SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xfa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 1xfa CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Mus
musculus) 		5 / 12 MET A 645
ILE A 661
THR A 665
LEU A 666
LEU A 610
 None
 1.33A 1eiiA-1xfaA:
undetectable		 1eiiA-1xfaA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1xfa CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Mus
musculus) 		4 / 7 GLY A 391
HIS A 484
THR A 599
ILE A 448
 None
 0.96A 1gtnF-1xfaA:
undetectable
1gtnG-1xfaA:
undetectable		 1gtnF-1xfaA:
16.91
1gtnG-1xfaA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 1xfa CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Mus
musculus) 		3 / 3 MET A 607
VAL A 591
GLU A 583
 None
 0.83A 2x9gA-1xfaA:
undetectable		 2x9gA-1xfaA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 1xfa CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Mus
musculus) 		4 / 7 LEU A 454
ASP A 614
ALA A 613
TYR A 627
 None
 1.15A 3rodD-1xfaA:
undetectable		 3rodD-1xfaA:
25.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1xfa CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Mus
musculus) 		4 / 4 LEU A 541
GLY A 542
GLY A 545
THR A 547
 ACY  A   7 (-4.2A)
ACY  A   7 (-3.3A)
ACY  A   7 (-3.0A)
ACY  A   7 ( 3.1A)
 0.17A 3si7A-1xfaA:
43.8		 3si7A-1xfaA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1xfa CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Mus
musculus) 		3 / 3 LYS A 532
SER A 549
GLN A 552
 ACY  A   9 (-2.5A)
ACY  A   9 ( 3.5A)
ACY  A   9 ( 3.9A)
 0.31A 3si7A-1xfaA:
43.8		 3si7A-1xfaA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1xfa CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Mus
musculus) 		3 / 3 GLY A 542
GLY A 545
THR A 547
 ACY  A   7 (-3.3A)
ACY  A   7 (-3.0A)
ACY  A   7 ( 3.1A)
 0.12A 3si7B-1xfaA:
27.7		 3si7B-1xfaA:
99.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1xfa CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Mus
musculus) 		4 / 5 LEU A 541
GLY A 542
GLY A 545
THR A 547
 ACY  A   7 (-4.2A)
ACY  A   7 (-3.3A)
ACY  A   7 (-3.0A)
ACY  A   7 ( 3.1A)
 0.19A 3si7C-1xfaA:
42.6
3si7D-1xfaA:
43.3		 3si7C-1xfaA:
99.65
3si7D-1xfaA:
99.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1xfa CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Mus
musculus) 		3 / 3 THR A 398
ASN A 443
GLU A 479
 None
 0.67A 3v4tA-1xfaA:
0.8
3v4tC-1xfaA:
0.7		 3v4tA-1xfaA:
22.43
3v4tC-1xfaA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 1xfa CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Mus
musculus) 		4 / 7 LEU A 570
ALA A 566
ASP A 565
VAL A 562
 None
 0.87A 4eyrA-1xfaA:
undetectable		 4eyrA-1xfaA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1xfa CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Mus
musculus) 		4 / 7 ILE A 456
HIS A 609
LEU A 610
ALA A 613
 None
 0.64A 5hrqE-1xfaA:
undetectable
5hrqF-1xfaA:
undetectable
5hrqJ-1xfaA:
undetectable		 5hrqE-1xfaA:
7.73
5hrqF-1xfaA:
10.50
5hrqJ-1xfaA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 1xfa CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Mus
musculus) 		3 / 3 CYH A 434
LYS A 429
HIS A 432
 None
 1.22A 5js5A-1xfaA:
undetectable		 5js5A-1xfaA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_E_SAME501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1xfa CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Mus
musculus) 		5 / 9 LEU A 619
HIS A 620
GLY A 461
SER A 624
LEU A 441
 None
None
ATP  A   1 (-3.2A)
None
None
 1.18A 5o96E-1xfaA:
0.3
5o96F-1xfaA:
0.0		 5o96E-1xfaA:
21.96
5o96F-1xfaA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 1xfa CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Mus
musculus) 		4 / 8 LEU A 468
HIS A 484
LEU A 441
ILE A 482
 None
 0.99A 5v0vA-1xfaA:
undetectable		 5v0vA-1xfaA:
21.20