SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xk5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1xk5 SNURPORTIN-1
(Homo
sapiens) 		5 / 11 LEU A 115
VAL A 285
VAL A 288
GLY A 287
LEU A 108
 None
 1.38A 1lwcA-1xk5A:
undetectable		 1lwcA-1xk5A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1xk5 SNURPORTIN-1
(Homo
sapiens) 		5 / 10 LEU A 115
VAL A 285
VAL A 288
GLY A 287
LEU A 108
 None
 1.37A 2hnyA-1xk5A:
undetectable		 2hnyA-1xk5A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1xk5 SNURPORTIN-1
(Homo
sapiens) 		4 / 5 LEU A 273
GLN A 263
THR A 264
LEU A 115
 None
 0.93A 3ce6D-1xk5A:
undetectable		 3ce6D-1xk5A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP0_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1xk5 SNURPORTIN-1
(Homo
sapiens) 		5 / 9 LEU A 115
VAL A 285
VAL A 288
GLY A 287
LEU A 108
 None
 1.28A 3lp0A-1xk5A:
0.0		 3lp0A-1xk5A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1xk5 SNURPORTIN-1
(Homo
sapiens) 		5 / 10 LEU A 115
VAL A 285
VAL A 288
GLY A 287
LEU A 108
 None
 1.37A 3lp1A-1xk5A:
undetectable		 3lp1A-1xk5A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 1xk5 SNURPORTIN-1
(Homo
sapiens) 		5 / 12 LEU A 115
VAL A 285
VAL A 288
GLY A 287
LEU A 108
 None
 1.27A 3mecA-1xk5A:
undetectable		 3mecA-1xk5A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 1xk5 SNURPORTIN-1
(Homo
sapiens) 		5 / 12 LEU A 115
VAL A 285
VAL A 288
GLY A 287
LEU A 108
 None
 1.24A 3medA-1xk5A:
undetectable
3medB-1xk5A:
undetectable		 3medA-1xk5A:
15.72
3medB-1xk5A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 1xk5 SNURPORTIN-1
(Homo
sapiens) 		5 / 7 GLY A 159
GLY A 158
SER A 154
LEU A 172
PHE A 229
 None
 1.22A 3o9mA-1xk5A:
undetectable		 3o9mA-1xk5A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 1xk5 SNURPORTIN-1
(Homo
sapiens) 		5 / 12 VAL A 282
VAL A 121
LEU A 257
GLY A 116
LEU A 242
 None
 1.28A 3pghA-1xk5A:
undetectable		 3pghA-1xk5A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1xk5 SNURPORTIN-1
(Homo
sapiens) 		3 / 3 LYS A 233
LEU A 258
ILE A 175
 None
TPG  A 400 (-4.6A)
None
 0.78A 5kc4A-1xk5A:
undetectable		 5kc4A-1xk5A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_1
(-)		 1xk5 SNURPORTIN-1
(Homo
sapiens) 		5 / 12 LEU A 186
ASP A 173
LEU A 104
GLY A 275
PHE A 205
 None
None
TPG  A 400 ( 4.0A)
None
None
 1.32A 6gbnB-1xk5A:
undetectable		 6gbnB-1xk5A:
16.44