SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xgy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 1xgy K42-41L FAB HEAVY
CHAIN
K42-41L FAB LIGHT
CHAIN
(Mus
musculus) 		7 / 12 TYR L  36
LEU L  96
PHE L  98
ASN H  35
VAL H  37
ALA H  93
TRP H 103
 None
 0.53A 1h8sA-1xgyL:
19.8		 1h8sA-1xgyL:
36.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_A_ACTA4901_0
(PYRANOSE OXIDASE)		 1xgy K42-41L FAB HEAVY
CHAIN
K42-41L FAB LIGHT
CHAIN
(Mus
musculus;
Mus
musculus) 		4 / 6 THR H 137
PHE H 166
HIS H 164
ASN L 137
 None
 1.49A 1tt0A-1xgyH:
0.0		 1tt0A-1xgyH:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_B_ACTB3901_0
(PYRANOSE OXIDASE)		 1xgy K42-41L FAB HEAVY
CHAIN
K42-41L FAB LIGHT
CHAIN
(Mus
musculus;
Mus
musculus) 		4 / 6 THR H 137
PHE H 166
HIS H 164
ASN L 137
 None
 1.50A 1tt0B-1xgyH:
0.0		 1tt0B-1xgyH:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_C_ACTC6901_0
(PYRANOSE OXIDASE)		 1xgy K42-41L FAB HEAVY
CHAIN
K42-41L FAB LIGHT
CHAIN
(Mus
musculus;
Mus
musculus) 		4 / 6 THR H 137
PHE H 166
HIS H 164
ASN L 137
 None
 1.48A 1tt0C-1xgyH:
undetectable		 1tt0C-1xgyH:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_D_ACTD5901_0
(PYRANOSE OXIDASE)		 1xgy K42-41L FAB HEAVY
CHAIN
K42-41L FAB LIGHT
CHAIN
(Mus
musculus;
Mus
musculus) 		4 / 6 THR H 137
PHE H 166
HIS H 164
ASN L 137
 None
 1.48A 1tt0D-1xgyH:
undetectable		 1tt0D-1xgyH:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 1xgy K42-41L FAB HEAVY
CHAIN
(Mus
musculus) 		4 / 8 TYR H  27
THR H  94
LEU H   4
VAL H  71
 None
 1.12A 1uyuA-1xgyH:
undetectable		 1uyuA-1xgyH:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 1xgy K42-41L FAB HEAVY
CHAIN
(Mus
musculus) 		4 / 8 TYR H  27
THR H  94
LEU H   4
VAL H  71
 None
 1.17A 1uyuB-1xgyH:
undetectable		 1uyuB-1xgyH:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 1xgy K42-41L FAB HEAVY
CHAIN
(Mus
musculus) 		4 / 6 TYR H  27
THR H  94
LEU H   4
VAL H  71
 None
 1.08A 2feuA-1xgyH:
undetectable		 2feuA-1xgyH:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1xgy K42-41L FAB HEAVY
CHAIN
(Mus
musculus) 		3 / 3 VAL H 193
VAL H 163
SER H 161
 None
 0.64A 3n8xB-1xgyH:
undetectable		 3n8xB-1xgyH:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 1xgy K42-41L FAB HEAVY
CHAIN
(Mus
musculus) 		5 / 12 VAL H 163
VAL H 181
SER H 179
ASN H 196
ASN H 155
 None
 1.42A 3nyaA-1xgyH:
undetectable		 3nyaA-1xgyH:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 1xgy K42-41L FAB LIGHT
CHAIN
(Mus
musculus) 		4 / 6 ARG L  39
PHE L  62
PRO L  59
LEU L  47
 None
 1.43A 3tgvB-1xgyL:
undetectable		 3tgvB-1xgyL:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1xgy K42-41L FAB LIGHT
CHAIN
(Mus
musculus) 		4 / 6 LEU L  27
LYS L  27
LEU L  92
GLU L  93
 None
 0.99A 4f3tA-1xgyL:
undetectable		 4f3tA-1xgyL:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1xgy K42-41L FAB HEAVY
CHAIN
(Mus
musculus) 		4 / 8 TYR H  27
THR H  94
LEU H   4
VAL H  71
 None
 1.10A 4l4dA-1xgyH:
undetectable		 4l4dA-1xgyH:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1xgy K42-41L FAB HEAVY
CHAIN
(Mus
musculus) 		4 / 8 TYR H  27
THR H  94
LEU H   4
VAL H  71
 None
 1.11A 4l4fA-1xgyH:
0.0		 4l4fA-1xgyH:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1xgy K42-41L FAB HEAVY
CHAIN
(Mus
musculus) 		4 / 5 VAL H  18
ILE H  20
VAL H 109
THR H 107
 None
 0.68A 4xdtA-1xgyH:
undetectable		 4xdtA-1xgyH:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1xgy K42-41L FAB LIGHT
CHAIN
(Mus
musculus) 		3 / 3 MET L   4
GLN L   6
ARG L  24
 None
 1.11A 5ewzB-1xgyL:
undetectable		 5ewzB-1xgyL:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1xgy K42-41L FAB LIGHT
CHAIN
(Mus
musculus) 		4 / 6 ILE L  75
VAL L  13
VAL L  78
SER L  10
 None
 0.94A 5jwaH-1xgyL:
undetectable		 5jwaH-1xgyL:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1xgy K42-41L FAB LIGHT
CHAIN
(Mus
musculus) 		3 / 3 MET L   4
GLN L   6
ARG L  24
 None
 1.08A 5m35B-1xgyL:
undetectable		 5m35B-1xgyL:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1xgy K42-41L FAB LIGHT
CHAIN
(Mus
musculus) 		3 / 3 MET L   4
GLN L   6
ARG L  24
 None
 1.06A 5m36A-1xgyL:
undetectable		 5m36A-1xgyL:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1xgy K42-41L FAB LIGHT
CHAIN
(Mus
musculus) 		4 / 5 ILE L 117
PHE L 209
ARG L 155
THR L 180
 None
 1.30A 5z84N-1xgyL:
undetectable
5z84W-1xgyL:
undetectable		 5z84N-1xgyL:
16.60
5z84W-1xgyL:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1xgy K42-41L FAB LIGHT
CHAIN
(Mus
musculus) 		3 / 3 MET L   4
GLN L   6
ARG L  24
 None
 1.07A 6fn9A-1xgyL:
undetectable		 6fn9A-1xgyL:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1xgy K42-41L FAB LIGHT
CHAIN
(Mus
musculus) 		3 / 3 MET L   4
GLN L   6
ARG L  24
 None
 1.07A 6fnaB-1xgyL:
undetectable		 6fnaB-1xgyL:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1xgy K42-41L FAB LIGHT
CHAIN
(Mus
musculus) 		3 / 3 MET L   4
GLN L   6
ARG L  24
 None
 1.07A 6fnbA-1xgyL:
undetectable		 6fnbA-1xgyL:
19.59