SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xfk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 1xfk FORMIMIDOYLGLUTAMASE
(Vibrio
cholerae) 		4 / 4 ARG A  58
ALA A  54
ALA A 103
GLU A 101
 None
 0.92A 1e7bA-1xfkA:
undetectable		 1e7bA-1xfkA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 1xfk FORMIMIDOYLGLUTAMASE
(Vibrio
cholerae) 		5 / 12 ALA A 299
PHE A 258
LEU A 314
PHE A 227
PHE A 283
 None
 1.29A 1nw3A-1xfkA:
3.0		 1nw3A-1xfkA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1xfk FORMIMIDOYLGLUTAMASE
(Vibrio
cholerae) 		5 / 12 ALA A 323
ALA A  75
ALA A 312
ILE A 298
LEU A 276
 None
 1.04A 2nyrA-1xfkA:
3.8		 2nyrA-1xfkA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 1xfk FORMIMIDOYLGLUTAMASE
(Vibrio
cholerae) 		4 / 5 PRO A 179
ALA A 130
ASP A 215
ASP A 157
 None
 1.11A 2nyuB-1xfkA:
3.4		 2nyuB-1xfkA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)		 1xfk FORMIMIDOYLGLUTAMASE
(Vibrio
cholerae) 		5 / 10 LEU A  90
VAL A 122
GLY A 136
ALA A  46
ILE A  48
 None
 0.92A 3ekpB-1xfkA:
undetectable		 3ekpB-1xfkA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 1xfk FORMIMIDOYLGLUTAMASE
(Vibrio
cholerae) 		5 / 9 LEU A  90
VAL A 122
GLY A 136
ALA A  46
ILE A  48
 None
 0.99A 3el0B-1xfkA:
undetectable		 3el0B-1xfkA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 1xfk FORMIMIDOYLGLUTAMASE
(Vibrio
cholerae) 		5 / 12 GLY A  64
GLY A 126
PHE A  50
ARG A  94
ALA A 103
 None
 1.13A 3keeA-1xfkA:
undetectable		 3keeA-1xfkA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 1xfk FORMIMIDOYLGLUTAMASE
(Vibrio
cholerae) 		4 / 7 LEU A 255
ALA A  65
ASP A  53
ILE A  93
 None
 0.97A 4eyrA-1xfkA:
undetectable		 4eyrA-1xfkA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 1xfk FORMIMIDOYLGLUTAMASE
(Vibrio
cholerae) 		5 / 12 LEU A 236
TRP A 220
ALA A 197
GLY A 200
LEU A 199
 None
 1.16A 4j7xB-1xfkA:
undetectable		 4j7xB-1xfkA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 1xfk FORMIMIDOYLGLUTAMASE
(Vibrio
cholerae) 		5 / 12 LEU A 276
PHE A 258
ASP A 256
ASP A 157
GLY A 200
 None
 1.11A 4j7xF-1xfkA:
2.2		 4j7xF-1xfkA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1xfk FORMIMIDOYLGLUTAMASE
(Vibrio
cholerae) 		3 / 3 SER A 176
ASP A 306
ASP A 256
 None
 0.63A 4uckA-1xfkA:
undetectable		 4uckA-1xfkA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 1xfk FORMIMIDOYLGLUTAMASE
(Vibrio
cholerae) 		3 / 3 ASP A  89
LEU A 123
GLY A  49
 None
 0.53A 4xmfA-1xfkA:
undetectable		 4xmfA-1xfkA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1xfk FORMIMIDOYLGLUTAMASE
(Vibrio
cholerae) 		5 / 12 GLY A 152
TYR A 248
ILE A 154
ILE A 243
HIS A 195
 None
 1.20A 4xucA-1xfkA:
3.8		 4xucA-1xfkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1xfk FORMIMIDOYLGLUTAMASE
(Vibrio
cholerae) 		5 / 12 GLY A 152
TYR A 248
ILE A 154
ILE A 243
HIS A 195
 None
 1.18A 4xudA-1xfkA:
4.1		 4xudA-1xfkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 1xfk FORMIMIDOYLGLUTAMASE
(Vibrio
cholerae) 		4 / 6 ILE A 322
MET A 326
LEU A 251
ILE A 286
 None
 0.64A 5mvmB-1xfkA:
undetectable
5mvmC-1xfkA:
undetectable		 5mvmB-1xfkA:
13.25
5mvmC-1xfkA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 1xfk FORMIMIDOYLGLUTAMASE
(Vibrio
cholerae) 		5 / 12 ALA A 130
GLY A 136
ASP A 254
ALA A 299
PRO A 179
 None
 1.30A 5zvgA-1xfkA:
undetectable		 5zvgA-1xfkA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 1xfk FORMIMIDOYLGLUTAMASE
(Vibrio
cholerae) 		5 / 12 ALA A 130
GLY A 136
ASP A 254
ALA A 299
PRO A 179
 None
 1.28A 5zvgB-1xfkA:
undetectable		 5zvgB-1xfkA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 1xfk FORMIMIDOYLGLUTAMASE
(Vibrio
cholerae) 		4 / 5 ASN A 155
GLY A  55
HIS A 127
ASP A 297
 None
 1.00A 6gh9A-1xfkA:
undetectable		 6gh9A-1xfkA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 1xfk FORMIMIDOYLGLUTAMASE
(Vibrio
cholerae) 		3 / 3 TRP A 320
ILE A 322
ASP A 321
 None
 0.91A 6i0y7-1xfkA:
undetectable		 6i0y7-1xfkA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 1xfk FORMIMIDOYLGLUTAMASE
(Vibrio
cholerae) 		4 / 4 ASP A 306
ILE A  72
PRO A  69
LEU A  71
 None
 1.33A 6mkeA-1xfkA:
undetectable		 6mkeA-1xfkA:
11.53