SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xhk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 1xhk PUTATIVE PROTEASE LA
HOMOLOG
(Methanocaldococc
us
jannaschii) 		5 / 11 ALA A 610
ILE A 607
GLY A 576
TYR A 543
ALA A 466
 None
 1.13A 1b02A-1xhkA:
undetectable		 1b02A-1xhkA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 1xhk PUTATIVE PROTEASE LA
HOMOLOG
(Methanocaldococc
us
jannaschii) 		4 / 5 LYS A 514
GLU A 518
ALA A 510
LEU A 507
 None
 1.10A 1eta1-1xhkA:
undetectable		 1eta1-1xhkA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 1xhk PUTATIVE PROTEASE LA
HOMOLOG
(Methanocaldococc
us
jannaschii) 		4 / 5 LYS A 514
GLU A 518
ALA A 510
LEU A 507
 None
 1.04A 1eta2-1xhkA:
undetectable		 1eta2-1xhkA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 1xhk PUTATIVE PROTEASE LA
HOMOLOG
(Methanocaldococc
us
jannaschii) 		4 / 6 LYS A 514
GLU A 518
ALA A 510
LEU A 507
 None
 1.12A 1etb1-1xhkA:
undetectable		 1etb1-1xhkA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 1xhk PUTATIVE PROTEASE LA
HOMOLOG
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A 546
SER A 550
ASN A 611
GLY A 548
ASP A 547
 None
 1.35A 1ho5A-1xhkA:
undetectable		 1ho5A-1xhkA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 1xhk PUTATIVE PROTEASE LA
HOMOLOG
(Methanocaldococc
us
jannaschii) 		5 / 8 ALA A 466
ILE A 587
GLY A 588
GLY A 589
ALA A 573
 None
 1.24A 1sguA-1xhkA:
undetectable		 1sguA-1xhkA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 1xhk PUTATIVE PROTEASE LA
HOMOLOG
(Methanocaldococc
us
jannaschii) 		5 / 8 ALA A 466
ILE A 587
GLY A 588
GLY A 589
ALA A 597
 None
 1.10A 1sguA-1xhkA:
undetectable		 1sguA-1xhkA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 1xhk PUTATIVE PROTEASE LA
HOMOLOG
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A 629
LEU A 563
SER A 512
LEU A 515
VAL A 516
 None
 0.91A 2c12C-1xhkA:
0.0		 2c12C-1xhkA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 1xhk PUTATIVE PROTEASE LA
HOMOLOG
(Methanocaldococc
us
jannaschii) 		4 / 6 LYS A 514
GLU A 518
ALA A 510
LEU A 507
 None
 1.03A 2roxB-1xhkA:
undetectable		 2roxB-1xhkA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 1xhk PUTATIVE PROTEASE LA
HOMOLOG
(Methanocaldococc
us
jannaschii) 		5 / 12 ASP A 565
ILE A 483
VAL A 636
ILE A 632
ILE A 559
 None
 1.11A 3ohtA-1xhkA:
undetectable
3ohtB-1xhkA:
undetectable		 3ohtA-1xhkA:
21.81
3ohtB-1xhkA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1xhk PUTATIVE PROTEASE LA
HOMOLOG
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE A 462
ILE A 606
PHE A 572
LEU A 578
 None
 0.76A 3ua5A-1xhkA:
undetectable		 3ua5A-1xhkA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 1xhk PUTATIVE PROTEASE LA
HOMOLOG
(Methanocaldococc
us
jannaschii) 		5 / 9 VAL A 467
GLY A 548
SER A 550
ALA A 551
LYS A 593
 None
 0.80A 4fwdA-1xhkA:
13.3		 4fwdA-1xhkA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 1xhk PUTATIVE PROTEASE LA
HOMOLOG
(Methanocaldococc
us
jannaschii) 		4 / 7 GLU A 485
ASP A 529
ASN A 531
ILE A 535
 None
 1.08A 4ii8A-1xhkA:
undetectable		 4ii8A-1xhkA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 1xhk PUTATIVE PROTEASE LA
HOMOLOG
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 466
GLY A 548
SER A 550
ALA A 551
LYS A 593
 None
 0.73A 4ypmA-1xhkA:
21.7		 4ypmA-1xhkA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1xhk PUTATIVE PROTEASE LA
HOMOLOG
(Methanocaldococc
us
jannaschii) 		4 / 8 VAL A 467
ALA A 466
GLY A 464
GLY A 576
 None
 0.88A 5e26C-1xhkA:
undetectable
5e26D-1xhkA:
undetectable		 5e26C-1xhkA:
21.10
5e26D-1xhkA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 1xhk PUTATIVE PROTEASE LA
HOMOLOG
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE A 479
ALA A 551
ALA A 573
ILE A 574
 None
 0.70A 5mvmA-1xhkA:
undetectable
5mvmB-1xhkA:
undetectable		 5mvmA-1xhkA:
20.59
5mvmB-1xhkA:
20.59