SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xip'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBK_A_RAPA225_1
(FKBP25)		 1xip NUCLEOPORIN NUP159
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 296
VAL A 312
ILE A 313
ALA A 291
ILE A 287
 None
 0.96A 1pbkA-1xipA:
undetectable		 1pbkA-1xipA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U65_A_CP0A1000_1
(ACETYLCHOLINESTERASE)		 1xip NUCLEOPORIN NUP159
(Saccharomyces
cerevisiae) 		5 / 11 GLN A 245
TYR A 279
LEU A 324
ASP A 333
PHE A 275
 None
 1.44A 1u65A-1xipA:
undetectable		 1u65A-1xipA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 1xip NUCLEOPORIN NUP159
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 139
VAL A 169
LEU A 138
ASP A 168
 None
 1.06A 2ddwA-1xipA:
undetectable		 2ddwA-1xipA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 1xip NUCLEOPORIN NUP159
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 297
ILE A 367
THR A 334
LEU A  34
PRO A  35
 None
 1.33A 3cl9A-1xipA:
undetectable		 3cl9A-1xipA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 1xip NUCLEOPORIN NUP159
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 368
LEU A  42
PHE A  51
LEU A  78
THR A  72
 None
 1.31A 3gwuA-1xipA:
undetectable		 3gwuA-1xipA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 1xip NUCLEOPORIN NUP159
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 366
SER A 346
SER A  49
LEU A  64
 None
 1.04A 3lsfH-1xipA:
undetectable		 3lsfH-1xipA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 1xip NUCLEOPORIN NUP159
(Saccharomyces
cerevisiae) 		4 / 6 ALA A  53
ILE A  26
LEU A 368
ALA A 340
 None
 0.89A 3r9sA-1xipA:
undetectable		 3r9sA-1xipA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A206_1
(UNCHARACTERIZED
PROTEIN)		 1xip NUCLEOPORIN NUP159
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 269
TYR A 243
PRO A 268
GLY A 231
ASN A 232
 None
 1.46A 4kouA-1xipA:
0.0		 4kouA-1xipA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1xip NUCLEOPORIN NUP159
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 174
VAL A 164
VAL A 218
LEU A 160
 None
 1.02A 4puoC-1xipA:
undetectable		 4puoC-1xipA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1xip NUCLEOPORIN NUP159
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 174
VAL A 164
VAL A 218
LEU A 160
 None
 1.00A 4pwdA-1xipA:
undetectable		 4pwdA-1xipA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1xip NUCLEOPORIN NUP159
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 174
VAL A 164
VAL A 218
LEU A 160
 None
 1.00A 4q0bA-1xipA:
undetectable		 4q0bA-1xipA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D75_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 1xip NUCLEOPORIN NUP159
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 296
VAL A 312
ILE A 313
ALA A 291
ILE A 287
 None
 1.17A 5d75A-1xipA:
undetectable		 5d75A-1xipA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 1xip NUCLEOPORIN NUP159
(Saccharomyces
cerevisiae) 		5 / 11 ASN A  46
VAL A 339
ASP A  43
TYR A 279
PRO A 336
 None
 1.41A 5jh7B-1xipA:
undetectable		 5jh7B-1xipA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 1xip NUCLEOPORIN NUP159
(Saccharomyces
cerevisiae) 		5 / 11 ASN A  46
VAL A 339
ASP A  43
TYR A 279
PRO A 336
 None
 1.37A 5jh7D-1xipA:
undetectable		 5jh7D-1xipA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1xip NUCLEOPORIN NUP159
(Saccharomyces
cerevisiae) 		4 / 4 GLN A 311
THR A  10
THR A 266
LEU A 227
 None
 1.48A 5m5kA-1xipA:
undetectable		 5m5kA-1xipA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1xip NUCLEOPORIN NUP159
(Saccharomyces
cerevisiae) 		4 / 4 GLN A 311
THR A  10
THR A 266
LEU A 227
 None
 1.49A 5m5kC-1xipA:
undetectable		 5m5kC-1xipA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1xip NUCLEOPORIN NUP159
(Saccharomyces
cerevisiae) 		4 / 4 GLN A 311
THR A  10
THR A 266
LEU A 227
 None
 1.48A 5m66B-1xipA:
undetectable		 5m66B-1xipA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 1xip NUCLEOPORIN NUP159
(Saccharomyces
cerevisiae) 		4 / 9 VAL A 281
LEU A 368
VAL A  52
ASP A  43
 None
 0.99A 6c2mD-1xipA:
undetectable		 6c2mD-1xipA:
10.51