SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xi6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1xi6 EXTRAGENIC
SUPPRESSOR
(Pyrococcus
furiosus) 		4 / 7 LEU A  53
ILE A  13
ALA A 181
ILE A 209
 None
 0.76A 2xkwA-1xi6A:
undetectable		 2xkwA-1xi6A:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1xi6 EXTRAGENIC
SUPPRESSOR
(Pyrococcus
furiosus) 		4 / 7 VAL A  65
VAL A  83
LEU A 103
SER A 102
 None
 0.87A 3hs6B-1xi6A:
undetectable		 3hs6B-1xi6A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 1xi6 EXTRAGENIC
SUPPRESSOR
(Pyrococcus
furiosus) 		5 / 12 ILE A 128
GLY A 127
ALA A 205
ALA A 213
ILE A 115
 None
 1.04A 3jayA-1xi6A:
0.8		 3jayA-1xi6A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 1xi6 EXTRAGENIC
SUPPRESSOR
(Pyrococcus
furiosus) 		5 / 12 ILE A 128
GLY A 127
ALA A 205
ALA A 213
ILE A 115
 None
 0.97A 3jb1A-1xi6A:
undetectable		 3jb1A-1xi6A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1xi6 EXTRAGENIC
SUPPRESSOR
(Pyrococcus
furiosus) 		4 / 8 GLY A 127
GLY A 206
LEU A 180
LEU A 183
 None
 0.65A 4mwzB-1xi6A:
undetectable		 4mwzB-1xi6A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1xi6 EXTRAGENIC
SUPPRESSOR
(Pyrococcus
furiosus) 		4 / 8 GLY A 190
LEU A 173
LEU A 178
GLU A 179
 None
 0.82A 4mwzB-1xi6A:
undetectable		 4mwzB-1xi6A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 1xi6 EXTRAGENIC
SUPPRESSOR
(Pyrococcus
furiosus) 		6 / 11 ASP A  84
ASP A 202
ILE A 176
ILE A 203
GLY A 206
ILE A 209
 None
 1.47A 4q1xA-1xi6A:
undetectable		 4q1xA-1xi6A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1xi6 EXTRAGENIC
SUPPRESSOR
(Pyrococcus
furiosus) 		3 / 3 LEU A 173
ASP A  87
ILE A 152
 None
 0.66A 4xi3D-1xi6A:
undetectable		 4xi3D-1xi6A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1xi6 EXTRAGENIC
SUPPRESSOR
(Pyrococcus
furiosus) 		5 / 8 ILE A  93
ILE A  13
ILE A 115
ILE A  54
ASP A  84
 None
 1.41A 5hi2A-1xi6A:
undetectable		 5hi2A-1xi6A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1xi6 EXTRAGENIC
SUPPRESSOR
(Pyrococcus
furiosus) 		5 / 12 ILE A  82
VAL A  72
VAL A  70
ILE A 203
ALA A 204
 None
 1.11A 5n0sB-1xi6A:
undetectable		 5n0sB-1xi6A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_2
(PROTEASE)		 1xi6 EXTRAGENIC
SUPPRESSOR
(Pyrococcus
furiosus) 		6 / 12 LEU A 183
GLY A 214
ALA A 213
ILE A 140
GLY A 127
ILE A 208
 None
 1.36A 5t8hB-1xi6A:
undetectable		 5t8hB-1xi6A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 1xi6 EXTRAGENIC
SUPPRESSOR
(Pyrococcus
furiosus) 		6 / 12 SER A 153
VAL A 142
GLY A 186
ALA A 187
ASN A 241
GLU A 243
 None
 1.49A 6bqgA-1xi6A:
undetectable		 6bqgA-1xi6A:
13.69