SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xfs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 1xfs CONSERVED
HYPOTHETICAL PROTEIN
(Nitrosomonas
europaea) 		5 / 12 THR A  89
GLY A  75
GLU A  58
GLY A  57
ASN A 136
 None
 0.96A 1n2xA-1xfsA:
undetectable		 1n2xA-1xfsA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 1xfs CONSERVED
HYPOTHETICAL PROTEIN
(Nitrosomonas
europaea) 		5 / 12 THR A  89
GLY A  75
GLU A  58
GLY A  57
ASN A 136
 None
 0.84A 1n2xB-1xfsA:
undetectable		 1n2xB-1xfsA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_2
(PHOSPHOLIPASE A2
HOMOLOG 2)		 1xfs CONSERVED
HYPOTHETICAL PROTEIN
(Nitrosomonas
europaea) 		5 / 11 LEU A  29
VAL A  20
ARG A 128
TYR A 129
LYS A  15
 None
 1.43A 1y4lB-1xfsA:
undetectable		 1y4lB-1xfsA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_F_5FWF1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 1xfs CONSERVED
HYPOTHETICAL PROTEIN
(Nitrosomonas
europaea) 		4 / 6 GLU A 145
LYS A 142
PRO A 138
GLU A   9
 None
 0.98A 4a7tF-1xfsA:
undetectable		 4a7tF-1xfsA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 1xfs CONSERVED
HYPOTHETICAL PROTEIN
(Nitrosomonas
europaea) 		5 / 12 PHE A  39
LEU A 160
ILE A 157
TYR A 129
ALA A 116
 None
 1.41A 4a83A-1xfsA:
12.7		 4a83A-1xfsA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 1xfs CONSERVED
HYPOTHETICAL PROTEIN
(Nitrosomonas
europaea) 		5 / 12 HIS A 144
VAL A 117
ILE A 118
TYR A 129
ILE A 157
 None
 1.31A 4drhA-1xfsA:
undetectable		 4drhA-1xfsA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_D_RAPD201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 1xfs CONSERVED
HYPOTHETICAL PROTEIN
(Nitrosomonas
europaea) 		5 / 12 HIS A 144
VAL A 117
ILE A 118
TYR A 129
ILE A 157
 None
 1.30A 4drhD-1xfsA:
undetectable		 4drhD-1xfsA:
22.16