SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xfj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 1xfj CONSERVED
HYPOTHETICAL PROTEIN
(Caulobacter
vibrioides) 		5 / 10 ALA A 128
VAL A 146
ILE A 159
GLY A 161
VAL A 141
 None
 0.82A 1hsgA-1xfjA:
undetectable		 1hsgA-1xfjA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 1xfj CONSERVED
HYPOTHETICAL PROTEIN
(Caulobacter
vibrioides) 		3 / 3 ASP A 139
ARG A 135
ASP A 185
 None
 0.97A 1vptA-1xfjA:
undetectable		 1vptA-1xfjA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 1xfj CONSERVED
HYPOTHETICAL PROTEIN
(Caulobacter
vibrioides) 		3 / 3 ARG A 252
ASP A  96
ASP A 139
 None
 0.72A 2ejtA-1xfjA:
undetectable		 2ejtA-1xfjA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 1xfj CONSERVED
HYPOTHETICAL PROTEIN
(Caulobacter
vibrioides) 		5 / 11 ALA A 128
VAL A 146
ILE A 159
GLY A 161
VAL A 141
 None
 0.80A 2nnpB-1xfjA:
undetectable		 2nnpB-1xfjA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1xfj CONSERVED
HYPOTHETICAL PROTEIN
(Caulobacter
vibrioides) 		5 / 12 ALA A 128
VAL A 146
ILE A 159
GLY A 161
VAL A 141
 None
 0.87A 2q63A-1xfjA:
undetectable		 2q63A-1xfjA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 1xfj CONSERVED
HYPOTHETICAL PROTEIN
(Caulobacter
vibrioides) 		5 / 9 ALA A  97
ALA A 109
SER A 255
PHE A  24
GLY A 164
 None
 1.38A 2vh3A-1xfjA:
undetectable		 2vh3A-1xfjA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)		 1xfj CONSERVED
HYPOTHETICAL PROTEIN
(Caulobacter
vibrioides) 		5 / 11 ALA A 128
VAL A 146
ILE A 159
GLY A 161
VAL A 141
 None
 0.84A 3ekxB-1xfjA:
undetectable		 3ekxB-1xfjA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_2
(PROTEASE)		 1xfj CONSERVED
HYPOTHETICAL PROTEIN
(Caulobacter
vibrioides) 		5 / 12 ALA A 128
VAL A 146
ILE A 159
GLY A 161
VAL A 141
 None
 0.85A 3el1B-1xfjA:
undetectable		 3el1B-1xfjA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_1
(HIV-1 PROTEASE)		 1xfj CONSERVED
HYPOTHETICAL PROTEIN
(Caulobacter
vibrioides) 		5 / 12 ALA A 128
VAL A 146
ILE A 159
GLY A 161
VAL A 141
 None
 0.86A 3k4vC-1xfjA:
undetectable		 3k4vC-1xfjA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1xfj CONSERVED
HYPOTHETICAL PROTEIN
(Caulobacter
vibrioides) 		3 / 3 TYR A  74
ASP A  96
ASP A 139
 None
 0.91A 3ou6B-1xfjA:
undetectable		 3ou6B-1xfjA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 1xfj CONSERVED
HYPOTHETICAL PROTEIN
(Caulobacter
vibrioides) 		5 / 12 PHE A 209
GLY A 188
ASP A 185
GLY A 190
PHE A 192
 None
 1.21A 3ps9A-1xfjA:
undetectable		 3ps9A-1xfjA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 1xfj CONSERVED
HYPOTHETICAL PROTEIN
(Caulobacter
vibrioides) 		5 / 12 ALA A 128
VAL A 146
ILE A 159
GLY A 161
VAL A 141
 None
 0.89A 3tl9B-1xfjA:
undetectable		 3tl9B-1xfjA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1xfj CONSERVED
HYPOTHETICAL PROTEIN
(Caulobacter
vibrioides) 		5 / 12 ALA A  81
ALA A 128
VAL A  99
ALA A 132
VAL A 142
 None
 1.29A 4df3A-1xfjA:
undetectable		 4df3A-1xfjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1xfj CONSERVED
HYPOTHETICAL PROTEIN
(Caulobacter
vibrioides) 		5 / 12 ALA A  81
ALA A 128
VAL A  99
ALA A 132
VAL A 142
 None
 1.32A 4df3B-1xfjA:
undetectable		 4df3B-1xfjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 1xfj CONSERVED
HYPOTHETICAL PROTEIN
(Caulobacter
vibrioides) 		5 / 10 ALA A 129
GLY A 161
ILE A 159
VAL A  20
ILE A 257
 None
 1.11A 4dqcA-1xfjA:
undetectable		 4dqcA-1xfjA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1xfj CONSERVED
HYPOTHETICAL PROTEIN
(Caulobacter
vibrioides) 		4 / 5 PRO A 207
ASP A 205
ILE A 167
VAL A 174
 None
 1.38A 4hytA-1xfjA:
undetectable		 4hytA-1xfjA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 1xfj CONSERVED
HYPOTHETICAL PROTEIN
(Caulobacter
vibrioides) 		5 / 12 ALA A 128
VAL A 146
ILE A 159
GLY A 161
VAL A 141
 None
 0.82A 4jecA-1xfjA:
undetectable		 4jecA-1xfjA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 1xfj CONSERVED
HYPOTHETICAL PROTEIN
(Caulobacter
vibrioides) 		5 / 11 ALA A 128
VAL A 146
ILE A 159
GLY A 161
VAL A 141
 None
 0.85A 4qgiB-1xfjA:
undetectable		 4qgiB-1xfjA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1xfj CONSERVED
HYPOTHETICAL PROTEIN
(Caulobacter
vibrioides) 		3 / 3 VAL A 210
LEU A 214
VAL A 142
 None
 0.58A 4wq4A-1xfjA:
undetectable		 4wq4A-1xfjA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 1xfj CONSERVED
HYPOTHETICAL PROTEIN
(Caulobacter
vibrioides) 		4 / 4 LEU A  17
ILE A 257
HIS A  22
VAL A  20
 None
 0.96A 4xyzA-1xfjA:
undetectable		 4xyzA-1xfjA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1xfj CONSERVED
HYPOTHETICAL PROTEIN
(Caulobacter
vibrioides) 		5 / 7 GLY A  19
VAL A 120
ASP A 121
ILE A 126
VAL A 127
 None
 1.09A 5ik1A-1xfjA:
undetectable		 5ik1A-1xfjA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1xfj CONSERVED
HYPOTHETICAL PROTEIN
(Caulobacter
vibrioides) 		3 / 3 PHE A 243
ASP A 247
LEU A 253
 None
 0.76A 5uhbC-1xfjA:
undetectable		 5uhbC-1xfjA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJS_A_SALA603_0
(VICILIN-LIKE
ANTIMICROBIAL
PEPTIDES 2-2)		 1xfj CONSERVED
HYPOTHETICAL PROTEIN
(Caulobacter
vibrioides) 		5 / 11 PHE A 236
ARG A 227
VAL A 225
PHE A  24
GLY A 226
 None
ACT  A 272 (-3.0A)
None
None
None
 1.49A 5yjsA-1xfjA:
0.0		 5yjsA-1xfjA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJS_B_SALB601_0
(VICILIN-LIKE
ANTIMICROBIAL
PEPTIDES 2-2)		 1xfj CONSERVED
HYPOTHETICAL PROTEIN
(Caulobacter
vibrioides) 		5 / 9 PHE A 236
ARG A 227
VAL A 225
PHE A  24
GLY A 226
 None
ACT  A 272 (-3.0A)
None
None
None
 1.45A 5yjsB-1xfjA:
0.0		 5yjsB-1xfjA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 1xfj CONSERVED
HYPOTHETICAL PROTEIN
(Caulobacter
vibrioides) 		5 / 12 ALA A 128
VAL A 146
ILE A 159
GLY A 161
VAL A 141
 None
 0.83A 6dh0A-1xfjA:
undetectable		 6dh0A-1xfjA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_0
(PROTEASE)		 1xfj CONSERVED
HYPOTHETICAL PROTEIN
(Caulobacter
vibrioides) 		5 / 12 ALA A 128
VAL A 146
ILE A 159
GLY A 161
VAL A 141
 None
 0.85A 6dh6A-1xfjA:
undetectable		 6dh6A-1xfjA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_0
(HIV-1 PROTEASE)		 1xfj CONSERVED
HYPOTHETICAL PROTEIN
(Caulobacter
vibrioides) 		5 / 12 ALA A 128
VAL A 146
ILE A 159
GLY A 161
VAL A 141
 None
 1.00A 6dilA-1xfjA:
undetectable		 6dilA-1xfjA:
15.35