEPTIDASE
(Streptococcus
pyogenes) 		4 / 4 VAL A 897
GLY A 890
ASP A 889
ASP A 830
 None
None
None
CA  A1109 (-3.4A)
 1.05A 6cjkC-1xf1A:
3.7		 6cjkC-1xf1A:
11.78