SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xiw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1xiw T-CELL SURFACE
GLYCOPROTEIN CD3
EPSILON CHAIN
(Homo
sapiens) 		5 / 10 PHE A  66
VAL A  24
VAL A  17
ASN A  41
LEU A  91
 None
 1.23A 1fe2A-1xiwA:
undetectable		 1fe2A-1xiwA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_1
(HIV-1 PROTEASE)		 1xiw IMMUNOGLOBULIN HEAVY
CHAIN VARIABLE
REGION
T-CELL SURFACE
GLYCOPROTEIN CD3
EPSILON CHAIN
(Homo
sapiens;
Mus
musculus) 		5 / 12 ASP D 104
GLY D 103
ILE A  45
GLY A  46
GLY A  47
 None
 0.86A 1hxbA-1xiwD:
undetectable		 1hxbA-1xiwD:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 1xiw IMMUNOGLOBULIN HEAVY
CHAIN VARIABLE
REGION
(Mus
musculus) 		3 / 3 ASP D  90
LEU D  84
LEU D  86
 None
 0.66A 1ikeA-1xiwD:
undetectable		 1ikeA-1xiwD:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 1xiw IMMUNOGLOBULIN HEAVY
CHAIN VARIABLE
REGION
(Mus
musculus) 		3 / 3 ASP D  90
LEU D  84
LEU D  86
 None
 0.65A 1np1B-1xiwD:
undetectable		 1np1B-1xiwD:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 1xiw T-CELL SURFACE
GLYCOPROTEIN CD3
EPSILON CHAIN
T-CELL SURFACE
GLYCOPROTEIN CD3
DELTA CHAIN
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ARG A  94
ARG A  96
ARG B  42
 None
 1.12A 2jb7A-1xiwA:
undetectable
2jb7B-1xiwA:
undetectable
2jb7C-1xiwA:
undetectable		 2jb7A-1xiwA:
19.08
2jb7B-1xiwA:
19.08
2jb7C-1xiwA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 1xiw T-CELL SURFACE
GLYCOPROTEIN CD3
EPSILON CHAIN
T-CELL SURFACE
GLYCOPROTEIN CD3
DELTA CHAIN
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ARG A  96
ARG B  42
ARG A  94
 None
 1.13A 2jb7A-1xiwA:
undetectable
2jb7B-1xiwA:
undetectable
2jb7C-1xiwA:
undetectable		 2jb7A-1xiwA:
19.08
2jb7B-1xiwA:
19.08
2jb7C-1xiwA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 1xiw T-CELL SURFACE
GLYCOPROTEIN CD3
EPSILON CHAIN
T-CELL SURFACE
GLYCOPROTEIN CD3
DELTA CHAIN
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ARG B  42
ARG A  94
ARG A  96
 None
 1.14A 2jb7A-1xiwB:
undetectable
2jb7B-1xiwB:
undetectable
2jb7C-1xiwB:
undetectable		 2jb7A-1xiwB:
18.79
2jb7B-1xiwB:
18.79
2jb7C-1xiwB:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 1xiw T-CELL SURFACE
GLYCOPROTEIN CD3
EPSILON CHAIN
IMMUNOGLOBULIN HEAVY
CHAIN VARIABLE
REGION
(Homo
sapiens;
Mus
musculus) 		3 / 3 LEU D  50
ASN D  52
ARG A  80
 None
 0.91A 2qhfA-1xiwD:
undetectable		 2qhfA-1xiwD:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 1xiw T-CELL SURFACE
GLYCOPROTEIN CD3
DELTA CHAIN
(Homo
sapiens) 		4 / 5 VAL B  12
ILE B  20
MET B   1
ARG B  47
 None
 1.40A 3oezA-1xiwB:
undetectable		 3oezA-1xiwB:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1xiw T-CELL SURFACE
GLYCOPROTEIN CD3
EPSILON CHAIN
IMMUNOGLOBULIN HEAVY
CHAIN VARIABLE
REGION
(Homo
sapiens;
Mus
musculus) 		4 / 7 GLY A  46
GLY A  47
TYR D 101
ASN D  52
 None
 1.07A 4fgkB-1xiwA:
undetectable		 4fgkB-1xiwA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_C_ACTC608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1xiw T-CELL SURFACE
GLYCOPROTEIN CD3
EPSILON CHAIN
(Homo
sapiens) 		4 / 5 TYR A  15
LYS A  12
GLN A  30
TYR A  31
 None
 1.35A 6b58C-1xiwA:
0.0		 6b58C-1xiwA:
11.58