SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xg2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 1xg2 PECTINESTERASE
INHIBITOR
(Actinidia
chinensis) 		5 / 12 ILE B  82
ALA B 107
GLN B  50
SER B  40
ILE B  43
 None
 1.24A 1dlsA-1xg2B:
undetectable		 1dlsA-1xg2B:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 1xg2 PECTINESTERASE 1
(Solanum
lycopersicum) 		4 / 7 LEU A 257
SER A 227
THR A 229
VAL A 231
 None
 0.99A 1dvxB-1xg2A:
undetectable		 1dvxB-1xg2A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 1xg2 PECTINESTERASE 1
(Solanum
lycopersicum) 		4 / 6 LYS A 107
ALA A 103
LEU A  71
THR A 102
 None
 1.07A 1ictB-1xg2A:
undetectable		 1ictB-1xg2A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 1xg2 PECTINESTERASE
INHIBITOR
(Actinidia
chinensis) 		5 / 12 CYH B 139
ASP B 132
GLY B 112
ASP B 109
GLN B  45
 None
 1.33A 1oltA-1xg2B:
undetectable		 1oltA-1xg2B:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 1xg2 PECTINESTERASE 1
(Solanum
lycopersicum) 		4 / 6 LYS A 107
ALA A 103
LEU A  71
THR A 102
 None
 1.12A 1tyrA-1xg2A:
undetectable		 1tyrA-1xg2A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1xg2 PECTINESTERASE 1
(Solanum
lycopersicum) 		5 / 11 VAL A 309
ASN A 123
ILE A 122
ILE A 298
LEU A 304
 None
 0.98A 1z11A-1xg2A:
undetectable		 1z11A-1xg2A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1xg2 PECTINESTERASE 1
(Solanum
lycopersicum) 		5 / 11 VAL A 309
ASN A 123
ILE A 122
ILE A 298
LEU A 304
 None
 1.01A 1z11B-1xg2A:
undetectable		 1z11B-1xg2A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1xg2 PECTINESTERASE 1
(Solanum
lycopersicum) 		5 / 10 VAL A 309
ASN A 123
ILE A 122
ILE A 298
LEU A 304
 None
 0.97A 1z11C-1xg2A:
undetectable		 1z11C-1xg2A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1xg2 PECTINESTERASE 1
(Solanum
lycopersicum) 		5 / 10 VAL A 309
ASN A 123
ILE A 122
ILE A 298
LEU A 304
 None
 1.00A 1z11D-1xg2A:
undetectable		 1z11D-1xg2A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 1xg2 PECTINESTERASE 1
(Solanum
lycopersicum) 		3 / 3 THR A 182
PRO A 222
TYR A 259
 None
 0.81A 2dxrA-1xg2A:
undetectable		 2dxrA-1xg2A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1xg2 PECTINESTERASE 1
PECTINESTERASE
INHIBITOR
(Solanum
lycopersicum;
Actinidia
chinensis) 		5 / 12 PHE B  91
TYR B 103
ALA A 159
SER A 138
ALA B 106
 None
 1.15A 2igtB-1xg2B:
undetectable		 2igtB-1xg2B:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1xg2 PECTINESTERASE 1
PECTINESTERASE
INHIBITOR
(Solanum
lycopersicum;
Actinidia
chinensis) 		5 / 12 PHE B  91
TYR B 103
ALA A 159
SER A 138
ALA B 106
 None
 1.15A 2igtC-1xg2B:
undetectable		 2igtC-1xg2B:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 1xg2 PECTINESTERASE 1
(Solanum
lycopersicum) 		4 / 6 ASP A 145
TYR A 147
PHE A 163
LEU A 168
 None
 1.06A 2w98A-1xg2A:
undetectable
2w98B-1xg2A:
undetectable		 2w98A-1xg2A:
21.83
2w98B-1xg2A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 1xg2 PECTINESTERASE 1
(Solanum
lycopersicum) 		5 / 12 LEU A 168
ALA A 136
ALA A 112
GLY A 150
ILE A 197
 None
 1.08A 3c6gA-1xg2A:
undetectable		 3c6gA-1xg2A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 1xg2 PECTINESTERASE 1
(Solanum
lycopersicum) 		4 / 7 LYS A 107
ALA A 103
LEU A  71
THR A 102
 None
 0.92A 3cfqA-1xg2A:
undetectable
3cfqB-1xg2A:
undetectable		 3cfqA-1xg2A:
15.67
3cfqB-1xg2A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 1xg2 PECTINESTERASE 1
(Solanum
lycopersicum) 		4 / 7 LYS A 107
ALA A 103
LEU A  71
THR A 102
 None
 0.97A 3d2tA-1xg2A:
undetectable		 3d2tA-1xg2A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 1xg2 PECTINESTERASE 1
(Solanum
lycopersicum) 		4 / 6 LYS A 107
ALA A 103
LEU A  71
THR A 102
 None
 1.00A 3d2tB-1xg2A:
undetectable		 3d2tB-1xg2A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 1xg2 PECTINESTERASE
INHIBITOR
(Actinidia
chinensis) 		5 / 11 CYH B 139
LEU B 143
LEU B  85
ALA B 104
ALA B 111
 None
 1.29A 3e22D-1xg2B:
undetectable		 3e22D-1xg2B:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1xg2 PECTINESTERASE 1
(Solanum
lycopersicum) 		4 / 8 GLY A 157
ILE A 155
VAL A 161
GLN A 141
 None
 0.75A 3fi0B-1xg2A:
undetectable		 3fi0B-1xg2A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1xg2 PECTINESTERASE 1
PECTINESTERASE
INHIBITOR
(Solanum
lycopersicum;
Actinidia
chinensis) 		4 / 6 TYR A 135
GLY B 112
GLU B 136
GLU A 225
 None
 1.05A 3fpjA-1xg2A:
undetectable		 3fpjA-1xg2A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 1xg2 PECTINESTERASE 1
(Solanum
lycopersicum) 		4 / 7 LEU A 257
SER A 227
THR A 229
VAL A 231
 None
 1.02A 3ozkB-1xg2A:
undetectable		 3ozkB-1xg2A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 1xg2 PECTINESTERASE 1
(Solanum
lycopersicum) 		5 / 11 LEU A 113
THR A  66
THR A  65
GLY A  61
ASP A  96
 None
 1.45A 3sfuC-1xg2A:
undetectable		 3sfuC-1xg2A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 1xg2 PECTINESTERASE 1
(Solanum
lycopersicum) 		5 / 9 LEU A  18
VAL A   7
LEU A  55
ILE A  35
PHE A  92
 None
 1.15A 3tbgD-1xg2A:
undetectable		 3tbgD-1xg2A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 1xg2 PECTINESTERASE 1
(Solanum
lycopersicum) 		4 / 6 LYS A 107
ALA A 103
LEU A  71
THR A 102
 None
 1.04A 4i89A-1xg2A:
undetectable		 4i89A-1xg2A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 1xg2 PECTINESTERASE 1
(Solanum
lycopersicum) 		4 / 7 LYS A 107
ALA A 103
LEU A  71
THR A 102
 None
 1.03A 4iklA-1xg2A:
undetectable
4iklB-1xg2A:
undetectable		 4iklA-1xg2A:
17.24
4iklB-1xg2A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 1xg2 PECTINESTERASE 1
(Solanum
lycopersicum) 		5 / 12 LEU A  94
ILE A  57
LEU A  55
ILE A  35
VAL A  46
 None
 1.07A 4y0rA-1xg2A:
undetectable		 4y0rA-1xg2A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 1xg2 PECTINESTERASE 1
(Solanum
lycopersicum) 		5 / 12 VAL A  46
LEU A  85
ILE A  57
ILE A  35
VAL A   7
 None
 1.02A 4y0rA-1xg2A:
undetectable		 4y0rA-1xg2A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 1xg2 PECTINESTERASE 1
(Solanum
lycopersicum) 		5 / 12 VAL A   7
LEU A  55
ILE A  57
ILE A  67
VAL A  46
 None
 0.89A 4y0sA-1xg2A:
undetectable		 4y0sA-1xg2A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 1xg2 PECTINESTERASE 1
(Solanum
lycopersicum) 		4 / 6 LYS A 107
ALA A 103
LEU A  71
THR A 102
 None
 1.04A 5bojA-1xg2A:
undetectable		 5bojA-1xg2A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1xg2 PECTINESTERASE 1
PECTINESTERASE
INHIBITOR
(Actinidia
chinensis;
Solanum
lycopersicum) 		4 / 7 ALA A 136
ASP B 116
GLY B 110
GLU B 136
 None
 1.01A 5btdA-1xg2A:
undetectable
5btdB-1xg2A:
undetectable
5btdC-1xg2A:
undetectable		 5btdA-1xg2A:
21.27
5btdB-1xg2A:
24.11
5btdC-1xg2A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1xg2 PECTINESTERASE 1
PECTINESTERASE
INHIBITOR
(Actinidia
chinensis;
Solanum
lycopersicum) 		4 / 7 ALA A 136
ASP B 116
GLY B 110
GLU B 136
 None
 1.00A 5btdA-1xg2A:
undetectable
5btdC-1xg2A:
undetectable
5btdD-1xg2A:
undetectable		 5btdA-1xg2A:
21.27
5btdC-1xg2A:
21.27
5btdD-1xg2A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 1xg2 PECTINESTERASE 1
(Solanum
lycopersicum) 		4 / 6 LYS A 107
ALA A 103
LEU A  71
THR A 102
 None
 0.98A 5l4iA-1xg2A:
undetectable		 5l4iA-1xg2A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 1xg2 PECTINESTERASE 1
(Solanum
lycopersicum) 		5 / 10 VAL A 231
ILE A 197
LEU A 168
PHE A 163
GLY A 220
 None
 1.19A 5mxbA-1xg2A:
undetectable		 5mxbA-1xg2A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1xg2 PECTINESTERASE
INHIBITOR
(Actinidia
chinensis) 		5 / 9 LEU B 138
ILE B  43
GLY B  37
LEU B  17
ALA B  21
 None
 0.78A 5o96A-1xg2B:
undetectable
5o96B-1xg2B:
undetectable		 5o96A-1xg2B:
19.84
5o96B-1xg2B:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 1xg2 PECTINESTERASE
INHIBITOR
(Actinidia
chinensis) 		5 / 12 ARG B  13
LEU B  17
ILE B  43
ALA B 104
GLY B 110
 None
 1.11A 5veuA-1xg2B:
undetectable		 5veuA-1xg2B:
15.03