SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xje'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		3 / 3 ALA A  49
VAL A  44
TRP A  41
 None
 0.64A 1av2C-1xjeA:
undetectable
1av2D-1xjeA:
undetectable		 1av2C-1xjeA:
1.74
1av2D-1xjeA:
1.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 9 ASN A 593
LEU A 327
GLY A 323
ALA A 489
LEU A 335
 None
None
None
GDP  A1002 (-3.4A)
None
 1.15A 1e7bA-1xjeA:
undetectable		 1e7bA-1xjeA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 12 ASP A  25
ALA A 498
SER A 495
TRP A  41
LEU A  82
 None
 1.41A 1kiaD-1xjeA:
undetectable		 1kiaD-1xjeA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		4 / 7 PHE A 167
PHE A 194
PHE A 241
VAL A 137
 None
 0.99A 1lh6A-1xjeA:
undetectable		 1lh6A-1xjeA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 8 ASP A 339
ALA A 498
ASP A 499
ILE A  88
GLY A 492
 None
None
None
None
GDP  A1002 (-3.8A)
 1.48A 1sh9A-1xjeA:
undetectable		 1sh9A-1xjeA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		3 / 3 ALA A  49
VAL A  44
TRP A  41
 None
 0.64A 1w5uC-1xjeA:
undetectable
1w5uD-1xjeA:
undetectable		 1w5uC-1xjeA:
1.74
1w5uD-1xjeA:
1.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 11 ILE A 625
GLY A 323
THR A 319
THR A 626
GLY A 624
 None
 1.15A 2fn1B-1xjeA:
undetectable		 2fn1B-1xjeA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		3 / 3 TRP A  41
ALA A  49
VAL A  44
 None
 0.79A 2izqA-1xjeA:
undetectable
2izqB-1xjeA:
undetectable		 2izqA-1xjeA:
1.74
2izqB-1xjeA:
1.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_A_IPHA2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		4 / 5 HIS A 428
TYR A 449
TYR A 307
PRO A 309
 None
 1.26A 2ombA-1xjeA:
undetectable
2ombB-1xjeA:
undetectable		 2ombA-1xjeA:
16.14
2ombB-1xjeA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 11 LEU A 357
ILE A 423
ALA A 427
GLU A 324
LEU A 365
 None
None
None
GDP  A1002 (-2.6A)
None
 1.37A 2v0mA-1xjeA:
undetectable		 2v0mA-1xjeA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		4 / 8 LEU A 399
PHE A 587
MET A 583
PHE A 415
 None
 0.76A 2weyB-1xjeA:
undetectable		 2weyB-1xjeA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 12 THR A 157
SER A 318
THR A 319
ASN A 320
GLY A 161
 None
None
None
GDP  A1002 (-3.7A)
GDP  A1002 (-4.4A)
 1.23A 2x2iA-1xjeA:
2.0		 2x2iA-1xjeA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		3 / 3 GLU A 468
ASP A 466
TYR A 590
 None
 0.72A 2yvlB-1xjeA:
undetectable		 2yvlB-1xjeA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 12 LEU A 486
THR A 487
ALA A 427
THR A 430
ASN A 482
 None
 1.21A 3a35A-1xjeA:
undetectable		 3a35A-1xjeA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 12 LEU A 486
THR A 487
ALA A 427
THR A 430
ASN A 482
 None
 1.12A 3a35B-1xjeA:
undetectable		 3a35B-1xjeA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 12 LEU A 486
THR A 487
ALA A 427
THR A 430
ASN A 482
 None
 1.19A 3a3bA-1xjeA:
undetectable		 3a3bA-1xjeA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 10 ILE A 488
GLY A 503
LEU A 400
MET A 420
MET A 583
 None
 1.27A 3adsA-1xjeA:
undetectable		 3adsA-1xjeA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 12 LEU A 389
ASN A 482
ALA A 382
THR A  93
VAL A  52
 None
 1.11A 3c6gB-1xjeA:
undetectable		 3c6gB-1xjeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 12 LEU A 389
ASN A 482
ALA A 382
THR A  93
VAL A  52
 None
 1.06A 3czhB-1xjeA:
undetectable		 3czhB-1xjeA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 12 LEU A 351
LEU A 354
LEU A 357
LEU A 391
TYR A 465
 None
 1.19A 3d90B-1xjeA:
undetectable		 3d90B-1xjeA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 12 LEU A  23
ARG A  85
ILE A 360
VAL A  44
LEU A  94
 None
 1.05A 3gwxB-1xjeA:
undetectable		 3gwxB-1xjeA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		4 / 5 PRO A 490
SER A 502
LEU A 335
SER A 337
 GDP  A1002 (-3.9A)
None
None
None
 1.29A 3ijxH-1xjeA:
undetectable		 3ijxH-1xjeA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 12 ILE A 599
ALA A 290
PRO A 602
VAL A 613
ASN A 612
 None
 0.97A 3jb3A-1xjeA:
undetectable		 3jb3A-1xjeA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		3 / 3 ASN A 600
ASP A 630
ARG A 514
 None
 0.93A 3k13C-1xjeA:
3.5		 3k13C-1xjeA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 12 GLY A 323
VAL A 613
GLY A 297
PHE A 300
ALA A 617
 None
 1.08A 3keeC-1xjeA:
undetectable		 3keeC-1xjeA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		3 / 3 ALA A  49
VAL A  44
TRP A  41
 None
 0.77A 3l8lA-1xjeA:
undetectable
3l8lB-1xjeA:
undetectable		 3l8lA-1xjeA:
1.74
3l8lB-1xjeA:
1.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		3 / 3 ALA A  49
VAL A  44
TRP A  41
 None
 0.68A 3l8lC-1xjeA:
undetectable
3l8lD-1xjeA:
undetectable		 3l8lC-1xjeA:
1.74
3l8lD-1xjeA:
1.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O0Q_A_ADNA1004_1
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		8 / 9 MET A 212
ASN A 242
SER A 244
ASP A 295
GLY A 297
CYH A 322
SER A 596
THR A 626
 None
None
None
None
None
GDP  A1002 (-3.6A)
None
None
 0.54A 3o0qA-1xjeA:
66.1		 3o0qA-1xjeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O0Q_A_ADNA1004_1
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		8 / 9 MET A 212
ASN A 242
SER A 244
ASP A 295
GLY A 297
CYH A 322
THR A 598
THR A 626
 None
None
None
None
None
GDP  A1002 (-3.6A)
None
None
 0.15A 3o0qA-1xjeA:
66.1		 3o0qA-1xjeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O0Q_B_ADNB1004_1
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		9 / 9 MET A 212
ASN A 242
SER A 244
ASP A 295
CYH A 322
PRO A 490
SER A 596
THR A 598
THR A 626
 None
None
None
None
GDP  A1002 (-3.6A)
GDP  A1002 (-3.9A)
None
None
None
 0.55A 3o0qB-1xjeA:
63.7		 3o0qB-1xjeA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 11 VAL A 136
PHE A 374
GLY A 161
GLY A 160
ASN A  96
 None
None
GDP  A1002 (-4.4A)
GDP  A1002 ( 4.7A)
None
 1.36A 3owxA-1xjeA:
undetectable
3owxB-1xjeA:
undetectable		 3owxA-1xjeA:
16.54
3owxB-1xjeA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 11 VAL A 137
PHE A 374
GLY A 161
GLY A 160
ASN A  96
 None
None
GDP  A1002 (-4.4A)
GDP  A1002 ( 4.7A)
None
 1.38A 3owxA-1xjeA:
undetectable
3owxB-1xjeA:
undetectable		 3owxA-1xjeA:
16.54
3owxB-1xjeA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 12 VAL A  52
PHE A  87
ILE A 494
LEU A  94
VAL A  48
 None
None
GDP  A1002 (-3.9A)
None
None
 1.02A 3w68B-1xjeA:
1.2		 3w68B-1xjeA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		4 / 7 LEU A  99
ASN A  96
VAL A  48
ILE A  22
 None
 0.88A 4eyrA-1xjeA:
undetectable		 4eyrA-1xjeA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		4 / 8 ASN A  90
GLY A 390
THR A 487
GLY A 323
 None
 0.86A 4fo4B-1xjeA:
2.1		 4fo4B-1xjeA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		3 / 3 ARG A 480
HIS A 428
TYR A 449
 None
 1.14A 4fu8A-1xjeA:
undetectable		 4fu8A-1xjeA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		3 / 3 ARG A 480
HIS A 428
TYR A 449
 None
 1.18A 4fu9A-1xjeA:
undetectable		 4fu9A-1xjeA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		4 / 4 ILE A   7
SER A   8
ASP A  76
ASP A 111
 None
 1.18A 4krhB-1xjeA:
undetectable		 4krhB-1xjeA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 12 ALA A 617
TYR A 614
VAL A 613
PHE A 247
GLY A 624
 None
 1.15A 4mm4B-1xjeA:
0.0		 4mm4B-1xjeA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 9 ALA A 617
TYR A 614
GLY A 246
PHE A 247
GLY A 624
 None
 1.17A 4mm5A-1xjeA:
undetectable		 4mm5A-1xjeA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 12 ALA A 617
TYR A 614
GLY A 246
PHE A 247
GLY A 624
 None
 1.16A 4mm8A-1xjeA:
undetectable		 4mm8A-1xjeA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 11 ALA A 617
TYR A 614
GLY A 246
PHE A 247
GLY A 624
 None
 1.30A 4mm9A-1xjeA:
undetectable		 4mm9A-1xjeA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 10 ALA A 617
TYR A 614
GLY A 246
PHE A 247
GLY A 624
 None
 1.13A 4mmdA-1xjeA:
undetectable		 4mmdA-1xjeA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 12 ALA A 617
TYR A 614
GLY A 246
PHE A 247
GLY A 624
 None
 1.10A 4mmdB-1xjeA:
undetectable		 4mmdB-1xjeA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 9 ALA A 617
TYR A 614
GLY A 246
PHE A 247
GLY A 624
 None
 1.16A 4mmeA-1xjeA:
undetectable		 4mmeA-1xjeA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 9 ALA A 617
TYR A 614
GLY A 246
PHE A 247
GLY A 624
 None
 1.27A 4mmeB-1xjeA:
undetectable		 4mmeB-1xjeA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 9 ALA A 617
TYR A 614
GLY A 246
PHE A 247
GLY A 624
 None
 1.14A 4mmfA-1xjeA:
undetectable		 4mmfA-1xjeA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 9 ALA A 617
TYR A 614
GLY A 246
PHE A 247
GLY A 624
 None
 1.15A 4mmfB-1xjeA:
undetectable		 4mmfB-1xjeA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		3 / 3 PRO A 296
LEU A 243
HIS A 192
 None
 0.69A 4pevA-1xjeA:
2.2		 4pevA-1xjeA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 12 ASN A 372
GLY A 160
PHE A 374
ALA A 332
VAL A 383
 None
GDP  A1002 ( 4.7A)
None
None
None
 1.47A 4ryaA-1xjeA:
undetectable		 4ryaA-1xjeA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		4 / 7 ILE A 222
HIS A 192
LEU A 238
LEU A 243
 None
 1.00A 4xo7A-1xjeA:
2.9		 4xo7A-1xjeA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 11 VAL A 136
PHE A 374
GLY A 161
GLY A 160
ASN A  96
 None
None
GDP  A1002 (-4.4A)
GDP  A1002 ( 4.7A)
None
 1.41A 4zvmA-1xjeA:
undetectable
4zvmB-1xjeA:
undetectable		 4zvmA-1xjeA:
16.06
4zvmB-1xjeA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 11 VAL A 137
PHE A 374
GLY A 161
GLY A 160
ASN A  96
 None
None
GDP  A1002 (-4.4A)
GDP  A1002 ( 4.7A)
None
 1.37A 4zvmA-1xjeA:
undetectable
4zvmB-1xjeA:
undetectable		 4zvmA-1xjeA:
16.06
4zvmB-1xjeA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		4 / 7 ILE A 541
ARG A 544
VAL A 561
ILE A 558
 None
 1.00A 4zzbC-1xjeA:
undetectable
4zzbD-1xjeA:
undetectable		 4zzbC-1xjeA:
18.73
4zzbD-1xjeA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		4 / 5 ALA A 397
HIS A 580
ALA A 572
GLU A 505
 None
 1.44A 5a06C-1xjeA:
undetectable
5a06D-1xjeA:
undetectable		 5a06C-1xjeA:
20.60
5a06D-1xjeA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		4 / 7 ALA A 210
GLU A 324
GLY A 162
GLY A 164
 GDP  A1002 (-3.4A)
GDP  A1002 (-2.6A)
GDP  A1002 ( 3.8A)
None
 0.81A 5e26A-1xjeA:
undetectable
5e26B-1xjeA:
2.1		 5e26A-1xjeA:
21.27
5e26B-1xjeA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		4 / 7 GLU A 324
GLY A 162
GLY A 164
ALA A 210
 GDP  A1002 (-2.6A)
GDP  A1002 ( 3.8A)
None
GDP  A1002 (-3.4A)
 0.84A 5e26C-1xjeA:
2.1
5e26D-1xjeA:
1.3		 5e26C-1xjeA:
21.27
5e26D-1xjeA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		3 / 3 ARG A 514
ASN A 496
ASP A 339
 None
 0.75A 5gwxA-1xjeA:
undetectable		 5gwxA-1xjeA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		4 / 7 GLY A 323
GLU A 324
ALA A 489
ASN A 242
 None
GDP  A1002 (-2.6A)
GDP  A1002 (-3.4A)
None
 0.87A 5mvsA-1xjeA:
undetectable		 5mvsA-1xjeA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		4 / 8 GLY A 323
GLU A 324
ALA A 489
ASN A 242
 None
GDP  A1002 (-2.6A)
GDP  A1002 (-3.4A)
None
 0.85A 5mvsB-1xjeA:
undetectable		 5mvsB-1xjeA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 12 ILE A 625
GLY A 297
VAL A 245
PHE A 247
ALA A 617
 None
 1.16A 5n0oA-1xjeA:
undetectable		 5n0oA-1xjeA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 12 ILE A 625
GLY A 297
VAL A 245
PHE A 247
ALA A 617
 None
 1.15A 5n0rA-1xjeA:
undetectable		 5n0rA-1xjeA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 12 ILE A 625
GLY A 297
VAL A 245
PHE A 247
ALA A 617
 None
 1.15A 5n0wA-1xjeA:
undetectable		 5n0wA-1xjeA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		3 / 3 THR A  93
MET A 130
HIS A 129
 None
 1.02A 5uunA-1xjeA:
undetectable		 5uunA-1xjeA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 12 MET A 420
ALA A 424
GLU A 356
LEU A 354
VAL A 362
 None
 1.20A 5vlmE-1xjeA:
undetectable		 5vlmE-1xjeA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		4 / 5 ASN A 496
TYR A 512
VAL A 529
LEU A 527
 None
 1.31A 6a7pA-1xjeA:
undetectable		 6a7pA-1xjeA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		5 / 12 ILE A 625
THR A 319
VAL A 136
GLU A 324
GLU A 505
 None
None
None
GDP  A1002 (-2.6A)
None
 1.41A 6bzoC-1xjeA:
0.5		 6bzoC-1xjeA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		4 / 5 ILE A 494
THR A 491
THR A  93
LEU A 365
 GDP  A1002 (-3.9A)
GDP  A1002 (-4.7A)
None
None
 1.08A 6f3mD-1xjeA:
undetectable		 6f3mD-1xjeA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		4 / 6 ILE A 286
TYR A 614
LEU A 611
ARG A 284
 None
 1.18A 6f6jA-1xjeA:
undetectable		 6f6jA-1xjeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT
(Thermotoga
maritima) 		3 / 3 VAL A 622
ALA A 617
GLN A 584
 None
 0.68A 6gb9A-1xjeA:
1.5		 6gb9A-1xjeA:
21.84