SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xkw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
4 / 8 ASN A 142
GLY A 391
THR A 434
GLN A 464
None
0.79A 1jr1B-1xkwA:
undetectable
1jr1B-1xkwA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
4 / 8 LEU A 536
GLY A 583
LEU A 538
PRO A  76
LDA  A2002 (-4.9A)
None
LDA  A2001 ( 4.5A)
None
0.94A 1ya4A-1xkwA:
undetectable
1ya4A-1xkwA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
6 / 11 ALA A 102
LEU A 133
LEU A 140
LEU A  99
LEU A 178
ARG A 180
None
1.13A 2ceoA-1xkwA:
undetectable
2ceoA-1xkwA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
5 / 10 ALA A 102
LEU A 133
LEU A 140
LEU A  99
ARG A 180
None
1.17A 2ceoB-1xkwA:
undetectable
2ceoB-1xkwA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
4 / 6 PHE A 231
ARG A 197
GLY A 707
ARG A 287
None
None
None
SO4  A3001 (-3.8A)
1.23A 2f7fA-1xkwA:
undetectable
2f7fA-1xkwA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
6 / 10 ALA A 102
LEU A 133
LEU A 140
LEU A  99
LEU A 178
ARG A 180
None
1.18A 2riwA-1xkwA:
undetectable
2riwB-1xkwA:
undetectable
2riwA-1xkwA:
17.79
2riwB-1xkwA:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
4 / 4 ARG A 228
GLY A 238
GLU A 226
SER A 330
None
1.27A 2xctS-1xkwA:
undetectable
2xctU-1xkwA:
undetectable
2xctS-1xkwA:
22.18
2xctU-1xkwA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
6 / 10 ALA A 102
LEU A 133
LEU A 140
LEU A  99
LEU A 178
ARG A 180
None
1.13A 2xn6A-1xkwA:
undetectable
2xn6B-1xkwA:
undetectable
2xn6A-1xkwA:
18.01
2xn6B-1xkwA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
6 / 10 ALA A 102
LEU A 133
LEU A 140
LEU A  99
LEU A 178
ARG A 180
None
1.16A 2xn7A-1xkwA:
undetectable
2xn7B-1xkwA:
undetectable
2xn7A-1xkwA:
18.01
2xn7B-1xkwA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
4 / 6 VAL A 500
GLN A  81
GLY A 482
ARG A 444
None
1.05A 3bjwE-1xkwA:
undetectable
3bjwE-1xkwA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
3 / 3 ASN A 713
ASN A 686
GLU A 708
None
0.93A 3kpdB-1xkwA:
undetectable
3kpdB-1xkwA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
5 / 11 THR A 393
THR A 433
THR A 434
THR A 435
SER A 360
None
1.22A 3mg0N-1xkwA:
undetectable
3mg0N-1xkwA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
5 / 12 GLN A 261
VAL A 176
GLY A 259
ALA A 323
ASP A 366
None
1.01A 3sueC-1xkwA:
undetectable
3sueC-1xkwA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
5 / 12 ARG A 363
GLN A 326
PHE A 131
GLU A 392
ASN A 142
None
1.22A 3t7sA-1xkwA:
undetectable
3t7sA-1xkwA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
4 / 8 GLY A 273
GLY A 336
LEU A 351
VAL A 408
None
0.92A 4fgzA-1xkwA:
undetectable
4fgzA-1xkwA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
5 / 11 THR A 393
THR A 433
THR A 434
THR A 435
SER A 360
None
1.19A 4qvyV-1xkwA:
undetectable
4qvyb-1xkwA:
0.0
4qvyV-1xkwA:
15.11
4qvyb-1xkwA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
5 / 11 THR A 393
THR A 433
THR A 434
THR A 435
SER A 360
None
1.20A 4qvyH-1xkwA:
undetectable
4qvyN-1xkwA:
0.0
4qvyH-1xkwA:
15.11
4qvyN-1xkwA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
5 / 12 ALA A  83
GLN A  81
LEU A  74
LEU A 165
LEU A 166
None
0.93A 4qzuC-1xkwA:
4.8
4qzuC-1xkwA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
3 / 3 TYR A 426
ARG A 331
LYS A 357
None
0.85A 4wq5B-1xkwA:
undetectable
4wq5B-1xkwA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
5 / 9 ALA A 102
LEU A 133
LEU A  99
LEU A 178
ARG A 180
None
1.09A 4x30A-1xkwA:
undetectable
4x30A-1xkwA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
5 / 10 VAL A 518
ILE A 545
LEU A 547
PRO A 551
LEU A 159
None
1.06A 5ienB-1xkwA:
1.2
5ienB-1xkwA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
5 / 11 THR A 393
THR A 433
THR A 434
THR A 435
SER A 360
None
1.20A 5l5fV-1xkwA:
0.1
5l5fb-1xkwA:
0.0
5l5fV-1xkwA:
15.11
5l5fb-1xkwA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
5 / 11 THR A 393
THR A 433
THR A 434
THR A 435
SER A 360
None
1.20A 5l5fH-1xkwA:
undetectable
5l5fN-1xkwA:
0.0
5l5fH-1xkwA:
15.11
5l5fN-1xkwA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
5 / 12 THR A 393
THR A 433
THR A 434
THR A 435
SER A 360
None
1.20A 5l5zV-1xkwA:
undetectable
5l5zb-1xkwA:
undetectable
5l5zV-1xkwA:
15.11
5l5zb-1xkwA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
5 / 12 THR A 393
THR A 433
THR A 434
THR A 435
SER A 360
None
1.19A 5l5zH-1xkwA:
undetectable
5l5zN-1xkwA:
undetectable
5l5zH-1xkwA:
15.11
5l5zN-1xkwA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
5 / 12 THR A 393
THR A 433
THR A 434
THR A 435
SER A 360
None
1.19A 5lf3b-1xkwA:
undetectable
5lf3b-1xkwA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
5 / 12 THR A 393
THR A 433
THR A 434
THR A 435
SER A 360
None
1.17A 5lf3N-1xkwA:
undetectable
5lf3N-1xkwA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
5 / 12 THR A 393
THR A 433
THR A 434
THR A 435
SER A 360
None
1.18A 5lf7V-1xkwA:
undetectable
5lf7b-1xkwA:
undetectable
5lf7V-1xkwA:
15.44
5lf7b-1xkwA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
5 / 12 THR A 393
THR A 433
THR A 434
THR A 435
SER A 360
None
1.18A 5lf7H-1xkwA:
undetectable
5lf7N-1xkwA:
undetectable
5lf7H-1xkwA:
15.44
5lf7N-1xkwA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
4 / 4 ARG A 333
SER A 267
ASP A 266
HIS A 264
None
1.49A 5zhmA-1xkwA:
undetectable
5zhmA-1xkwA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
5 / 12 ALA A 340
GLY A 346
ARG A 655
PRO A 700
TYR A 654
None
1.18A 5zvgA-1xkwA:
undetectable
5zvgA-1xkwA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
5 / 12 ALA A 340
GLY A 346
ARG A 655
PRO A 700
TYR A 654
None
1.17A 5zvgB-1xkwA:
undetectable
5zvgB-1xkwA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
5 / 10 LEU A  99
ALA A 102
TYR A 153
GLU A 324
VAL A  85
None
1.31A 6b89B-1xkwA:
undetectable
6b89B-1xkwA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
5 / 12 ILE A 675
THR A 680
THR A 191
VAL A 205
VAL A 207
None
1.18A 6bzoC-1xkwA:
0.0
6bzoC-1xkwA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_1
(STIE PROTEIN)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
4 / 5 THR A 387
ARG A 458
THR A 434
ASP A 465
None
1.19A 6ectA-1xkwA:
undetectable
6ectA-1xkwA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_1
(STIE PROTEIN)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
4 / 5 THR A 387
ARG A 458
THR A 434
ASP A 465
None
1.24A 6ecxA-1xkwA:
undetectable
6ecxA-1xkwA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa)
5 / 12 GLU A 381
GLY A 371
ASN A 368
GLN A 312
GLY A 319
None
0.83A 6gneB-1xkwA:
undetectable
6gneB-1xkwA:
21.95