SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xfc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 1xfc ALANINE RACEMASE
(Mycobacterium
tuberculosis) 		4 / 8 SER A 109
VAL A 134
ARG A 228
ALA A 107
 None
None
PLP  A 390 (-3.9A)
None
 1.10A 1dmiA-1xfcA:
0.0
1dmiB-1xfcA:
undetectable		 1dmiA-1xfcA:
23.51
1dmiB-1xfcA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 1xfc ALANINE RACEMASE
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 243
PRO A 240
ASP A 357
ALA A 356
 None
 0.85A 1gxsA-1xfcA:
undetectable
1gxsB-1xfcA:
undetectable		 1gxsA-1xfcA:
21.58
1gxsB-1xfcA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 1xfc ALANINE RACEMASE
(Mycobacterium
tuberculosis) 		4 / 6 VAL A 253
THR A 252
GLU A 349
LEU A 341
 None
 1.13A 1s8fB-1xfcA:
undetectable		 1s8fB-1xfcA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 1xfc ALANINE RACEMASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  37
ALA A  57
VAL A  53
LEU A  65
VAL A 227
 None
 0.91A 1sn5B-1xfcA:
undetectable
1sn5D-1xfcA:
undetectable		 1sn5B-1xfcA:
16.62
1sn5D-1xfcA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 1xfc ALANINE RACEMASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  65
VAL A 227
LEU A  37
ALA A  57
VAL A  53
 None
 0.91A 1sn5B-1xfcA:
undetectable
1sn5D-1xfcA:
undetectable		 1sn5B-1xfcA:
16.62
1sn5D-1xfcA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 1xfc ALANINE RACEMASE
(Mycobacterium
tuberculosis) 		4 / 5 VAL A 143
GLY A 142
VAL A 134
TRP A  88
 None
None
None
PLP  A 390 (-3.5A)
 1.00A 1tkqB-1xfcA:
undetectable		 1tkqB-1xfcA:
4.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 1xfc ALANINE RACEMASE
(Mycobacterium
tuberculosis) 		5 / 9 ILE A 263
ASP A 280
GLY A 266
GLU A 267
ALA A 277
 None
 1.30A 2dtjA-1xfcA:
undetectable
2dtjB-1xfcA:
undetectable		 2dtjA-1xfcA:
20.58
2dtjB-1xfcA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 1xfc ALANINE RACEMASE
(Mycobacterium
tuberculosis) 		4 / 6 PRO A 312
LEU A 326
ARG A 310
GLY A 308
 None
 1.21A 2hs2B-1xfcA:
undetectable		 2hs2B-1xfcA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1xfc ALANINE RACEMASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 215
PHE A 224
THR A 136
LEU A 195
THR A 216
 None
 1.30A 2oipB-1xfcA:
undetectable		 2oipB-1xfcA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 1xfc ALANINE RACEMASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 117
ALA A 163
LEU A 166
VAL A 130
THR A 127
 None
 1.06A 3frbX-1xfcA:
undetectable		 3frbX-1xfcA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1xfc ALANINE RACEMASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 215
PHE A 224
THR A 136
LEU A 195
THR A 216
 None
 1.22A 3hj3C-1xfcA:
undetectable		 3hj3C-1xfcA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 1xfc ALANINE RACEMASE
(Mycobacterium
tuberculosis) 		4 / 7 ALA A 120
ALA A 128
ALA A  99
PRO A  98
 None
 0.92A 4du2A-1xfcA:
undetectable		 4du2A-1xfcA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 1xfc ALANINE RACEMASE
(Mycobacterium
tuberculosis) 		4 / 7 ALA A 128
ALA A  99
ALA A 120
THR A 124
 None
 0.79A 4du2A-1xfcA:
undetectable		 4du2A-1xfcA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 1xfc ALANINE RACEMASE
(Mycobacterium
tuberculosis) 		4 / 7 ALA A 128
ALA A  99
ALA A 120
THR A 124
 None
 0.73A 4du2B-1xfcA:
undetectable		 4du2B-1xfcA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 1xfc ALANINE RACEMASE
(Mycobacterium
tuberculosis) 		5 / 11 ASP A 115
VAL A 130
ALA A 107
SER A 110
SER A 109
 None
 1.11A 4mmaA-1xfcA:
undetectable		 4mmaA-1xfcA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 1xfc ALANINE RACEMASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 195
LEU A 222
THR A 136
VAL A 134
 None
 1.08A 4udaA-1xfcA:
undetectable		 4udaA-1xfcA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 1xfc ALANINE RACEMASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 155
ALA A 158
LEU A 118
LEU A 117
GLY A 125
 None
 1.00A 4xi3C-1xfcA:
undetectable		 4xi3C-1xfcA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 1xfc ALANINE RACEMASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 152
LEU A 114
LEU A 111
PHE A 148
 None
 0.97A 5gs4A-1xfcA:
undetectable		 5gs4A-1xfcA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 1xfc ALANINE RACEMASE
(Mycobacterium
tuberculosis) 		5 / 8 VAL A  67
ALA A  75
VAL A 104
HIS A  90
VAL A  85
 None
 1.07A 5l94A-1xfcA:
undetectable		 5l94A-1xfcA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 1xfc ALANINE RACEMASE
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 341
CYH A 255
LEU A  11
ASP A 292
 None
 0.88A 5mafA-1xfcA:
undetectable		 5mafA-1xfcA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1xfc ALANINE RACEMASE
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 316
THR A 274
ILE A 317
GLY A 315
 None
 1.01A 5nzxA-1xfcA:
undetectable		 5nzxA-1xfcA:
20.69