SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xkn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		5 / 12 THR A  18
THR A 341
VAL A  53
LEU A 297
ILE A 325
 None
 1.21A 1kqwA-1xknA:
undetectable		 1kqwA-1xknA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		3 / 3 GLU A 227
ASN A 163
TRP A  12
 None
 1.03A 1r15C-1xknA:
undetectable		 1r15C-1xknA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		3 / 3 GLU A 227
ASN A 163
TRP A  12
 None
 1.00A 1r15D-1xknA:
undetectable		 1r15D-1xknA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		3 / 3 GLU A 227
ASN A 163
TRP A  12
 None
 1.02A 1r15E-1xknA:
undetectable		 1r15E-1xknA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		3 / 3 GLU A 227
ASN A 163
TRP A  12
 None
 1.00A 1r15F-1xknA:
undetectable		 1r15F-1xknA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		4 / 7 VAL A 231
CYH A 303
CYH A 316
ARG A 320
 None
None
None
CL  A 800 (-4.2A)
 1.11A 1t46A-1xknA:
undetectable		 1t46A-1xknA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		5 / 8 LEU A  43
GLN A  46
ILE A 337
THR A  18
LEU A  47
 None
 1.32A 2xfhA-1xknA:
undetectable		 2xfhA-1xknA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		4 / 6 LEU A 297
ILE A 325
ARG A  73
VAL A 140
 None
 1.18A 2ygoA-1xknA:
undetectable		 2ygoA-1xknA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		3 / 3 SER A  48
GLU A  81
ASP A  74
 None
 0.81A 2zthA-1xknA:
4.3		 2zthA-1xknA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		3 / 3 MET A   8
GLU A  11
ASN A 288
 None
 1.09A 3a27A-1xknA:
undetectable		 3a27A-1xknA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		5 / 10 TYR A 286
ASN A 288
ALA A 336
LEU A 313
PHE A 317
 None
 1.15A 3ay0A-1xknA:
2.7		 3ay0A-1xknA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		3 / 3 SER A  48
GLU A  81
ASP A  74
 None
 0.85A 3bwmA-1xknA:
2.3		 3bwmA-1xknA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		3 / 3 SER A  48
GLU A  81
ASP A  74
 None
 0.81A 3bwyA-1xknA:
undetectable		 3bwyA-1xknA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		4 / 7 HIS A  98
LEU A  47
PHE A  40
VAL A  36
 None
 1.04A 3jwqC-1xknA:
undetectable		 3jwqC-1xknA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		5 / 12 ASN A 288
VAL A  36
ALA A  41
ALA A  44
LEU A  20
 None
 0.93A 3mteB-1xknA:
undetectable		 3mteB-1xknA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MYU_A_VIBA500_1
(HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37)		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		5 / 10 ASP A 213
ASN A 288
ASP A  97
ASP A 220
GLY A 216
 None
 1.36A 3myuA-1xknA:
undetectable		 3myuA-1xknA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		5 / 12 LEU A 193
VAL A 218
GLY A 158
ALA A 159
LEU A 155
 None
 1.08A 3nt1A-1xknA:
undetectable		 3nt1A-1xknA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		5 / 12 LEU A 193
VAL A 218
GLY A 158
ALA A 159
LEU A 155
 None
 1.06A 3nt1B-1xknA:
undetectable		 3nt1B-1xknA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		4 / 6 GLU A 280
GLY A 279
LEU A 282
TYR A 277
 None
 1.15A 3w9tB-1xknA:
undetectable		 3w9tB-1xknA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		4 / 6 GLU A 280
GLY A 279
LEU A 282
TYR A 277
 None
 1.16A 3w9tE-1xknA:
undetectable		 3w9tE-1xknA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		4 / 6 CYH A 339
THR A 341
GLY A 158
ASP A 219
 None
 1.35A 3w9tE-1xknA:
undetectable		 3w9tE-1xknA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		4 / 6 GLU A 280
GLY A 279
LEU A 282
TYR A 277
 None
 1.15A 3w9tF-1xknA:
undetectable		 3w9tF-1xknA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		4 / 7 GLY A 125
GLY A 124
ASN A 177
GLU A 128
 None
 0.96A 4fgkB-1xknA:
undetectable		 4fgkB-1xknA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		4 / 8 ILE A 189
LEU A 175
ILE A 199
GLY A 157
 None
 0.85A 4hb8A-1xknA:
undetectable		 4hb8A-1xknA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		3 / 3 ASP A 133
TRP A  29
SER A  21
 None
 1.01A 4lrhB-1xknA:
undetectable		 4lrhB-1xknA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		3 / 3 ASP A 133
TRP A  29
SER A  21
 None
 0.98A 4lrhF-1xknA:
undetectable		 4lrhF-1xknA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		4 / 8 LEU A 169
VAL A 230
ILE A 232
MET A 256
 None
 0.87A 4oj4A-1xknA:
undetectable		 4oj4A-1xknA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		3 / 3 GLY A  99
PRO A 100
ALA A 141
 None
 0.47A 4qn9B-1xknA:
undetectable		 4qn9B-1xknA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		3 / 3 SER A  48
GLU A  81
ASP A  74
 None
 0.82A 4xudA-1xknA:
2.1		 4xudA-1xknA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		5 / 12 HIS A 217
ILE A 160
VAL A 154
LEU A 197
THR A 151
 None
 1.26A 5bykA-1xknA:
undetectable		 5bykA-1xknA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		4 / 8 LEU A 203
GLU A 190
ARG A 194
LEU A 252
 None
 1.25A 5dxeA-1xknA:
undetectable		 5dxeA-1xknA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		4 / 7 GLU A  11
GLY A 157
GLY A  99
TYR A 290
 None
 0.99A 5e26A-1xknA:
undetectable
5e26B-1xknA:
undetectable		 5e26A-1xknA:
22.46
5e26B-1xknA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		3 / 3 PRO A 299
ILE A  55
SER A 285
 None
 0.75A 5fsaA-1xknA:
undetectable		 5fsaA-1xknA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		5 / 9 LEU A 168
THR A 170
LEU A 175
ILE A 189
LEU A 176
 None
 1.28A 5g48B-1xknA:
undetectable		 5g48B-1xknA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		5 / 12 LEU A 193
VAL A 218
GLY A 158
ALA A 159
LEU A 155
 None
 1.05A 5jw1A-1xknA:
undetectable		 5jw1A-1xknA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 1xkn PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE
(Chlorobaculum
tepidum) 		3 / 3 TYR A 301
LEU A 282
ASP A 278
 None
 0.85A 5zv2B-1xknA:
undetectable		 5zv2B-1xknA:
13.24