SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xg5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 1xg5 ARPG836
(Homo
sapiens) 		5 / 12 ILE A  95
GLY A  99
VAL A 236
ALA A  25
LEU A  31
 None
NAP  A1301 (-3.6A)
None
None
None
 0.91A 1vptA-1xg5A:
5.4		 1vptA-1xg5A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1xg5 ARPG836
(Homo
sapiens) 		5 / 12 GLY A  18
ARG A  43
ASP A  70
SER A  72
ALA A  98
 NAP  A1301 (-3.5A)
NAP  A1301 (-3.8A)
NAP  A1301 (-3.8A)
NAP  A1301 ( 4.3A)
NAP  A1301 (-3.6A)
 0.94A 2br4C-1xg5A:
6.3		 2br4C-1xg5A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1xg5 ARPG836
(Homo
sapiens) 		5 / 12 ILE A 146
ALA A 193
ALA A 233
VAL A 232
VAL A  16
 None
 0.91A 2yvlA-1xg5A:
6.8		 2yvlA-1xg5A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 1xg5 ARPG836
(Homo
sapiens) 		5 / 12 ILE A 146
ALA A 193
ALA A 233
VAL A 232
VAL A  16
 None
 0.88A 2yvlB-1xg5A:
6.8		 2yvlB-1xg5A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 1xg5 ARPG836
(Homo
sapiens) 		5 / 12 ILE A 146
ALA A 193
ALA A 233
VAL A 232
VAL A  16
 None
 0.89A 2yvlC-1xg5A:
7.0		 2yvlC-1xg5A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 1xg5 ARPG836
(Homo
sapiens) 		5 / 12 ILE A 146
ALA A 193
ALA A 233
VAL A 232
VAL A  16
 None
 0.81A 2yvlD-1xg5A:
6.8		 2yvlD-1xg5A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1xg5 ARPG836
(Homo
sapiens) 		5 / 12 GLY A  18
GLY A  21
ALA A  26
ASP A  70
VAL A 120
 NAP  A1301 (-3.5A)
NAP  A1301 (-4.3A)
None
NAP  A1301 (-3.8A)
None
 0.79A 3dmfA-1xg5A:
4.4		 3dmfA-1xg5A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 1xg5 ARPG836
(Homo
sapiens) 		4 / 6 ALA A  28
ILE A  48
LEU A  64
ALA A  14
 None
 0.75A 3r9sA-1xg5A:
undetectable		 3r9sA-1xg5A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1xg5 ARPG836
(Homo
sapiens) 		5 / 12 GLY A  24
GLY A  40
ALA A  28
ARG A  29
ALA A  52
 None
 0.89A 3sugA-1xg5A:
undetectable		 3sugA-1xg5A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1xg5 ARPG836
(Homo
sapiens) 		5 / 12 GLY A  24
ALA A  25
SER A  20
ILE A 196
SER A 197
 None
None
NAP  A1301 (-2.7A)
None
None
 1.27A 4rtpA-1xg5A:
5.1		 4rtpA-1xg5A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 1xg5 ARPG836
(Homo
sapiens) 		5 / 11 THR A 203
PHE A 205
ALA A 101
THR A 163
LEU A 158
 NAP  A1301 (-2.6A)
ACY  A1401 ( 3.9A)
None
None
None
 1.44A 6efnA-1xg5A:
2.0		 6efnA-1xg5A:
22.28