SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xi8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1xi8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
(Pyrococcus
furiosus) 		5 / 12 VAL A 185
GLY A 186
GLY A 225
MET A 296
VAL A 303
 None
 0.96A 1fduC-1xi8A:
undetectable		 1fduC-1xi8A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 1xi8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
(Pyrococcus
furiosus) 		3 / 3 LEU A 309
PHE A 345
ARG A 222
 None
 0.87A 1xdkB-1xi8A:
undetectable		 1xdkB-1xi8A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1xi8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
(Pyrococcus
furiosus) 		4 / 5 LEU A 369
ILE A 365
SER A 363
GLY A 362
 None
 1.02A 2otfA-1xi8A:
undetectable		 2otfA-1xi8A:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1xi8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
(Pyrococcus
furiosus) 		4 / 8 ASN A 212
SER A 213
MET A 296
VAL A 303
 None
 1.23A 2wekA-1xi8A:
undetectable		 2wekA-1xi8A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1xi8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
(Pyrococcus
furiosus) 		4 / 8 ASN A 212
SER A 213
MET A 296
VAL A 303
 None
 1.24A 2wekB-1xi8A:
undetectable		 2wekB-1xi8A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 1xi8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
(Pyrococcus
furiosus) 		4 / 6 GLY A 158
THR A 159
LEU A 155
ASP A  43
 None
 0.98A 3ps9A-1xi8A:
4.1		 3ps9A-1xi8A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 1xi8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
(Pyrococcus
furiosus) 		5 / 10 ALA A 243
ILE A 256
GLY A 186
ILE A 228
VAL A 233
 None
 1.00A 3t3cB-1xi8A:
undetectable		 3t3cB-1xi8A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1xi8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
(Pyrococcus
furiosus) 		5 / 12 ILE A 240
LEU A 244
GLY A 258
SER A 297
GLN A 306
 None
 1.40A 4djfB-1xi8A:
undetectable		 4djfB-1xi8A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 1xi8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
(Pyrococcus
furiosus) 		4 / 7 ALA A  35
PRO A  31
LEU A 166
LEU A 161
 None
 1.03A 4iomA-1xi8A:
undetectable		 4iomA-1xi8A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1xi8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
(Pyrococcus
furiosus) 		5 / 12 MET A 296
ILE A 187
VAL A 185
LEU A 255
LEU A 219
 None
 1.14A 4m11A-1xi8A:
undetectable		 4m11A-1xi8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 1xi8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
(Pyrococcus
furiosus) 		5 / 12 GLY A 288
ILE A  16
SER A  15
LEU A 274
THR A   8
 None
 1.32A 4pooA-1xi8A:
undetectable		 4pooA-1xi8A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 1xi8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
(Pyrococcus
furiosus) 		4 / 8 LEU A  40
GLY A 158
GLU A  25
GLU A  23
 None
 0.89A 4rjdA-1xi8A:
undetectable
4rjdB-1xi8A:
undetectable		 4rjdA-1xi8A:
11.17
4rjdB-1xi8A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1xi8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
(Pyrococcus
furiosus) 		4 / 7 TYR A 396
VAL A 370
HIS A 308
LEU A 219
 None
 1.22A 4xo7B-1xi8A:
undetectable		 4xo7B-1xi8A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1xi8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
(Pyrococcus
furiosus) 		4 / 7 LEU A 315
LYS A 182
PRO A 183
GLU A 221
 None
 0.91A 4z4fA-1xi8A:
4.6		 4z4fA-1xi8A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1xi8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
(Pyrococcus
furiosus) 		4 / 6 LEU A 315
LYS A 182
PRO A 183
GLU A 221
 None
 1.01A 4z4gA-1xi8A:
4.6		 4z4gA-1xi8A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1xi8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
(Pyrococcus
furiosus) 		5 / 9 PHE A 276
ILE A  16
GLY A 290
LEU A 253
LEU A 318
 None
 1.23A 4ze0A-1xi8A:
undetectable		 4ze0A-1xi8A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1xi8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
(Pyrococcus
furiosus) 		5 / 8 PHE A 276
ILE A  16
GLY A 290
LEU A 253
LEU A 318
 None
 1.18A 5hs1A-1xi8A:
undetectable		 5hs1A-1xi8A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 1xi8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
(Pyrococcus
furiosus) 		4 / 8 HIS A 313
LEU A  18
LEU A  14
THR A 279
 None
 1.03A 5hs6A-1xi8A:
undetectable		 5hs6A-1xi8A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1xi8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
(Pyrococcus
furiosus) 		4 / 7 LEU A 315
LYS A 182
PRO A 183
GLU A 221
 None
 0.88A 5t7bA-1xi8A:
4.6		 5t7bA-1xi8A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 1xi8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
(Pyrococcus
furiosus) 		4 / 6 HIS A 308
MET A 215
VAL A 220
LEU A 216
 None
 1.03A 5xdhA-1xi8A:
0.0
5xdhC-1xi8A:
0.0		 5xdhA-1xi8A:
11.94
5xdhC-1xi8A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 1xi8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
(Pyrococcus
furiosus) 		3 / 3 TYR A 396
HIS A 308
PHE A 304
 None
 0.85A 6esmA-1xi8A:
3.6		 6esmA-1xi8A:
11.33