SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xkt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1xkt FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A2479
LEU A2484
GLY A2451
TYR A2307
SER A2308
 None
 1.18A 1fduC-1xktA:
4.1		 1fduC-1xktA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		 1xkt FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 9 HIS A2498
LEU A2264
ALA A2261
LEU A2260
LEU A2246
 None
 1.08A 1hwiA-1xktA:
0.0		 1hwiA-1xktA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 1xkt FATTY ACID SYNTHASE
(Homo
sapiens) 		3 / 3 ASN A2463
PHE A2315
VAL A2467
 None
 0.68A 1kijA-1xktA:
undetectable		 1kijA-1xktA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 1xkt FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 6 LEU A2234
ASN A2235
LEU A2490
ILE A2494
 None
 0.97A 1z95A-1xktA:
undetectable		 1z95A-1xktA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 1xkt FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 7 ARG A2220
PHE A2375
ILE A2404
PHE A2371
 None
 1.15A 2q6hA-1xktA:
0.0		 2q6hA-1xktA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 1xkt FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 7 ARG A2220
PHE A2375
ILE A2404
PHE A2371
 None
 1.16A 2qb4A-1xktA:
undetectable		 2qb4A-1xktA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 1xkt FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 6 ARG A2220
PHE A2375
ILE A2404
PHE A2371
 None
 1.12A 2qeiA-1xktA:
undetectable		 2qeiA-1xktA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 1xkt FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 8 ILE A2404
LEU A2403
VAL A2383
GLN A2374
 None
 0.65A 2wd9B-1xktA:
3.3		 2wd9B-1xktA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1xkt FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 11 LEU A2334
ALA A2311
ALA A2314
LEU A2321
GLN A2322
 None
 1.21A 3bszE-1xktA:
undetectable		 3bszE-1xktA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1xkt FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 4 PHE A2418
TYR A2425
ILE A2405
LEU A2411
 None
 1.25A 3sudA-1xktA:
0.0		 3sudA-1xktA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1xkt FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 5 PHE A2418
TYR A2425
ILE A2405
LEU A2411
 None
 1.24A 3sueC-1xktA:
undetectable		 3sueC-1xktA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 1xkt FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 7 PRO A2301
GLN A2297
ARG A2242
VAL A2304
 None
 0.97A 4a3uB-1xktA:
undetectable		 4a3uB-1xktA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1xkt FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 9 ALA A2305
LEU A2260
LEU A2485
ILE A2477
 None
 0.87A 4xtaA-1xktA:
undetectable		 4xtaA-1xktA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1xkt FATTY ACID SYNTHASE
(Homo
sapiens) 		3 / 3 VAL A2472
SER A2340
MET A2317
 None
 0.93A 5ikqA-1xktA:
undetectable		 5ikqA-1xktA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1xkt FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 7 LEU A2416
VAL A2397
GLU A2394
ILE A2250
 None
 1.12A 5jh7C-1xktA:
3.8		 5jh7C-1xktA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 1xkt FATTY ACID SYNTHASE
(Homo
sapiens) 		5 / 12 PHE A2337
GLY A2339
VAL A2467
VAL A2313
ALA A2314
 None
 0.95A 5kocA-1xktA:
undetectable		 5kocA-1xktA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 1xkt FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 8 LEU A2427
TYR A2309
LEU A2279
ILE A2282
 None
 0.99A 5v0vA-1xktA:
2.5		 5v0vA-1xktA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA820_0
(GEPHYRIN)		 1xkt FATTY ACID SYNTHASE
(Homo
sapiens) 		4 / 5 GLU A2227
PRO A2226
THR A2274
GLN A2272
 None
 1.50A 6fgdA-1xktA:
2.4		 6fgdA-1xktA:
20.09