SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xk8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 1xk8 DIVALENT CATION
TOLERANT PROTEIN
CUTA
(Homo
sapiens) 		4 / 8 ILE A  61
ARG A 115
THR A 111
LEU A 110
 None
 0.71A 3hrdA-1xk8A:
undetectable
3hrdB-1xk8A:
undetectable		 3hrdA-1xk8A:
15.40
3hrdB-1xk8A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 1xk8 DIVALENT CATION
TOLERANT PROTEIN
CUTA
(Homo
sapiens) 		3 / 3 PHE A 135
LYS A  40
SER A  44
 None
 1.11A 3tyeB-1xk8A:
undetectable		 3tyeB-1xk8A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 1xk8 DIVALENT CATION
TOLERANT PROTEIN
CUTA
(Homo
sapiens) 		4 / 7 GLU A  95
GLN A  79
PRO A 119
TYR A 120
 None
 1.23A 3ugrA-1xk8A:
undetectable		 3ugrA-1xk8A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1xk8 DIVALENT CATION
TOLERANT PROTEIN
CUTA
(Homo
sapiens) 		3 / 3 PHE A  49
VAL A  65
ILE A  61
 None
 0.53A 4emaA-1xk8A:
undetectable		 4emaA-1xk8A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1xk8 DIVALENT CATION
TOLERANT PROTEIN
CUTA
(Homo
sapiens) 		4 / 8 ILE A  61
ALA A  48
VAL A 125
VAL A  65
 None
 0.72A 5ecnD-1xk8A:
undetectable		 5ecnD-1xk8A:
12.85