SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xhn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 1xhn CELLULAR REPRESSOR
OF E1A-STIMULATED
GENES
(Homo
sapiens) 		3 / 3 TYR A 166
GLY A 169
PHE A 167
 None
 0.64A 2m2pB-1xhnA:
undetectable		 2m2pB-1xhnA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 1xhn CELLULAR REPRESSOR
OF E1A-STIMULATED
GENES
(Homo
sapiens) 		5 / 12 VAL A 181
ALA A  20
LEU A  89
LEU A 116
ILE A 114
 None
 0.90A 3gcsA-1xhnA:
undetectable		 3gcsA-1xhnA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 1xhn CELLULAR REPRESSOR
OF E1A-STIMULATED
GENES
(Homo
sapiens) 		4 / 8 ALA A  19
ALA A  23
THR A  27
LEU A 116
 None
 0.98A 3l4dA-1xhnA:
undetectable		 3l4dA-1xhnA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 1xhn CELLULAR REPRESSOR
OF E1A-STIMULATED
GENES
(Homo
sapiens) 		3 / 3 ASP A  57
LEU A  89
VAL A 163
 None
 0.70A 4jecB-1xhnA:
undetectable		 4jecB-1xhnA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 1xhn CELLULAR REPRESSOR
OF E1A-STIMULATED
GENES
(Homo
sapiens) 		4 / 8 MET A  91
LEU A  55
HIS A 139
ILE A 137
 None
 0.97A 4ok1A-1xhnA:
undetectable		 4ok1A-1xhnA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 1xhn CELLULAR REPRESSOR
OF E1A-STIMULATED
GENES
(Homo
sapiens) 		4 / 7 LEU A 156
MET A  91
LEU A  55
ILE A 130
 None
 0.86A 4okwA-1xhnA:
undetectable		 4okwA-1xhnA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 1xhn CELLULAR REPRESSOR
OF E1A-STIMULATED
GENES
(Homo
sapiens) 		4 / 6 ASN A  84
TYR A  86
VAL A 120
THR A 119
 None
 1.09A 6f32B-1xhnA:
undetectable		 6f32B-1xhnA:
15.94