SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xjl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_B_DOLB301_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 1xjl ANNEXIN A2
(Homo
sapiens) 		5 / 12 ILE A  42
LEU A 102
LEU A  91
ASN A  65
TYR A 109
 None
 1.49A 1mrlB-1xjlA:
undetectable
1mrlC-1xjlA:
undetectable		 1mrlB-1xjlA:
21.40
1mrlC-1xjlA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1xjl ANNEXIN A2
(Homo
sapiens) 		3 / 3 ASP A  38
ASP A  70
ASN A  62
 None
 0.73A 2bm9D-1xjlA:
undetectable		 2bm9D-1xjlA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 1xjl ANNEXIN A2
(Homo
sapiens) 		5 / 12 ILE A 291
TYR A 109
LEU A 315
SER A 296
ASP A 322
 None
None
None
None
CA  A 345 (-2.2A)
 1.40A 2iyfB-1xjlA:
undetectable		 2iyfB-1xjlA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 1xjl ANNEXIN A2
(Homo
sapiens) 		5 / 12 VAL A  98
ILE A 291
TYR A 109
LEU A 315
SER A 296
 None
 1.42A 2iyfB-1xjlA:
undetectable		 2iyfB-1xjlA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_2
(PROTEASE)		 1xjl ANNEXIN A2
(Homo
sapiens) 		5 / 11 GLY A 202
ALA A 201
ASP A 200
ASP A 197
ILE A 216
 CA  A 343 (-4.6A)
None
None
None
None
 1.10A 3ebzB-1xjlA:
undetectable		 3ebzB-1xjlA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_1
(PROTEASE)		 1xjl ANNEXIN A2
(Homo
sapiens) 		5 / 12 GLY A 202
ALA A 201
ASP A 200
ASP A 197
ILE A 216
 CA  A 343 (-4.6A)
None
None
None
None
 1.15A 3s56A-1xjlA:
undetectable		 3s56A-1xjlA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 1xjl ANNEXIN A2
(Homo
sapiens) 		5 / 11 VAL A  98
ILE A 291
TYR A 109
LEU A 315
SER A 296
 None
 1.44A 4m83A-1xjlA:
undetectable		 4m83A-1xjlA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 1xjl ANNEXIN A2
(Homo
sapiens) 		4 / 6 VAL A 298
ASP A 299
SER A 134
ALA A 271
 None
 1.17A 4nedA-1xjlA:
undetectable		 4nedA-1xjlA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 1xjl ANNEXIN A2
(Homo
sapiens) 		5 / 12 LEU A 174
ILE A 263
ALA A 255
PHE A 256
MET A 240
 None
 1.16A 4rp8C-1xjlA:
undetectable		 4rp8C-1xjlA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1xjl ANNEXIN A2
(Homo
sapiens) 		3 / 3 VAL A  98
LEU A 102
VAL A 293
 None
 0.57A 4wq4A-1xjlA:
undetectable		 4wq4A-1xjlA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 1xjl ANNEXIN A2
(Homo
sapiens) 		4 / 5 GLY A 337
TYR A 317
SER A 314
ASP A 339
 None
 1.15A 4xueA-1xjlA:
undetectable		 4xueA-1xjlA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 1xjl ANNEXIN A2
(Homo
sapiens) 		5 / 12 LEU A 252
LEU A 170
LEU A 174
ASN A 258
LEU A 259
 None
 0.96A 5nfjA-1xjlA:
undetectable		 5nfjA-1xjlA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 1xjl ANNEXIN A2
(Homo
sapiens) 		5 / 12 LEU A 252
LEU A 170
LEU A 174
ASN A 258
LEU A 259
 None
 0.95A 5nfjB-1xjlA:
undetectable		 5nfjB-1xjlA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 1xjl ANNEXIN A2
(Homo
sapiens) 		5 / 12 LEU A 252
LEU A 170
LEU A 174
ASN A 258
LEU A 259
 None
 0.97A 5nfjC-1xjlA:
undetectable		 5nfjC-1xjlA:
20.99