SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xhc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 1xhc NADH OXIDASE
/NITRITE REDUCTASE
(Pyrococcus
furiosus) 		5 / 11 MET A  40
GLY A 305
ILE A  45
GLU A 156
ALA A  46
 None
 1.11A 2yy8A-1xhcA:
4.1
2yy8B-1xhcA:
3.7		 2yy8A-1xhcA:
20.33
2yy8B-1xhcA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 1xhc NADH OXIDASE
/NITRITE REDUCTASE
(Pyrococcus
furiosus) 		5 / 11 ALA A 272
ARG A 120
PHE A 145
ILE A 224
GLY A 270
 FAD  A 360 (-3.8A)
FAD  A 360 (-3.9A)
FAD  A 360 (-4.4A)
None
FAD  A 360 (-4.3A)
 1.43A 3bpxA-1xhcA:
undetectable
3bpxB-1xhcA:
undetectable		 3bpxA-1xhcA:
19.62
3bpxB-1xhcA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 1xhc NADH OXIDASE
/NITRITE REDUCTASE
(Pyrococcus
furiosus) 		5 / 12 VAL A  85
LEU A 230
SER A 234
VAL A   6
THR A 250
 None
FAD  A 360 ( 4.3A)
None
None
None
 1.25A 3frqA-1xhcA:
undetectable		 3frqA-1xhcA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 1xhc NADH OXIDASE
/NITRITE REDUCTASE
(Pyrococcus
furiosus) 		4 / 5 ASP A 174
GLU A 318
GLY A 319
GLU A 176
 None
 1.11A 3w9tA-1xhcA:
undetectable		 3w9tA-1xhcA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 1xhc NADH OXIDASE
/NITRITE REDUCTASE
(Pyrococcus
furiosus) 		4 / 6 ASP A 174
GLU A 318
GLY A 319
GLU A 176
 None
 1.10A 3w9tB-1xhcA:
undetectable		 3w9tB-1xhcA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 1xhc NADH OXIDASE
/NITRITE REDUCTASE
(Pyrococcus
furiosus) 		4 / 5 ASP A 174
GLU A 318
GLY A 319
GLU A 176
 None
 1.11A 3w9tC-1xhcA:
undetectable		 3w9tC-1xhcA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 1xhc NADH OXIDASE
/NITRITE REDUCTASE
(Pyrococcus
furiosus) 		4 / 5 ASP A 174
GLU A 318
GLY A 319
GLU A 176
 None
 1.11A 3w9tD-1xhcA:
undetectable		 3w9tD-1xhcA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 1xhc NADH OXIDASE
/NITRITE REDUCTASE
(Pyrococcus
furiosus) 		4 / 6 ASP A 174
GLU A 318
GLY A 319
GLU A 176
 None
 1.11A 3w9tE-1xhcA:
undetectable		 3w9tE-1xhcA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 1xhc NADH OXIDASE
/NITRITE REDUCTASE
(Pyrococcus
furiosus) 		4 / 6 ASP A 174
GLU A 318
GLY A 319
GLU A 176
 None
 1.09A 3w9tF-1xhcA:
undetectable		 3w9tF-1xhcA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 1xhc NADH OXIDASE
/NITRITE REDUCTASE
(Pyrococcus
furiosus) 		4 / 5 ASP A 174
GLU A 318
GLY A 319
GLU A 176
 None
 1.11A 3w9tG-1xhcA:
undetectable		 3w9tG-1xhcA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 1xhc NADH OXIDASE
/NITRITE REDUCTASE
(Pyrococcus
furiosus) 		4 / 7 LEU A 150
ALA A 138
VAL A 206
ILE A 140
 None
 0.93A 3wsjB-1xhcA:
undetectable		 3wsjB-1xhcA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1xhc NADH OXIDASE
/NITRITE REDUCTASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 307
PHE A 304
THR A 300
ILE A 311
LEU A 171
 None
None
FAD  A 360 ( 4.7A)
None
None
 1.15A 4x5fA-1xhcA:
2.0		 4x5fA-1xhcA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1xhc NADH OXIDASE
/NITRITE REDUCTASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 307
PHE A 304
THR A 300
ILE A 311
LEU A 171
 None
None
FAD  A 360 ( 4.7A)
None
None
 1.08A 4x5hA-1xhcA:
undetectable		 4x5hA-1xhcA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1xhc NADH OXIDASE
/NITRITE REDUCTASE
(Pyrococcus
furiosus) 		4 / 7 ARG A 249
ASP A 245
ILE A 244
TYR A 264
 None
 1.28A 5a06B-1xhcA:
undetectable		 5a06B-1xhcA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 1xhc NADH OXIDASE
/NITRITE REDUCTASE
(Pyrococcus
furiosus) 		3 / 3 TRP A  61
ILE A  67
SER A  20
 None
 0.86A 5gqbA-1xhcA:
undetectable		 5gqbA-1xhcA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 1xhc NADH OXIDASE
/NITRITE REDUCTASE
(Pyrococcus
furiosus) 		6 / 11 VAL A   6
GLY A   7
LYS A  30
ALA A  75
LEU A 230
ASN A 227
 None
FAD  A 360 (-3.2A)
FAD  A 360 (-4.7A)
FAD  A 360 (-3.6A)
FAD  A 360 ( 4.3A)
None
 1.04A 5x6yA-1xhcA:
2.9		 5x6yA-1xhcA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 1xhc NADH OXIDASE
/NITRITE REDUCTASE
(Pyrococcus
furiosus) 		5 / 10 VAL A   6
GLY A   7
ALA A  75
LEU A 230
ASN A 227
 None
FAD  A 360 (-3.2A)
FAD  A 360 (-3.6A)
FAD  A 360 ( 4.3A)
None
 0.68A 5x6yB-1xhcA:
3.1		 5x6yB-1xhcA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 1xhc NADH OXIDASE
/NITRITE REDUCTASE
(Pyrococcus
furiosus) 		5 / 10 VAL A   6
GLY A   7
LYS A  30
ALA A  75
ASN A 227
 None
FAD  A 360 (-3.2A)
FAD  A 360 (-4.7A)
FAD  A 360 (-3.6A)
None
 0.80A 5x6yB-1xhcA:
3.1		 5x6yB-1xhcA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 1xhc NADH OXIDASE
/NITRITE REDUCTASE
(Pyrococcus
furiosus) 		5 / 11 VAL A   6
GLY A   7
ALA A  75
LEU A 230
ASN A 227
 None
FAD  A 360 (-3.2A)
FAD  A 360 (-3.6A)
FAD  A 360 ( 4.3A)
None
 1.02A 5x6yC-1xhcA:
undetectable		 5x6yC-1xhcA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 1xhc NADH OXIDASE
/NITRITE REDUCTASE
(Pyrococcus
furiosus) 		5 / 11 VAL A   6
GLY A   7
LYS A  30
ALA A  75
ASN A 227
 None
FAD  A 360 (-3.2A)
FAD  A 360 (-4.7A)
FAD  A 360 (-3.6A)
None
 1.05A 5x6yC-1xhcA:
undetectable		 5x6yC-1xhcA:
18.79