SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xkp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1xkp PUTATIVE
MEMBRANE-BOUND YOP
TARGETING PROTEIN
YOPN
(Yersinia
pestis) 		4 / 6 ASP A 242
LEU A 239
ILE A 180
GLU A 172
 None
 1.03A 1mt1A-1xkpA:
undetectable
1mt1F-1xkpA:
undetectable		 1mt1A-1xkpA:
13.97
1mt1F-1xkpA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1xkp PUTATIVE
MEMBRANE-BOUND YOP
TARGETING PROTEIN
YOPN
(Yersinia
pestis) 		4 / 6 ILE A 180
GLU A 172
ASP A 242
LEU A 239
 None
 0.95A 1mt1B-1xkpA:
undetectable
1mt1C-1xkpA:
undetectable		 1mt1B-1xkpA:
17.67
1mt1C-1xkpA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 1xkp CHAPERONE PROTEIN
SYCN
CHAPERONE PROTEIN
YSCB
(Yersinia
pestis) 		5 / 12 ARG C  96
SER C  41
LEU B 105
LEU B  80
PRO B  79
 None
 1.28A 1p33B-1xkpC:
undetectable		 1p33B-1xkpC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1xkp CHAPERONE PROTEIN
SYCN
(Yersinia
pestis) 		5 / 12 LEU B 103
LEU B 106
ALA B 109
LEU B 113
LEU B  15
 None
 1.15A 1s9pA-1xkpB:
undetectable		 1s9pA-1xkpB:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 1xkp CHAPERONE PROTEIN
SYCN
(Yersinia
pestis) 		5 / 12 LEU B  50
ALA B 109
GLN B 108
MET B  31
LEU B  15
 None
 1.36A 2oaxC-1xkpB:
undetectable		 2oaxC-1xkpB:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 1xkp CHAPERONE PROTEIN
SYCN
(Yersinia
pestis) 		5 / 12 LEU B  50
ALA B 109
GLN B 108
MET B  31
LEU B  15
 None
 1.35A 2oaxD-1xkpB:
undetectable		 2oaxD-1xkpB:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1xkp PUTATIVE
MEMBRANE-BOUND YOP
TARGETING PROTEIN
YOPN
(Yersinia
pestis) 		4 / 7 ASP A 242
LEU A 239
ILE A 180
GLU A 172
 None
 1.02A 2qqdA-1xkpA:
undetectable
2qqdE-1xkpA:
undetectable		 2qqdA-1xkpA:
13.97
2qqdE-1xkpA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1xkp CHAPERONE PROTEIN
SYCN
CHAPERONE PROTEIN
YSCB
PUTATIVE
MEMBRANE-BOUND YOP
TARGETING PROTEIN
YOPN
(Yersinia
pestis) 		5 / 12 ILE A  49
SER B  95
ARG B  81
LEU C  73
ALA C  76
 None
 1.11A 3dzyA-1xkpA:
undetectable		 3dzyA-1xkpA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 1xkp PUTATIVE
MEMBRANE-BOUND YOP
TARGETING PROTEIN
YOPN
(Yersinia
pestis) 		4 / 6 ARG A 186
ASP A 242
TYR A 202
PRO A 182
 None
None
None
MLY  A  93 ( 4.8A)
 1.29A 3jqaA-1xkpA:
undetectable		 3jqaA-1xkpA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 1xkp PUTATIVE
MEMBRANE-BOUND YOP
TARGETING PROTEIN
YOPN
(Yersinia
pestis) 		4 / 6 ARG A 186
ASP A 242
TYR A 202
PRO A 182
 None
None
None
MLY  A  93 ( 4.8A)
 1.33A 3jqaB-1xkpA:
undetectable		 3jqaB-1xkpA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 1xkp PUTATIVE
MEMBRANE-BOUND YOP
TARGETING PROTEIN
YOPN
(Yersinia
pestis) 		4 / 6 ARG A 186
ASP A 242
TYR A 202
PRO A 182
 None
None
None
MLY  A  93 ( 4.8A)
 1.28A 3jqaC-1xkpA:
undetectable		 3jqaC-1xkpA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 1xkp PUTATIVE
MEMBRANE-BOUND YOP
TARGETING PROTEIN
YOPN
(Yersinia
pestis) 		4 / 6 ARG A 186
ASP A 242
TYR A 202
PRO A 182
 None
None
None
MLY  A  93 ( 4.8A)
 1.29A 3jqaD-1xkpA:
undetectable		 3jqaD-1xkpA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KDM_H_TESH226_1
(IMMUNOGLOBULIN HEAVY
CHAIN
IMMUNOGLOBULIN LIGHT
CHAIN)		 1xkp PUTATIVE
MEMBRANE-BOUND YOP
TARGETING PROTEIN
YOPN
(Yersinia
pestis) 		5 / 9 SER A 133
ALA A 178
TYR A  90
TYR A 202
PRO A 182
 None
None
None
None
MLY  A  93 ( 4.8A)
 1.21A 3kdmH-1xkpA:
undetectable
3kdmL-1xkpA:
undetectable		 3kdmH-1xkpA:
22.43
3kdmL-1xkpA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 1xkp PUTATIVE
MEMBRANE-BOUND YOP
TARGETING PROTEIN
YOPN
(Yersinia
pestis) 		5 / 11 GLY A 177
ALA A 167
VAL A 175
GLN A  86
PRO A 182
 None
None
None
None
MLY  A  93 ( 4.8A)
 1.40A 4j4vA-1xkpA:
0.0		 4j4vA-1xkpA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 1xkp CHAPERONE PROTEIN
YSCB
PUTATIVE
MEMBRANE-BOUND YOP
TARGETING PROTEIN
YOPN
(Yersinia
pestis) 		3 / 3 LEU C  33
MET C  35
ASP A  82
 None
 0.77A 4j7xB-1xkpC:
undetectable		 4j7xB-1xkpC:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 1xkp CHAPERONE PROTEIN
SYCN
(Yersinia
pestis) 		5 / 12 LEU B  50
ALA B 109
GLN B 108
MET B  31
LEU B  15
 None
 1.15A 4ltwA-1xkpB:
undetectable		 4ltwA-1xkpB:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1xkp PUTATIVE
MEMBRANE-BOUND YOP
TARGETING PROTEIN
YOPN
(Yersinia
pestis) 		4 / 5 GLN A 135
SER A 133
ASP A 200
ASP A 218
 None
None
None
MLY  A 221 ( 4.6A)
 1.35A 4qtuB-1xkpA:
undetectable		 4qtuB-1xkpA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 1xkp CHAPERONE PROTEIN
SYCN
PUTATIVE
MEMBRANE-BOUND YOP
TARGETING PROTEIN
YOPN
(Yersinia
pestis) 		4 / 7 SER B  34
ARG A  35
PHE B 110
GLU A  37
 None
 1.46A 4xzkA-1xkpB:
undetectable		 4xzkA-1xkpB:
20.08