SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xfb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 1xfb ALDOLASE C
(Homo
sapiens) 		5 / 8 ARG A  60
LEU A  63
ALA A 332
GLY A  29
ILE A  30
 None
 1.48A 1d4yB-1xfbA:
undetectable		 1d4yB-1xfbA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1xfb ALDOLASE C
(Homo
sapiens) 		4 / 4 THR A 206
LEU A 210
VAL A 213
LEU A 217
 None
 0.46A 1fbmB-1xfbA:
undetectable		 1fbmB-1xfbA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1xfb ALDOLASE C
(Homo
sapiens) 		4 / 4 THR A 206
LEU A 210
VAL A 213
LEU A 217
 None
 0.63A 1fbmD-1xfbA:
undetectable		 1fbmD-1xfbA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1xfb ALDOLASE C
(Homo
sapiens) 		4 / 5 THR A 206
LEU A 210
VAL A 213
LEU A 217
 None
 0.49A 1fbmE-1xfbA:
undetectable		 1fbmE-1xfbA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 1xfb ALDOLASE C
(Homo
sapiens) 		5 / 11 GLU A 188
LEU A 271
ILE A 186
TYR A 214
THR A 206
 None
 1.22A 1jomA-1xfbA:
undetectable		 1jomA-1xfbA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1xfb ALDOLASE C
(Homo
sapiens) 		3 / 3 LEU A 210
VAL A 213
LEU A 217
 None
 0.51A 1mz9B-1xfbA:
undetectable		 1mz9B-1xfbA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1xfb ALDOLASE C
(Homo
sapiens) 		4 / 4 THR A 206
LEU A 210
VAL A 213
LEU A 217
 None
 0.62A 1mz9D-1xfbA:
undetectable		 1mz9D-1xfbA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV5_A_65BA600_0
(REVERSE
TRANSCRIPTASE)		 1xfb ALDOLASE C
(Homo
sapiens) 		5 / 10 LEU A 210
VAL A 265
VAL A 187
PRO A 295
LEU A 257
 None
 1.34A 1sv5A-1xfbA:
0.0		 1sv5A-1xfbA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1xfb ALDOLASE C
(Homo
sapiens) 		4 / 5 LEU A  16
GLY A 106
ALA A  20
ILE A  19
 None
 0.86A 2aohB-1xfbA:
undetectable		 2aohB-1xfbA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 1xfb ALDOLASE C
(Homo
sapiens) 		3 / 3 PHE A 145
SER A 301
LEU A  31
 None
 0.73A 2w1bA-1xfbA:
undetectable		 2w1bA-1xfbA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 1xfb ALDOLASE C
(Homo
sapiens) 		5 / 12 THR A 299
GLY A  29
ALA A  25
ALA A  32
ASP A  34
 None
 1.20A 2yvlD-1xfbA:
undetectable		 2yvlD-1xfbA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1xfb ALDOLASE C
(Homo
sapiens) 		5 / 9 GLY A 106
VAL A 105
ASP A 144
ILE A 183
VAL A 109
 None
 1.33A 3fi0M-1xfbA:
undetectable		 3fi0M-1xfbA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1xfb ALDOLASE C
(Homo
sapiens) 		5 / 9 GLY A 106
VAL A 105
ASP A 144
ILE A 183
VAL A 109
 None
 1.27A 3fi0O-1xfbA:
undetectable		 3fi0O-1xfbA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 1xfb ALDOLASE C
(Homo
sapiens) 		5 / 12 GLY A 274
LEU A 271
GLU A 277
ALA A 280
ASN A 283
 None
 1.15A 3kkzA-1xfbA:
undetectable		 3kkzA-1xfbA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 1xfb ALDOLASE C
(Homo
sapiens) 		5 / 12 ILE A 107
ALA A 143
ILE A  19
ALA A  20
GLY A  75
 None
 1.07A 3nxuA-1xfbA:
0.0		 3nxuA-1xfbA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 1xfb ALDOLASE C
(Homo
sapiens) 		3 / 3 GLU A 188
LEU A 271
LEU A  31
 None
 0.77A 3ohtB-1xfbA:
undetectable		 3ohtB-1xfbA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 1xfb ALDOLASE C
(Homo
sapiens) 		5 / 7 ARG A  60
LEU A  63
ALA A 332
GLY A  75
ILE A  30
 None
 1.49A 3spkB-1xfbA:
undetectable		 3spkB-1xfbA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1xfb ALDOLASE C
(Homo
sapiens) 		4 / 7 THR A 260
LEU A 152
ASN A 232
LEU A 271
 None
 1.08A 4ib4A-1xfbA:
undetectable		 4ib4A-1xfbA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1xfb ALDOLASE C
(Homo
sapiens) 		4 / 6 ASN A 283
GLU A 247
GLU A 248
TYR A 244
 None
 1.44A 4mi4A-1xfbA:
1.1		 4mi4A-1xfbA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1xfb ALDOLASE C
(Homo
sapiens) 		5 / 11 SER A  39
ALA A  32
ASP A 110
THR A 125
GLY A 112
 None
 1.48A 4zjoD-1xfbA:
undetectable		 4zjoD-1xfbA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 1xfb ALDOLASE C
(Homo
sapiens) 		4 / 8 ASN A 232
PRO A 231
PHE A 270
SER A 272
 None
 1.45A 5amiB-1xfbA:
undetectable		 5amiB-1xfbA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 1xfb ALDOLASE C
(Homo
sapiens) 		5 / 8 GLU A 190
GLY A 273
GLY A 274
ASP A 194
HIS A 238
 None
 1.43A 5f8yA-1xfbA:
undetectable		 5f8yA-1xfbA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1xfb ALDOLASE C
(Homo
sapiens) 		4 / 8 ALA A 321
VAL A  62
ILE A  47
VAL A  49
 None
 0.83A 5nujA-1xfbA:
undetectable		 5nujA-1xfbA:
13.73