SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xks'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 1xks NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens) 		5 / 8 ALA A 178
ILE A 221
PRO A 234
ILE A 240
ILE A 184
 None
 1.47A 1hshD-1xksA:
undetectable		 1hshD-1xksA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1xks NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens) 		5 / 7 LEU A  96
GLY A  85
ILE A 128
PRO A  89
VAL A  92
 None
 1.44A 2aojB-1xksA:
undetectable		 2aojB-1xksA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 1xks NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens) 		5 / 11 SER A 292
SER A 291
GLN A 228
SER A 275
LEU A 274
 None
 1.08A 2xn5A-1xksA:
undetectable		 2xn5A-1xksA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 1xks NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens) 		3 / 3 ILE A 221
SER A 288
SER A 227
 None
 0.61A 3iltH-1xksA:
undetectable		 3iltH-1xksA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 1xks NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens) 		5 / 12 ILE A 403
ILE A 334
ILE A 368
ALA A 356
TYR A 370
 None
 1.23A 3ohtA-1xksA:
1.9
3ohtB-1xksA:
1.7		 3ohtA-1xksA:
23.65
3ohtB-1xksA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 1xks NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens) 		4 / 6 LEU A 245
LEU A 229
SER A 223
THR A 213
 None
 1.07A 4ikiB-1xksA:
undetectable		 4ikiB-1xksA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1xks NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens) 		3 / 3 SER A 162
ALA A 172
VAL A 173
 None
 0.62A 4x20C-1xksA:
undetectable		 4x20C-1xksA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 1xks NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens) 		5 / 12 VAL A 156
ILE A 124
LEU A 142
LEU A 190
VAL A 175
 None
 1.18A 5im2A-1xksA:
undetectable		 5im2A-1xksA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1xks NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens) 		5 / 12 ILE A 109
GLY A 455
VAL A 460
PHE A  84
ALA A 115
 None
 1.17A 5n0oA-1xksA:
undetectable		 5n0oA-1xksA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1xks NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens) 		5 / 12 ILE A 109
GLY A 455
VAL A 460
PHE A  84
ALA A 115
 None
 1.17A 5n0rA-1xksA:
undetectable		 5n0rA-1xksA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1xks NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens) 		5 / 12 ILE A 109
GLY A 455
VAL A 460
PHE A  84
ALA A 115
 None
 1.17A 5n0wA-1xksA:
undetectable		 5n0wA-1xksA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 1xks NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens) 		3 / 3 GLU A 198
ARG A 185
TYR A 196
 None
 0.54A 5trqB-1xksA:
0.0		 5trqB-1xksA:
21.55