SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xfl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AX7_A_SALA1336_1 (XANTHINE DEHYDROGENASE/OXIDAS E)	1xfl	THIOREDOXIN H1 (Arabidopsis thaliana)	4 / 8	PHE A 50 VAL A 31 LEU A 61 ALA A 54	None	1.02A	3ax7A-1xflA: undetectable	3ax7A-1xflA: 6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FVQ_A_ACTA904_0 (TYROSINE-PROTEIN KINASE JAK2)	1xfl	THIOREDOXIN H1 (Arabidopsis thaliana)	3 / 3	PHE A 87 VAL A 97 GLU A 104	None	0.79A	4fvqA-1xflA: undetectable	4fvqA-1xflA: 15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JMN_B_FUAB1101_1 (MULTIDRUG EFFLUX PUMP SUBUNIT ACRB)	1xfl	THIOREDOXIN H1 (Arabidopsis thaliana)	4 / 5	ILE A 109 LEU A 94 LYS A 89 VAL A 60	None	1.19A	5jmnB-1xflA: undetectable	5jmnB-1xflA: 7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6D9H_R_ADNR400_1 (CHIMERA PROTEIN OF MUSCARINIC ACETYLCHOLINE RECEPTOR M4 AND ADENOSINE RECEPTOR A1)	1xfl	THIOREDOXIN H1 (Arabidopsis thaliana)	5 / 10	VAL A 32 PHE A 50 LEU A 105 ILE A 109 THR A 108	None	1.11A	6d9hR-1xflA: undetectable	6d9hR-1xflA: 19.51

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3AX7_A_SALA1336_1","XANTHINE DEHYDROGENASE\/OXIDASE","1xfl","THIOREDOXIN H1","Arabidopsis thaliana",4,"PHE A  50;VAL A  31;LEU A  61;ALA A  54","None","1.02A","3ax7A-1xflA:undetectable","3ax7A-1xflA:6.69"],["4FVQ_A_ACTA904_0","TYROSINE-PROTEIN KINASE JAK2","1xfl","THIOREDOXIN H1","Arabidopsis thaliana",3,"PHE A  87;VAL A  97;GLU A 104","None","0.79A","4fvqA-1xflA:undetectable","4fvqA-1xflA:15.81"],["5JMN_B_FUAB1101_1","MULTIDRUG EFFLUX PUMP SUBUNIT ACRB","1xfl","THIOREDOXIN H1","Arabidopsis thaliana",4,"ILE A 109;LEU A  94;LYS A  89;VAL A  60","None","1.19A","5jmnB-1xflA:undetectable","5jmnB-1xflA:7.90"],["6D9H_R_ADNR400_1","CHIMERA PROTEIN OF MUSCARINIC ACETYLCHOLINE RECEPTOR M4 AND ADENOSINE RECEPTOR A1","1xfl","THIOREDOXIN H1","Arabidopsis thaliana",5,"VAL A  32;PHE A  50;LEU A 105;ILE A 109;THR A 108","None","1.11A","6d9hR-1xflA:undetectable","6d9hR-1xflA:19.51"]]