SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xkq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)
(Caenorhabditis
elegans) 		4 / 7 LEU A 169
ILE A 113
THR A 117
GLN A 109
 None
 1.23A 1kglA-1xkqA:
undetectable		 1kglA-1xkqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)
(Caenorhabditis
elegans) 		4 / 6 ILE A  11
VAL A   9
ILE A 251
ASP A 244
 None
 0.80A 1uwhB-1xkqA:
undetectable		 1uwhB-1xkqA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)
(Caenorhabditis
elegans) 		5 / 12 THR A 117
ASN A 121
GLY A  95
ALA A 124
THR A  68
 None
None
NDP  A1281 (-3.3A)
None
NDP  A1281 (-3.7A)
 1.39A 2axnA-1xkqA:
2.4		 2axnA-1xkqA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)
(Caenorhabditis
elegans) 		5 / 12 GLY A  13
ARG A  38
ARG A  42
ASP A  66
ASN A  93
 NDP  A1281 (-2.9A)
NDP  A1281 (-3.8A)
NDP  A1281 (-2.7A)
NDP  A1281 (-3.6A)
NDP  A1281 (-4.2A)
 1.05A 2bm9B-1xkqA:
5.3		 2bm9B-1xkqA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)
(Caenorhabditis
elegans) 		6 / 12 GLY A  13
ARG A  38
ARG A  42
ASP A  66
ASN A  93
ALA A  94
 NDP  A1281 (-2.9A)
NDP  A1281 (-3.8A)
NDP  A1281 (-2.7A)
NDP  A1281 (-3.6A)
NDP  A1281 (-4.2A)
NDP  A1281 (-3.7A)
 1.16A 2bm9E-1xkqA:
5.7		 2bm9E-1xkqA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)
(Caenorhabditis
elegans) 		5 / 12 GLY A  13
ARG A  38
ARG A  42
ASP A  66
ALA A  94
 NDP  A1281 (-2.9A)
NDP  A1281 (-3.8A)
NDP  A1281 (-2.7A)
NDP  A1281 (-3.6A)
NDP  A1281 (-3.7A)
 0.87A 2br4C-1xkqA:
5.4		 2br4C-1xkqA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)
(Caenorhabditis
elegans) 		5 / 12 GLY A  13
ARG A  38
ARG A  42
ASP A  66
ALA A  94
 NDP  A1281 (-2.9A)
NDP  A1281 (-3.8A)
NDP  A1281 (-2.7A)
NDP  A1281 (-3.6A)
NDP  A1281 (-3.7A)
 0.92A 2br4E-1xkqA:
5.4		 2br4E-1xkqA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)
(Caenorhabditis
elegans) 		5 / 12 GLY A  13
ARG A  38
ARG A  42
ASP A  66
ALA A  94
 NDP  A1281 (-2.9A)
NDP  A1281 (-3.8A)
NDP  A1281 (-2.7A)
NDP  A1281 (-3.6A)
NDP  A1281 (-3.7A)
 1.05A 2br4F-1xkqA:
5.4		 2br4F-1xkqA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)
(Caenorhabditis
elegans) 		5 / 10 ILE A 143
LEU A 180
GLY A 184
GLY A 141
ARG A 186
 None
 1.26A 2wd9C-1xkqA:
4.2		 2wd9C-1xkqA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)
(Caenorhabditis
elegans) 		5 / 12 THR A 117
ALA A 202
VAL A  67
VAL A 195
THR A 197
 None
NDP  A1281 ( 4.2A)
NDP  A1281 (-3.9A)
NDP  A1281 (-4.1A)
NDP  A1281 (-3.2A)
 1.25A 3dl9A-1xkqA:
undetectable		 3dl9A-1xkqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)
(Caenorhabditis
elegans) 		5 / 12 VAL A 125
ALA A 124
VAL A 132
MET A 128
THR A 129
 None
 1.17A 3dl9A-1xkqA:
undetectable		 3dl9A-1xkqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)
(Caenorhabditis
elegans) 		4 / 6 ILE A 164
ALA A 163
ALA A  97
THR A 117
 None
 1.01A 3mdrB-1xkqA:
undetectable		 3mdrB-1xkqA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)
(Caenorhabditis
elegans) 		4 / 6 THR A 200
GLY A 198
TYR A 214
GLY A 230
 None
NDP  A1281 (-3.4A)
None
None
 0.82A 4fjpA-1xkqA:
undetectable		 4fjpA-1xkqA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)
(Caenorhabditis
elegans) 		3 / 3 PHE A  26
VAL A  89
GLU A 142
 None
 0.78A 4fvqA-1xkqA:
undetectable		 4fvqA-1xkqA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)
(Caenorhabditis
elegans) 		5 / 11 ASP A 170
VAL A 257
ALA A 258
GLY A 152
SER A 147
 None
 1.30A 4mm9A-1xkqA:
undetectable		 4mm9A-1xkqA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)
(Caenorhabditis
elegans) 		5 / 9 ASP A 170
VAL A 257
ALA A 258
GLY A 152
SER A 147
 None
 1.32A 4mmeA-1xkqA:
undetectable		 4mmeA-1xkqA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)
(Caenorhabditis
elegans) 		5 / 9 ASP A 170
VAL A 257
ALA A 258
GLY A 152
SER A 147
 None
 1.33A 4mmeB-1xkqA:
undetectable		 4mmeB-1xkqA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)
(Caenorhabditis
elegans) 		5 / 9 ASP A 170
VAL A 257
ALA A 258
GLY A 152
SER A 147
 None
 1.31A 4mmfB-1xkqA:
undetectable		 4mmfB-1xkqA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)
(Caenorhabditis
elegans) 		4 / 7 LEU A  25
ILE A  35
ILE A  11
VAL A  33
 None
 0.78A 4ojbA-1xkqA:
undetectable		 4ojbA-1xkqA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)
(Caenorhabditis
elegans) 		5 / 12 ASN A  93
GLY A  95
LEU A 169
THR A  22
ILE A  11
 NDP  A1281 (-4.2A)
NDP  A1281 (-3.3A)
None
None
None
 1.33A 4p6xA-1xkqA:
undetectable		 4p6xA-1xkqA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)
(Caenorhabditis
elegans) 		5 / 12 ASN A  93
GLY A  95
LEU A 169
THR A  22
ILE A  11
 NDP  A1281 (-4.2A)
NDP  A1281 (-3.3A)
None
None
None
 1.31A 4p6xE-1xkqA:
undetectable		 4p6xE-1xkqA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)
(Caenorhabditis
elegans) 		4 / 6 PHE A 213
SER A 219
ALA A 218
HIS A 220
 None
 0.94A 5dzkB-1xkqA:
undetectable
5dzkP-1xkqA:
undetectable		 5dzkB-1xkqA:
22.41
5dzkP-1xkqA:
1.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)
(Caenorhabditis
elegans) 		4 / 7 PHE A 213
SER A 219
ALA A 218
HIS A 220
 None
 0.94A 5dzkD-1xkqA:
undetectable
5dzkR-1xkqA:
undetectable		 5dzkD-1xkqA:
22.41
5dzkR-1xkqA:
1.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)
(Caenorhabditis
elegans) 		4 / 6 PHE A 213
SER A 219
ALA A 218
HIS A 220
 None
 0.95A 5dzkg-1xkqA:
undetectable
5dzku-1xkqA:
undetectable		 5dzkg-1xkqA:
22.41
5dzku-1xkqA:
1.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1xkq SHORT-CHAIN
REDUCTASE FAMILY
MEMBER (5D234)
(Caenorhabditis
elegans) 		4 / 9 HIS A 135
ILE A  87
ILE A 239
LEU A 240
 None
 0.67A 5vkqB-1xkqA:
undetectable
5vkqC-1xkqA:
undetectable		 5vkqB-1xkqA:
10.87
5vkqC-1xkqA:
10.87