SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xi9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 1xi9 PUTATIVE
TRANSAMINASE
(Pyrococcus
furiosus) 		4 / 6 HIS A 369
GLY A 368
TYR A 365
GLU A 364
 None
 0.95A 1dmaB-1xi9A:
undetectable		 1dmaB-1xi9A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 1xi9 PUTATIVE
TRANSAMINASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 180
ASN A 176
LEU A  35
ARG A 371
PHE A  43
 None
 1.45A 2b9eA-1xi9A:
3.2		 2b9eA-1xi9A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 1xi9 PUTATIVE
TRANSAMINASE
(Pyrococcus
furiosus) 		5 / 11 VAL A 202
ILE A 191
ILE A 218
VAL A 231
VAL A 229
 None
 0.83A 2nnpB-1xi9A:
undetectable		 2nnpB-1xi9A:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 1xi9 PUTATIVE
TRANSAMINASE
(Pyrococcus
furiosus) 		5 / 12 ALA A 171
ILE A 109
ILE A 230
ILE A 200
LEU A 114
 None
 0.90A 2o4nA-1xi9A:
undetectable		 2o4nA-1xi9A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 1xi9 PUTATIVE
TRANSAMINASE
(Pyrococcus
furiosus) 		3 / 3 GLU A  12
GLY A 132
THR A 131
 None
 0.50A 3iazA-1xi9A:
undetectable		 3iazA-1xi9A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1xi9 PUTATIVE
TRANSAMINASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 188
VAL A 252
ILE A 163
ILE A 170
VAL A 172
 None
 0.98A 3w67B-1xi9A:
undetectable		 3w67B-1xi9A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 1xi9 PUTATIVE
TRANSAMINASE
(Pyrococcus
furiosus) 		4 / 8 TYR A 248
ASN A 233
VAL A 238
LEU A 287
 None
 1.09A 4f8hB-1xi9A:
undetectable
4f8hC-1xi9A:
undetectable		 4f8hB-1xi9A:
23.26
4f8hC-1xi9A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 1xi9 PUTATIVE
TRANSAMINASE
(Pyrococcus
furiosus) 		4 / 8 TYR A 248
ASN A 233
VAL A 238
LEU A 287
 None
 1.08A 4f8hC-1xi9A:
undetectable
4f8hD-1xi9A:
undetectable		 4f8hC-1xi9A:
23.26
4f8hD-1xi9A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 1xi9 PUTATIVE
TRANSAMINASE
(Pyrococcus
furiosus) 		4 / 8 TYR A 248
ASN A 233
VAL A 238
LEU A 287
 None
 1.09A 4f8hD-1xi9A:
undetectable
4f8hE-1xi9A:
undetectable		 4f8hD-1xi9A:
23.26
4f8hE-1xi9A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 1xi9 PUTATIVE
TRANSAMINASE
(Pyrococcus
furiosus) 		4 / 8 VAL A 238
LEU A 287
TYR A 248
ASN A 233
 None
 1.09A 4f8hA-1xi9A:
undetectable
4f8hE-1xi9A:
undetectable		 4f8hA-1xi9A:
23.26
4f8hE-1xi9A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1xi9 PUTATIVE
TRANSAMINASE
(Pyrococcus
furiosus) 		4 / 7 TYR A 127
VAL A 102
ILE A 203
ALA A 171
 PLP  A 501 (-3.8A)
PLP  A 501 (-3.7A)
None
None
 0.86A 4lv9A-1xi9A:
undetectable		 4lv9A-1xi9A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 1xi9 PUTATIVE
TRANSAMINASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 196
ALA A 195
ILE A 191
PRO A 220
VAL A 172
 None
 1.02A 4xdrA-1xi9A:
undetectable		 4xdrA-1xi9A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1xi9 PUTATIVE
TRANSAMINASE
(Pyrococcus
furiosus) 		4 / 6 GLU A 314
ASP A 347
ARG A 395
GLY A 336
 None
 0.81A 5cdnC-1xi9A:
undetectable
5cdnD-1xi9A:
undetectable		 5cdnC-1xi9A:
23.72
5cdnD-1xi9A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 1xi9 PUTATIVE
TRANSAMINASE
(Pyrococcus
furiosus) 		5 / 12 GLY A  29
ILE A  30
ILE A 380
ALA A 384
LEU A  35
 None
 1.03A 5e72A-1xi9A:
2.4		 5e72A-1xi9A:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 1xi9 PUTATIVE
TRANSAMINASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 180
ARG A 305
ILE A 329
ILE A 173
ASN A 174
 None
None
None
PLP  A 501 (-4.2A)
None
 1.15A 5fa8A-1xi9A:
3.5		 5fa8A-1xi9A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 1xi9 PUTATIVE
TRANSAMINASE
(Pyrococcus
furiosus) 		5 / 12 PRO A 220
ILE A 194
LEU A 188
VAL A 172
THR A 167
 None
 1.26A 5tiwB-1xi9A:
undetectable		 5tiwB-1xi9A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 1xi9 PUTATIVE
TRANSAMINASE
(Pyrococcus
furiosus) 		4 / 8 GLY A  71
LEU A  72
GLN A 280
ALA A 283
 None
 0.90A 5xu8A-1xi9A:
undetectable		 5xu8A-1xi9A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 1xi9 PUTATIVE
TRANSAMINASE
(Pyrococcus
furiosus) 		5 / 12 VAL A 202
ILE A 191
ILE A 218
VAL A 231
VAL A 229
 None
 0.93A 6dh0A-1xi9A:
undetectable		 6dh0A-1xi9A:
12.97