SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xg8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HWK_A_117A2_1 (HMG-COA REDUCTASE)	1xg8	HYPOTHETICAL PROTEIN SA0798 (Staphylococcus aureus)	4 / 8	SER A 19 VAL A 3 ASP A 45 LYS A 48	None	1.26A	1hwkA-1xg8A: undetectable	1hwkA-1xg8A: 14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AOU_A_CQAA403_0 (HISTAMINE N-METHYLTRANSFERASE)	1xg8	HYPOTHETICAL PROTEIN SA0798 (Staphylococcus aureus)	4 / 8	ASP A 21 GLY A 5 ASP A 83 THR A 75	None	0.97A	2aouA-1xg8A: undetectable	2aouA-1xg8A: 17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YA7_A_ZMRA1776_2 (NEURAMINIDASE A)	1xg8	HYPOTHETICAL PROTEIN SA0798 (Staphylococcus aureus)	4 / 6	ASP A 45 ILE A 44 LEU A 53 GLU A 65	None	0.85A	2ya7A-1xg8A: undetectable	2ya7A-1xg8A: 12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YA7_B_ZMRB1776_2 (NEURAMINIDASE A)	1xg8	HYPOTHETICAL PROTEIN SA0798 (Staphylococcus aureus)	4 / 6	ASP A 45 ILE A 44 LEU A 53 GLU A 65	None	0.83A	2ya7B-1xg8A: undetectable	2ya7B-1xg8A: 12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YA7_D_ZMRD1776_2 (NEURAMINIDASE A)	1xg8	HYPOTHETICAL PROTEIN SA0798 (Staphylococcus aureus)	4 / 6	ASP A 45 ILE A 44 LEU A 53 GLU A 65	None	0.85A	2ya7D-1xg8A: undetectable	2ya7D-1xg8A: 12.74

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1HWK_A_117A2_1","HMG-COA REDUCTASE","1xg8","HYPOTHETICAL PROTEIN SA0798","Staphylococcus aureus",4,"SER A  19;VAL A   3;ASP A  45;LYS A  48","None","1.26A","1hwkA-1xg8A:undetectable","1hwkA-1xg8A:14.32"],["2AOU_A_CQAA403_0","HISTAMINE N-METHYLTRANSFERASE","1xg8","HYPOTHETICAL PROTEIN SA0798","Staphylococcus aureus",4,"ASP A  21;GLY A   5;ASP A  83;THR A  75","None","0.97A","2aouA-1xg8A:undetectable","2aouA-1xg8A:17.59"],["2YA7_A_ZMRA1776_2","NEURAMINIDASE A","1xg8","HYPOTHETICAL PROTEIN SA0798","Staphylococcus aureus",4,"ASP A  45;ILE A  44;LEU A  53;GLU A  65","None","0.85A","2ya7A-1xg8A:undetectable","2ya7A-1xg8A:12.74"],["2YA7_B_ZMRB1776_2","NEURAMINIDASE A","1xg8","HYPOTHETICAL PROTEIN SA0798","Staphylococcus aureus",4,"ASP A  45;ILE A  44;LEU A  53;GLU A  65","None","0.83A","2ya7B-1xg8A:undetectable","2ya7B-1xg8A:12.74"],["2YA7_D_ZMRD1776_2","NEURAMINIDASE A","1xg8","HYPOTHETICAL PROTEIN SA0798","Staphylococcus aureus",4,"ASP A  45;ILE A  44;LEU A  53;GLU A  65","None","0.85A","2ya7D-1xg8A:undetectable","2ya7D-1xg8A:12.74"]]