SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xio'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 1xio ANABAENA SENSORY
RHODOPSIN
(Nostoc
sp.
PCC
7120) 		4 / 7 GLN A 157
THR A 154
SER A 158
TYR A 165
 None
 1.18A 1eiiA-1xioA:
undetectable		 1eiiA-1xioA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1xio ANABAENA SENSORY
RHODOPSIN
(Nostoc
sp.
PCC
7120) 		4 / 8 LEU A  84
TYR A 165
ARG A 151
THR A 170
 None
None
PEE  A 306 (-3.9A)
None
 0.85A 2einA-1xioA:
1.7
2einJ-1xioA:
undetectable		 2einA-1xioA:
21.56
2einJ-1xioA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1xio ANABAENA SENSORY
RHODOPSIN
(Nostoc
sp.
PCC
7120) 		4 / 6 LEU A  84
TYR A 165
ARG A 151
THR A 170
 None
None
PEE  A 306 (-3.9A)
None
 0.77A 2zxwA-1xioA:
2.9
2zxwJ-1xioA:
undetectable		 2zxwA-1xioA:
21.56
2zxwJ-1xioA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1xio ANABAENA SENSORY
RHODOPSIN
(Nostoc
sp.
PCC
7120) 		4 / 6 LEU A  84
TYR A 165
ARG A 151
THR A 170
 None
None
PEE  A 306 (-3.9A)
None
 0.86A 3abmA-1xioA:
2.8
3abmJ-1xioA:
undetectable		 3abmA-1xioA:
21.56
3abmJ-1xioA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1xio ANABAENA SENSORY
RHODOPSIN
(Nostoc
sp.
PCC
7120) 		3 / 3 ARG A 155
ILE A 146
TRP A 147
 None
None
PEE  A 306 ( 3.6A)
 1.12A 3e7iB-1xioA:
undetectable		 3e7iB-1xioA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 1xio ANABAENA SENSORY
RHODOPSIN
(Nostoc
sp.
PCC
7120) 		4 / 8 TYR A  73
VAL A 182
LEU A 205
PRO A 206
 None
None
None
RET  A 301 ( 4.7A)
 1.03A 3jq7C-1xioA:
undetectable		 3jq7C-1xioA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1xio ANABAENA SENSORY
RHODOPSIN
(Nostoc
sp.
PCC
7120) 		3 / 3 ARG A 155
ILE A 146
TRP A 147
 None
None
PEE  A 306 ( 3.6A)
 1.06A 3nw2A-1xioA:
undetectable		 3nw2A-1xioA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 1xio ANABAENA SENSORY
RHODOPSIN
(Nostoc
sp.
PCC
7120) 		5 / 10 ALA A  91
LEU A  87
LEU A 105
ILE A 146
THR A 108
 None
None
None
None
PEE  A 309 ( 4.6A)
 1.32A 3r9cA-1xioA:
undetectable		 3r9cA-1xioA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 1xio ANABAENA SENSORY
RHODOPSIN
(Nostoc
sp.
PCC
7120) 		5 / 9 ILE A 141
GLY A 103
ILE A 102
ILE A 146
ILE A 142
 PEE  A 311 ( 4.5A)
None
None
None
None
 0.88A 3s45A-1xioA:
undetectable		 3s45A-1xioA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 1xio ANABAENA SENSORY
RHODOPSIN
(Nostoc
sp.
PCC
7120) 		5 / 12 LEU A  87
PHE A 213
GLN A  93
GLY A 220
LEU A 221
 None
 1.23A 4j7xB-1xioA:
undetectable		 4j7xB-1xioA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 1xio ANABAENA SENSORY
RHODOPSIN
(Nostoc
sp.
PCC
7120) 		4 / 8 PHE A 213
SER A 209
TRP A 176
TYR A 179
 None
RET  A 301 ( 4.3A)
RET  A 301 (-3.4A)
RET  A 301 (-3.5A)
 1.21A 5amiB-1xioA:
undetectable		 5amiB-1xioA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 1xio ANABAENA SENSORY
RHODOPSIN
(Nostoc
sp.
PCC
7120) 		4 / 7 GLY A 191
TRP A 183
TYR A  73
ASP A 198
 None
RET  A 301 (-3.8A)
None
None
 1.20A 5vlmG-1xioA:
undetectable		 5vlmG-1xioA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1xio ANABAENA SENSORY
RHODOPSIN
(Nostoc
sp.
PCC
7120) 		4 / 6 LEU A  84
TYR A 165
ARG A 151
THR A 170
 None
None
PEE  A 306 (-3.9A)
None
 0.83A 5x1fA-1xioA:
2.3
5x1fJ-1xioA:
undetectable		 5x1fA-1xioA:
21.56
5x1fJ-1xioA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1xio ANABAENA SENSORY
RHODOPSIN
(Nostoc
sp.
PCC
7120) 		4 / 6 LEU A  84
TYR A 165
ARG A 151
THR A 170
 None
None
PEE  A 306 (-3.9A)
None
 1.14A 6nmfN-1xioA:
1.6
6nmfW-1xioA:
undetectable		 6nmfN-1xioA:
21.56
6nmfW-1xioA:
12.67