SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xl3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1xl3 SECRETION CONTROL
PROTEIN
(Yersinia
pestis) 		3 / 3 SER A 129
GLU A 130
GLU A 131
 MLY  A 128 ( 4.0A)
None
None
 0.68A 1eqbD-1xl3A:
undetectable		 1eqbD-1xl3A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1xl3 SECRETION CONTROL
PROTEIN
(Yersinia
pestis) 		3 / 3 SER A 129
GLU A 130
GLU A 131
 MLY  A 128 ( 4.0A)
None
None
 0.68A 1eqbB-1xl3A:
undetectable		 1eqbB-1xl3A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1xl3 SECRETION CONTROL
PROTEIN
(Yersinia
pestis) 		4 / 6 ASP A 242
LEU A 239
ILE A 180
GLU A 172
 None
 0.98A 1mt1A-1xl3A:
undetectable
1mt1F-1xl3A:
undetectable		 1mt1A-1xl3A:
14.68
1mt1F-1xl3A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_B_AG2B7001_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1xl3 SECRETION CONTROL
PROTEIN
(Yersinia
pestis) 		4 / 6 ILE A 180
GLU A 172
ASP A 242
LEU A 239
 None
 0.91A 1mt1B-1xl3A:
undetectable
1mt1C-1xl3A:
undetectable		 1mt1B-1xl3A:
17.06
1mt1C-1xl3A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 1xl3 PROTEIN TYPE A
SECRETION CONTROL
PROTEIN
(Yersinia
pestis) 		4 / 7 GLY C  10
GLN A 220
ILE C  12
VAL C  13
 None
 0.93A 1rxcC-1xl3C:
undetectable		 1rxcC-1xl3C:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 1xl3 PROTEIN TYPE A
SECRETION CONTROL
PROTEIN
(Yersinia
pestis) 		4 / 8 GLY C  10
GLN A 220
ILE C  12
VAL C  13
 None
 0.91A 1rxcI-1xl3C:
undetectable		 1rxcI-1xl3C:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 1xl3 PROTEIN TYPE A
SECRETION CONTROL
PROTEIN
(Yersinia
pestis) 		4 / 8 GLY C  10
GLN A 220
ILE C  12
VAL C  13
 None
 0.92A 1rxcK-1xl3C:
undetectable		 1rxcK-1xl3C:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 1xl3 PROTEIN TYPE A
SECRETION CONTROL
PROTEIN
(Yersinia
pestis) 		5 / 12 VAL A 271
SER A 270
VAL C  16
LEU C  70
LEU C  48
 None
None
None
MLY  C  49 ( 4.7A)
MLY  C  49 ( 3.8A)
 1.22A 2hc4A-1xl3A:
0.0		 2hc4A-1xl3A:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1xl3 SECRETION CONTROL
PROTEIN
(Yersinia
pestis) 		4 / 7 ASP A 242
LEU A 239
ILE A 180
GLU A 172
 None
 1.02A 2qqdA-1xl3A:
undetectable
2qqdE-1xl3A:
undetectable		 2qqdA-1xl3A:
15.68
2qqdE-1xl3A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 1xl3 SECRETION CONTROL
PROTEIN
(Yersinia
pestis) 		3 / 3 SER A 188
ARG A 186
GLN A 189
 None
 0.96A 2xnrA-1xl3A:
undetectable		 2xnrA-1xl3A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1xl3 SECRETION CONTROL
PROTEIN
(Yersinia
pestis) 		3 / 3 GLY A 208
ILE A 257
VAL A 258
 None
MLY  A 254 ( 4.0A)
MLY  A 254 ( 4.1A)
 0.41A 3nv6A-1xl3A:
undetectable		 3nv6A-1xl3A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1xl3 PROTEIN TYPE A
(Yersinia
pestis) 		4 / 8 PHE C  60
VAL C  16
MET C   9
ILE C  12
 None
 1.04A 4a97D-1xl3C:
4.4		 4a97D-1xl3C:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1xl3 PROTEIN TYPE A
(Yersinia
pestis) 		4 / 8 PHE C  60
VAL C  16
MET C   9
ILE C  12
 None
 1.06A 4a97G-1xl3C:
undetectable		 4a97G-1xl3C:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1xl3 PROTEIN TYPE A
(Yersinia
pestis) 		4 / 8 PHE C  60
VAL C  16
MET C   9
ILE C  12
 None
 1.07A 4a97I-1xl3C:
4.4		 4a97I-1xl3C:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 1xl3 SECRETION CONTROL
PROTEIN
(Yersinia
pestis) 		5 / 11 GLY A 177
ALA A 167
VAL A 175
GLN A  86
PRO A 182
 None
 1.42A 4j4vA-1xl3A:
2.1		 4j4vA-1xl3A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_B_SVRB301_1
(NUCLEOCAPSID PROTEIN)		 1xl3 SECRETION CONTROL
PROTEIN
(Yersinia
pestis) 		5 / 10 GLY A 177
ALA A 167
VAL A 175
GLN A  86
PRO A 182
 None
 1.42A 4j4vB-1xl3A:
undetectable		 4j4vB-1xl3A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1xl3 SECRETION CONTROL
PROTEIN
(Yersinia
pestis) 		4 / 5 GLN A 135
SER A 133
ASP A 200
ASP A 218
 None
None
None
MLY  A 221 ( 3.6A)
 1.27A 4qtuB-1xl3A:
undetectable		 4qtuB-1xl3A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1xl3 SECRETION CONTROL
PROTEIN
(Yersinia
pestis) 		4 / 5 GLN A 135
SER A 133
ASP A 200
ASP A 218
 None
None
None
MLY  A 221 ( 3.6A)
 1.21A 4qtuD-1xl3A:
undetectable		 4qtuD-1xl3A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1xl3 PROTEIN TYPE A
SECRETION CONTROL
PROTEIN
(Yersinia
pestis) 		3 / 3 PHE A 223
ASP A 227
LEU C   5
 None
 0.63A 5uhbC-1xl3A:
undetectable		 5uhbC-1xl3A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1xl3 PROTEIN TYPE A
SECRETION CONTROL
PROTEIN
(Yersinia
pestis) 		3 / 3 PHE A 223
ASP A 227
LEU C   5
 None
 0.65A 5uhcC-1xl3A:
undetectable		 5uhcC-1xl3A:
12.77