SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xhb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1
(Mus
musculus) 		5 / 7 GLY A 217
ASP A 239
SER A 340
HIS A 341
ALA A 250
 None
 1.30A 1gxsA-1xhbA:
undetectable
1gxsB-1xhbA:
undetectable		 1gxsA-1xhbA:
19.96
1gxsB-1xhbA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_C_BEZC602_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1
(Mus
musculus) 		5 / 9 GLY A 217
ASP A 239
SER A 340
HIS A 341
ALA A 250
 None
 1.28A 1gxsC-1xhbA:
0.0
1gxsD-1xhbA:
0.0		 1gxsC-1xhbA:
19.96
1gxsD-1xhbA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1
(Mus
musculus) 		4 / 5 SER A 324
THR A 290
PHE A 265
GLY A 293
 None
 1.26A 1icrA-1xhbA:
undetectable
1icrB-1xhbA:
undetectable		 1icrA-1xhbA:
19.49
1icrB-1xhbA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1
(Mus
musculus) 		4 / 5 GLY A 293
SER A 324
THR A 290
PHE A 265
 None
 1.27A 1icrA-1xhbA:
undetectable
1icrB-1xhbA:
undetectable		 1icrA-1xhbA:
19.49
1icrB-1xhbA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1
(Mus
musculus) 		4 / 5 GLY A 293
SER A 324
THR A 290
PHE A 265
 None
 1.15A 1icuC-1xhbA:
undetectable
1icuD-1xhbA:
undetectable		 1icuC-1xhbA:
19.49
1icuD-1xhbA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1
(Mus
musculus) 		4 / 5 GLY A 293
SER A 324
THR A 290
PHE A 265
 None
 1.17A 1icvA-1xhbA:
undetectable
1icvB-1xhbA:
undetectable		 1icvA-1xhbA:
19.49
1icvB-1xhbA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1
(Mus
musculus) 		4 / 5 SER A 324
THR A 290
PHE A 265
GLY A 293
 None
 1.24A 1icvC-1xhbA:
undetectable
1icvD-1xhbA:
undetectable		 1icvC-1xhbA:
19.49
1icvD-1xhbA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1
(Mus
musculus) 		4 / 5 GLY A 293
SER A 324
THR A 290
PHE A 265
 None
 1.20A 1icvC-1xhbA:
undetectable
1icvD-1xhbA:
undetectable		 1icvC-1xhbA:
19.49
1icvD-1xhbA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1
(Mus
musculus) 		4 / 6 TYR A 419
VAL A 286
ILE A 336
LEU A 321
 None
 1.24A 1j96A-1xhbA:
undetectable		 1j96A-1xhbA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		 1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1
(Mus
musculus) 		4 / 5 CYH A 235
PRO A 285
THR A 118
THR A 206
 None
 1.25A 1ymxB-1xhbA:
undetectable		 1ymxB-1xhbA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1
(Mus
musculus) 		5 / 12 GLY A 293
ALA A 292
VAL A 234
VAL A 342
ILE A 238
 None
 1.07A 3cyxA-1xhbA:
undetectable		 3cyxA-1xhbA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1
(Mus
musculus) 		5 / 8 LEU A 222
VAL A 120
LEU A 208
ILE A 148
VAL A 139
 None
 1.13A 3kp6A-1xhbA:
undetectable
3kp6B-1xhbA:
undetectable		 3kp6A-1xhbA:
16.46
3kp6B-1xhbA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1
(Mus
musculus) 		5 / 9 LEU A 208
THR A 118
LEU A 223
LEU A 219
SER A 143
 None
 1.35A 3q1eB-1xhbA:
0.0
3q1eD-1xhbA:
0.0		 3q1eB-1xhbA:
14.22
3q1eD-1xhbA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1
(Mus
musculus) 		3 / 3 HIS A 125
ARG A 186
GLU A 159
 None
 1.07A 3qf1A-1xhbA:
undetectable		 3qf1A-1xhbA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1
(Mus
musculus) 		4 / 4 VAL A 467
PHE A 380
PHE A 381
VAL A 388
 None
 1.42A 3rv5C-1xhbA:
0.0
3rv5D-1xhbA:
0.0		 3rv5C-1xhbA:
11.04
3rv5D-1xhbA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1
(Mus
musculus) 		4 / 4 ASP A 301
ASP A 299
GLY A 202
THR A 206
 None
 1.21A 3tl9B-1xhbA:
undetectable		 3tl9B-1xhbA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1
(Mus
musculus) 		5 / 12 LEU A 443
LEU A 550
ILE A 476
TYR A 470
PHE A 429
 None
None
None
None
NAG  A 700 (-4.0A)
 1.32A 4a79B-1xhbA:
undetectable		 4a79B-1xhbA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1
(Mus
musculus) 		5 / 11 ILE A 434
GLN A 441
LEU A 443
VAL A 454
LEU A 524
 None
 0.95A 4g1bB-1xhbA:
undetectable		 4g1bB-1xhbA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1
(Mus
musculus) 		5 / 12 ILE A 434
GLN A 441
LEU A 443
VAL A 454
LEU A 524
 None
 0.95A 4g1bD-1xhbA:
2.5		 4g1bD-1xhbA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1
(Mus
musculus) 		3 / 3 LYS A 364
TYR A 393
ARG A 368
 None
 1.14A 4gc9A-1xhbA:
undetectable		 4gc9A-1xhbA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1
(Mus
musculus) 		4 / 8 PRO A 535
VAL A 454
ASN A 445
ILE A 434
 None
 1.11A 4iilA-1xhbA:
undetectable		 4iilA-1xhbA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1
(Mus
musculus) 		5 / 12 VAL A 372
GLY A 307
SER A 398
SER A 397
GLY A 401
 None
None
CA  A 602 ( 3.7A)
None
None
 1.18A 4mmdB-1xhbA:
undetectable		 4mmdB-1xhbA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_1
(PROTEASE)		 1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1
(Mus
musculus) 		5 / 12 GLY A 217
ILE A 237
PRO A 285
ILE A 226
THR A 206
 None
 1.04A 4q5mA-1xhbA:
undetectable		 4q5mA-1xhbA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1
(Mus
musculus) 		5 / 11 ALA A 311
VAL A 372
GLY A 307
SER A 398
GLY A 401
 None
None
None
CA  A 602 ( 3.7A)
None
 1.08A 4xp4A-1xhbA:
undetectable		 4xp4A-1xhbA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1
(Mus
musculus) 		4 / 6 GLU A 274
ARG A 287
ARG A 273
ARG A 277
 None
 1.21A 5l6eA-1xhbA:
undetectable
5l6eB-1xhbA:
undetectable		 5l6eA-1xhbA:
18.14
5l6eB-1xhbA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1
(Mus
musculus) 		4 / 6 THR A 206
ARG A 193
LEU A 208
ASP A 209
 None
None
None
MN  A 600 (-3.2A)
 1.19A 5tdzA-1xhbA:
undetectable		 5tdzA-1xhbA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1
(Mus
musculus) 		4 / 7 ARG A 160
PHE A 124
ARG A 186
ASP A 156
 None
 1.31A 5uxcA-1xhbA:
undetectable		 5uxcA-1xhbA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1
(Mus
musculus) 		3 / 3 LEU A 483
ASN A 436
LEU A 550
 None
 0.66A 6exiA-1xhbA:
undetectable		 6exiA-1xhbA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1
(Mus
musculus) 		4 / 6 ILE A 537
LEU A 488
VAL A 485
SER A 520
 None
 0.99A 6f6jA-1xhbA:
undetectable		 6f6jA-1xhbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1
(Mus
musculus) 		5 / 12 VAL A 391
VAL A 388
ASP A 395
ASN A 365
TYR A 382
 None
 1.25A 6iblA-1xhbA:
undetectable		 6iblA-1xhbA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1
(Mus
musculus) 		5 / 12 VAL A 391
VAL A 388
ASP A 395
ASN A 365
VAL A 372
 None
 1.41A 6iblA-1xhbA:
undetectable		 6iblA-1xhbA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1
(Mus
musculus) 		5 / 12 VAL A 391
VAL A 388
ASP A 395
ASN A 365
TYR A 382
 None
 1.19A 6iblB-1xhbA:
undetectable		 6iblB-1xhbA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1
(Mus
musculus) 		5 / 12 VAL A 391
VAL A 388
ASP A 395
ASN A 365
VAL A 372
 None
 1.36A 6iblB-1xhbA:
undetectable		 6iblB-1xhbA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_A_FK5A201_0
(PEPTIDYLPROLYL
ISOMERASE)		 1xhb POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 1
(Mus
musculus) 		5 / 12 ASP A 375
ARG A 403
ILE A 424
TYR A 393
ILE A 396
 None
 0.95A 6mkeA-1xhbA:
undetectable
6mkeD-1xhbA:
undetectable		 6mkeA-1xhbA:
11.55
6mkeD-1xhbA:
11.55