SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xj5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		4 / 7 ASP A 153
GLY A 130
GLY A 129
GLN A  76
 None
 0.92A 1ekjE-1xj5A:
undetectable
1ekjF-1xj5A:
undetectable		 1ekjE-1xj5A:
22.06
1ekjF-1xj5A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A 128
GLY A 130
GLU A 151
ASP A 182
GLY A 183
 None
 0.45A 1jg2A-1xj5A:
8.0		 1jg2A-1xj5A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A 128
GLY A 130
GLU A 151
GLY A 183
LEU A 212
 None
 0.77A 1jg2A-1xj5A:
8.0		 1jg2A-1xj5A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		6 / 11 GLY A 128
GLY A 130
GLU A 151
ASP A 182
GLY A 183
LEU A 212
 None
 0.75A 1jg3A-1xj5A:
8.0		 1jg3A-1xj5A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		6 / 11 GLY A 128
GLY A 130
GLU A 151
ASP A 182
GLY A 183
LEU A 212
 None
 0.75A 1jg3B-1xj5A:
4.9		 1jg3B-1xj5A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A 130
GLY A 132
GLY A 133
ASP A 153
VAL A 156
 None
 0.91A 1n2xB-1xj5A:
14.1		 1n2xB-1xj5A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A 128
GLY A 130
ILE A 152
ASP A 153
ASP A 182
 None
 0.45A 1qaoA-1xj5A:
9.8		 1qaoA-1xj5A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		4 / 8 GLY A 129
GLY A 132
GLY A 133
LEU A 135
 None
 0.55A 1qzzA-1xj5A:
4.4		 1qzzA-1xj5A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A 128
GLY A 129
GLY A 130
GLU A 151
ASP A 182
 None
 0.48A 1qzzA-1xj5A:
4.4		 1qzzA-1xj5A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		5 / 12 TYR A 106
GLY A 128
GLY A 129
GLY A 130
GLU A 151
 None
 1.18A 1qzzA-1xj5A:
4.4		 1qzzA-1xj5A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		6 / 12 GLY A 132
GLY A 133
ILE A 152
ASP A 153
ASP A 182
GLY A 183
 None
 0.55A 1sqfA-1xj5A:
10.2		 1sqfA-1xj5A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		5 / 12 ALA A 318
PHE A 309
GLN A 107
PRO A 268
TYR A 262
 None
 1.45A 1u70A-1xj5A:
undetectable		 1u70A-1xj5A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A 128
GLY A 129
GLY A 130
GLU A 151
ASP A 182
 None
 0.53A 1xdsA-1xj5A:
5.3		 1xdsA-1xj5A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A 128
GLY A 129
GLY A 130
GLU A 151
ASP A 182
 None
 0.53A 1xdsB-1xj5A:
11.7		 1xdsB-1xj5A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A 130
GLY A 133
ASP A 153
ASP A 182
LEU A 212
 None
 0.74A 2hmyB-1xj5A:
7.8		 2hmyB-1xj5A:
19.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		8 / 12 TRP A  55
GLN A  97
TYR A 106
ASP A 131
GLN A 234
TYR A 270
PRO A 271
ILE A 275
 None
 0.76A 3b7pA-1xj5A:
42.8		 3b7pA-1xj5A:
46.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		8 / 12 TRP A  55
GLN A  97
TYR A 106
ASP A 204
GLN A 234
TYR A 270
PRO A 271
ILE A 275
 None
 0.76A 3b7pA-1xj5A:
42.8		 3b7pA-1xj5A:
46.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		8 / 12 TRP A  55
TYR A 106
ASP A 131
ASP A 201
GLN A 234
TYR A 270
PRO A 271
ILE A 275
 None
 0.71A 3b7pA-1xj5A:
42.8		 3b7pA-1xj5A:
46.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		8 / 12 TRP A  55
TYR A 106
ASP A 201
ASP A 204
GLN A 234
TYR A 270
PRO A 271
ILE A 275
 None
 0.65A 3b7pA-1xj5A:
42.8		 3b7pA-1xj5A:
46.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		9 / 12 TRP A  55
GLN A  97
TYR A 106
ASP A 131
ASP A 204
GLN A 234
TYR A 270
PRO A 271
ILE A 275
 None
 0.80A 3b7pB-1xj5A:
43.0		 3b7pB-1xj5A:
46.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		5 / 12 TRP A  55
GLU A 236
TYR A 270
PRO A 271
ILE A 275
 None
 1.02A 3b7pB-1xj5A:
43.0		 3b7pB-1xj5A:
46.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		9 / 12 TRP A  55
TYR A 106
ASP A 131
ASP A 201
ASP A 204
GLN A 234
TYR A 270
PRO A 271
ILE A 275
 None
 0.73A 3b7pB-1xj5A:
43.0		 3b7pB-1xj5A:
46.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		11 / 12 TRP A  55
GLN A  97
TYR A 106
ASP A 131
ASP A 201
ASP A 204
GLU A 236
SER A 237
TYR A 270
PRO A 271
ILE A 275
 None
 0.71A 3b7pC-1xj5A:
43.0		 3b7pC-1xj5A:
46.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		5 / 12 GLN A  76
TYR A 106
GLY A 129
ASP A 153
VAL A 156
 None
 0.94A 3bwcA-1xj5A:
38.9		 3bwcA-1xj5A:
40.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		9 / 12 GLN A  76
TYR A 106
ILE A 127
GLY A 128
ILE A 152
ASP A 153
VAL A 156
ASP A 182
GLY A 183
 None
 0.39A 3bwcA-1xj5A:
38.9		 3bwcA-1xj5A:
40.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		6 / 12 ILE A 127
GLY A 128
ILE A 152
VAL A 157
ASP A 182
GLY A 183
 None
 1.19A 3bwcA-1xj5A:
38.9		 3bwcA-1xj5A:
40.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		6 / 12 ILE A 127
GLY A 128
ILE A 152
VAL A 157
GLY A 183
ASP A 201
 None
 1.22A 3bwcB-1xj5A:
38.2		 3bwcB-1xj5A:
40.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		6 / 12 LEU A  92
TYR A 106
GLY A 129
ASP A 153
VAL A 156
ASP A 201
 None
 1.02A 3bwcB-1xj5A:
38.2		 3bwcB-1xj5A:
40.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		10 / 12 LEU A  92
TYR A 106
ILE A 127
GLY A 128
ASP A 131
ILE A 152
ASP A 153
VAL A 156
GLY A 183
ASP A 201
 None
 0.46A 3bwcB-1xj5A:
38.2		 3bwcB-1xj5A:
40.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_A_SPMA501_1
(SPERMINE SYNTHASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		5 / 11 TYR A 106
ASP A 131
ASP A 201
GLN A 234
TYR A 270
 None
 0.88A 3c6mA-1xj5A:
24.8		 3c6mA-1xj5A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_B_SPMB501_1
(SPERMINE SYNTHASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		5 / 9 TYR A 106
ASP A 131
ASP A 201
GLN A 234
TYR A 270
 None
 0.91A 3c6mB-1xj5A:
24.8		 3c6mB-1xj5A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_C_SPMC501_1
(SPERMINE SYNTHASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		5 / 10 TYR A 106
ASP A 131
ASP A 201
GLN A 234
TYR A 270
 None
 0.85A 3c6mC-1xj5A:
24.9		 3c6mC-1xj5A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_D_SPMD501_1
(SPERMINE SYNTHASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		5 / 10 TYR A 106
ASP A 131
ASP A 201
GLN A 234
TYR A 270
 None
 0.89A 3c6mD-1xj5A:
24.9		 3c6mD-1xj5A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A 128
GLY A 130
ILE A 152
ASP A 153
LEU A 212
 None
 0.72A 3cjtG-1xj5A:
13.1		 3cjtG-1xj5A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A 128
GLY A 130
ILE A 152
ASP A 153
LEU A 212
 None
 0.68A 3cjtO-1xj5A:
13.3		 3cjtO-1xj5A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A 128
GLY A 130
GLU A 151
ASP A 153
ASP A 182
 None
 0.45A 3fuuA-1xj5A:
11.9		 3fuuA-1xj5A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		5 / 11 GLY A 128
GLU A 151
ILE A 152
ASP A 153
ASP A 182
 None
 0.39A 3grvA-1xj5A:
12.9		 3grvA-1xj5A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		5 / 11 GLY A 128
GLY A 130
ILE A 152
ASP A 153
ASP A 182
 None
 0.71A 3grvA-1xj5A:
12.9		 3grvA-1xj5A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A 128
GLU A 151
ILE A 152
ASP A 153
ASP A 182
 None
 0.47A 3gryA-1xj5A:
12.4		 3gryA-1xj5A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A 132
GLY A 133
ASP A 153
ASP A 201
LEU A 212
 None
 0.88A 3m6vA-1xj5A:
11.1		 3m6vA-1xj5A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A 132
GLY A 133
ASP A 153
ASP A 201
LEU A 212
 None
 0.88A 3m6vB-1xj5A:
9.8		 3m6vB-1xj5A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		4 / 4 GLY A 128
GLU A 151
ASP A 182
ASP A 201
 None
 0.91A 3mb5A-1xj5A:
14.1		 3mb5A-1xj5A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB601_0
(LACCASE-1)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		4 / 4 HIS A 141
CYH A 116
ILE A 296
HIS A 112
 None
 1.35A 3qpkB-1xj5A:
undetectable		 3qpkB-1xj5A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		5 / 12 ILE A 169
GLY A 132
ASP A 201
VAL A 124
LEU A 115
 None
 1.17A 3v8vA-1xj5A:
11.7		 3v8vA-1xj5A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		4 / 6 GLY A 130
GLU A 151
ASP A 182
ASP A 201
 None
 0.75A 3vywC-1xj5A:
15.0		 3vywC-1xj5A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WFH_B_P2EB301_1
(MAB FAB H FRAGMENT
MAB FAB L FRAGMENT)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		5 / 12 VAL A 126
HIS A 141
HIS A 315
TYR A 310
GLU A 137
 None
 1.29A 3wfhA-1xj5A:
undetectable
3wfhB-1xj5A:
undetectable		 3wfhA-1xj5A:
19.47
3wfhB-1xj5A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WHX_B_XPGB301_1
(MAB FAB H FRAGMENT
MAB FAB L FRAGMENT)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		5 / 12 VAL A 126
HIS A 141
HIS A 315
TYR A 310
GLU A 137
 None
 1.30A 3whxA-1xj5A:
undetectable
3whxB-1xj5A:
undetectable		 3whxA-1xj5A:
19.41
3whxB-1xj5A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		3 / 3 GLU A 151
ASP A 153
ASP A 182
 None
 0.46A 4gc9A-1xj5A:
10.1		 4gc9A-1xj5A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A 130
GLY A 129
GLY A 128
VAL A 156
VAL A  78
 None
 0.83A 4htfA-1xj5A:
12.3		 4htfA-1xj5A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		6 / 12 GLY A 130
GLY A 129
GLY A 128
SER A 202
VAL A 156
VAL A  78
 None
 1.19A 4htfB-1xj5A:
12.3		 4htfB-1xj5A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		4 / 6 ARG A 226
ALA A 197
LEU A 115
SER A 143
 None
 0.83A 4ot2A-1xj5A:
undetectable		 4ot2A-1xj5A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUQ_A_ACTA1278_0
(NAD(P)H
DEHYDROGENASE
[QUINONE] 1)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		4 / 5 HIS A 241
GLN A 234
ILE A 275
TYR A 270
 None
 1.39A 5fuqA-1xj5A:
3.1
5fuqB-1xj5A:
2.7		 5fuqA-1xj5A:
20.48
5fuqB-1xj5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEJ_A_CUA504_0
(LACCASE 2)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		4 / 4 HIS A 141
CYH A 116
ILE A 296
HIS A 112
 None
 1.29A 5mejA-1xj5A:
undetectable		 5mejA-1xj5A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MEW_A_CUA504_0
(LACCASE 2)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		4 / 4 HIS A 141
CYH A 116
ILE A 296
HIS A 112
 None
 1.30A 5mewA-1xj5A:
undetectable		 5mewA-1xj5A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHU_A_CUA504_0
(LACCASE 2)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		4 / 4 HIS A 141
CYH A 116
ILE A 296
HIS A 112
 None
 1.31A 5mhuA-1xj5A:
undetectable		 5mhuA-1xj5A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHV_A_CUA504_0
(LACCASE 2)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		4 / 4 HIS A 141
CYH A 116
ILE A 296
HIS A 112
 None
 1.31A 5mhvA-1xj5A:
undetectable		 5mhvA-1xj5A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA604_0
(LACCASE 2)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		4 / 4 HIS A 141
CYH A 116
ILE A 296
HIS A 112
 None
 1.31A 5mhwA-1xj5A:
undetectable		 5mhwA-1xj5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA604_0
(LACCASE 2)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		4 / 4 HIS A 141
CYH A 116
ILE A 296
HIS A 112
 None
 1.31A 5mhxA-1xj5A:
undetectable		 5mhxA-1xj5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA604_0
(LACCASE 2)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		4 / 4 HIS A 141
CYH A 116
ILE A 296
HIS A 112
 None
 1.31A 5mhyA-1xj5A:
undetectable		 5mhyA-1xj5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA604_0
(LACCASE 2)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		4 / 4 HIS A 141
CYH A 116
ILE A 296
HIS A 112
 None
 1.31A 5mhzA-1xj5A:
undetectable		 5mhzA-1xj5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA604_0
(LACCASE 2)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		4 / 4 HIS A 141
CYH A 116
ILE A 296
HIS A 112
 None
 1.31A 5mi1A-1xj5A:
undetectable		 5mi1A-1xj5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA604_0
(LACCASE 2)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		4 / 4 HIS A 141
CYH A 116
ILE A 296
HIS A 112
 None
 1.31A 5mi2A-1xj5A:
undetectable		 5mi2A-1xj5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA604_0
(LACCASE 2)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		4 / 4 HIS A 141
CYH A 116
ILE A 296
HIS A 112
 None
 1.31A 5miaA-1xj5A:
undetectable		 5miaA-1xj5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA604_0
(LACCASE 2)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		4 / 4 HIS A 141
CYH A 116
ILE A 296
HIS A 112
 None
 1.31A 5mibA-1xj5A:
undetectable		 5mibA-1xj5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA604_0
(LACCASE 2)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		4 / 4 HIS A 141
CYH A 116
ILE A 296
HIS A 112
 None
 1.31A 5micA-1xj5A:
undetectable		 5micA-1xj5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA604_0
(LACCASE 2)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		4 / 4 HIS A 141
CYH A 116
ILE A 296
HIS A 112
 None
 1.31A 5midA-1xj5A:
undetectable		 5midA-1xj5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA604_0
(LACCASE 2)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		4 / 4 HIS A 141
CYH A 116
ILE A 296
HIS A 112
 None
 1.31A 5mieA-1xj5A:
undetectable		 5mieA-1xj5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA604_0
(LACCASE 2)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		4 / 4 HIS A 141
CYH A 116
ILE A 296
HIS A 112
 None
 1.31A 5migA-1xj5A:
undetectable		 5migA-1xj5A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		3 / 3 ILE A 147
VAL A 124
PRO A 121
 None
 0.68A 5uunA-1xj5A:
undetectable		 5uunA-1xj5A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		5 / 8 LEU A 125
VAL A 221
ILE A 127
GLY A 128
ILE A 248
 None
 1.15A 5vkqB-1xj5A:
undetectable
5vkqC-1xj5A:
undetectable		 5vkqB-1xj5A:
10.67
5vkqC-1xj5A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		4 / 7 ILE A 275
PHE A 309
ILE A 329
ALA A 317
 None
 0.85A 6b5vA-1xj5A:
undetectable
6b5vC-1xj5A:
undetectable		 6b5vA-1xj5A:
11.82
6b5vC-1xj5A:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		4 / 7 ALA A 317
ILE A 275
PHE A 309
ILE A 329
 None
 0.83A 6b5vA-1xj5A:
undetectable
6b5vB-1xj5A:
undetectable		 6b5vA-1xj5A:
11.82
6b5vB-1xj5A:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		4 / 7 ILE A 275
PHE A 309
ILE A 329
ALA A 317
 None
 0.85A 6b5vC-1xj5A:
undetectable
6b5vD-1xj5A:
undetectable		 6b5vC-1xj5A:
11.82
6b5vD-1xj5A:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		4 / 7 ALA A 317
ILE A 275
PHE A 309
ILE A 329
 None
 0.86A 6b5vB-1xj5A:
undetectable
6b5vD-1xj5A:
undetectable		 6b5vB-1xj5A:
11.82
6b5vD-1xj5A:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		6 / 12 GLN A  76
GLY A 128
ILE A 152
ASP A 153
VAL A 156
ASP A 182
 None
 0.32A 6bq4A-1xj5A:
35.2		 6bq4A-1xj5A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A 128
ILE A 152
ASP A 153
VAL A 156
LEU A 212
 None
 0.77A 6bq4A-1xj5A:
35.2		 6bq4A-1xj5A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		5 / 12 GLN A  76
GLY A 128
ILE A 152
ASP A 153
ALA A 209
 None
 1.11A 6bq4B-1xj5A:
35.4		 6bq4B-1xj5A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		6 / 12 GLN A  76
GLY A 128
ILE A 152
ASP A 153
VAL A 156
ASP A 182
 None
 0.31A 6bq4B-1xj5A:
35.4		 6bq4B-1xj5A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		5 / 12 GLY A 129
SER A  73
GLN A  76
ILE A 152
ASP A 182
 None
 1.31A 6bxnB-1xj5A:
3.2		 6bxnB-1xj5A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 1xj5 SPERMIDINE SYNTHASE
1
(Arabidopsis
thaliana) 		5 / 12 ILE A 127
GLY A 128
GLY A 130
ILE A 152
ASP A 153
 None
 0.36A 6iftA-1xj5A:
10.5		 6iftA-1xj5A:
21.57