SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xl8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		4 / 4 THR A 241
LEU A 240
VAL A 380
LEU A 377
 None
 1.02A 1fbmB-1xl8A:
undetectable		 1fbmB-1xl8A:
5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		4 / 8 LEU A  28
VAL A  55
LEU A 524
ALA A  62
 None
 0.87A 1fiqC-1xl8A:
undetectable		 1fiqC-1xl8A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		4 / 8 ARG A 245
SER A  97
ASN A 102
ASP A 308
 None
 1.24A 1hwiB-1xl8A:
3.6		 1hwiB-1xl8A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		4 / 7 ARG A 245
SER A  97
ASN A 102
ASP A 308
 None
 1.24A 1hwiC-1xl8A:
3.4		 1hwiC-1xl8A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		4 / 7 ARG A 245
SER A  97
ASN A 102
ASP A 308
 None
 1.24A 1hwiD-1xl8A:
3.4		 1hwiD-1xl8A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		4 / 8 ARG A 245
SER A  97
ASN A 102
ASP A 308
 None
 1.26A 1hwkA-1xl8A:
3.4		 1hwkA-1xl8A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		4 / 8 ARG A 245
SER A  97
ASN A 102
ASP A 308
 None
 1.26A 1hwkD-1xl8A:
3.2		 1hwkD-1xl8A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		3 / 3 VAL A  88
ALA A  89
HIS A 327
 None
None
152  A 613 (-4.3A)
 0.60A 1q23C-1xl8A:
9.9		 1q23C-1xl8A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		3 / 3 VAL A  88
ALA A  89
HIS A 327
 None
None
152  A 613 (-4.3A)
 0.70A 1q23H-1xl8A:
10.0		 1q23H-1xl8A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		3 / 3 VAL A  88
ALA A  89
HIS A 327
 None
None
152  A 613 (-4.3A)
 0.59A 1q23G-1xl8A:
9.8		 1q23G-1xl8A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		3 / 3 VAL A  88
ALA A  89
HIS A 327
 None
None
152  A 613 (-4.3A)
 0.62A 1q23L-1xl8A:
9.5		 1q23L-1xl8A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		3 / 3 VAL A  88
ALA A  89
HIS A 327
 None
None
152  A 613 (-4.3A)
 0.68A 1q23J-1xl8A:
9.6		 1q23J-1xl8A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		4 / 8 ILE A 192
LEU A 273
PHE A 274
LEU A 211
 None
 0.87A 1v55N-1xl8A:
undetectable
1v55W-1xl8A:
undetectable		 1v55N-1xl8A:
19.90
1v55W-1xl8A:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		3 / 3 TRP A  85
THR A 441
TYR A 439
 152  A 613 (-4.7A)
152  A 613 (-2.8A)
152  A 613 (-4.3A)
 1.23A 2a3aA-1xl8A:
undetectable		 2a3aA-1xl8A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		3 / 3 TRP A  85
THR A 441
TYR A 439
 152  A 613 (-4.7A)
152  A 613 (-2.8A)
152  A 613 (-4.3A)
 1.23A 2a3aB-1xl8A:
undetectable		 2a3aB-1xl8A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		3 / 3 TRP A  85
THR A 441
TYR A 439
 152  A 613 (-4.7A)
152  A 613 (-2.8A)
152  A 613 (-4.3A)
 1.23A 2a3bA-1xl8A:
undetectable		 2a3bA-1xl8A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		3 / 3 ASP A 308
ILE A  95
VAL A 555
 None
 0.69A 2avvD-1xl8A:
undetectable		 2avvD-1xl8A:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		4 / 8 ILE A 192
LEU A 273
PHE A 274
LEU A 211
 None
 0.87A 2einA-1xl8A:
undetectable
2einJ-1xl8A:
undetectable		 2einA-1xl8A:
19.90
2einJ-1xl8A:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		5 / 10 PHE A 294
TYR A 290
ALA A 577
MET A 335
VAL A 336
 None
 1.20A 2wuzA-1xl8A:
undetectable		 2wuzA-1xl8A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		5 / 10 PHE A 294
TYR A 290
ALA A 577
MET A 335
VAL A 336
 None
 1.19A 2wuzB-1xl8A:
undetectable		 2wuzB-1xl8A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		4 / 8 GLY A 322
ILE A 338
ASN A 132
MET A 128
 None
 0.92A 2x0pA-1xl8A:
1.4		 2x0pA-1xl8A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		5 / 12 GLY A 564
GLY A 562
LEU A 592
VAL A 555
PHE A 566
 None
 1.01A 2zulA-1xl8A:
undetectable		 2zulA-1xl8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		4 / 8 ILE A 192
LEU A 273
PHE A 274
LEU A 211
 None
 0.79A 3abkA-1xl8A:
2.3
3abkJ-1xl8A:
undetectable		 3abkA-1xl8A:
19.90
3abkJ-1xl8A:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		4 / 8 ILE A 192
LEU A 273
PHE A 274
LEU A 211
 None
 0.84A 3abmN-1xl8A:
2.4
3abmW-1xl8A:
undetectable		 3abmN-1xl8A:
19.90
3abmW-1xl8A:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		4 / 8 ILE A 192
LEU A 273
PHE A 274
LEU A 211
 None
 0.82A 3asoN-1xl8A:
2.2
3asoW-1xl8A:
undetectable		 3asoN-1xl8A:
19.90
3asoW-1xl8A:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		3 / 3 LYS A 148
LYS A  11
VAL A 146
 None
 0.79A 3brfA-1xl8A:
undetectable		 3brfA-1xl8A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		5 / 12 GLY A 564
GLY A 562
LEU A 592
VAL A 555
PHE A 566
 None
 1.01A 3dmhA-1xl8A:
undetectable		 3dmhA-1xl8A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		5 / 12 SER A 399
VAL A 576
ILE A 596
PHE A 600
HIS A 601
 None
 1.23A 4c49D-1xl8A:
undetectable		 4c49D-1xl8A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		4 / 6 GLY A 322
MET A 128
ASN A 132
ILE A 320
 None
 0.93A 4fglD-1xl8A:
undetectable		 4fglD-1xl8A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		3 / 3 LYS A 515
LEU A 511
ALA A 514
 None
 0.74A 4ikiA-1xl8A:
undetectable		 4ikiA-1xl8A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		4 / 7 PRO A  41
VAL A 460
ALA A 462
TYR A 428
 None
 1.15A 4lb2A-1xl8A:
undetectable		 4lb2A-1xl8A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		3 / 3 LEU A 507
ARG A 505
MET A 443
 None
 0.94A 4m11C-1xl8A:
undetectable		 4m11C-1xl8A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NSB_A_AINA402_1
(CHITINASE-3-LIKE
PROTEIN 1)		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		4 / 7 THR A 241
TRP A 248
ARG A 245
TRP A 306
 None
 1.29A 4nsbA-1xl8A:
undetectable		 4nsbA-1xl8A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		4 / 6 THR A 452
ALA A 442
THR A 441
VAL A 455
 152  A 613 (-2.7A)
None
152  A 613 (-2.8A)
None
 0.97A 5ecoA-1xl8A:
2.3		 5ecoA-1xl8A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		5 / 12 GLY A 562
SER A 579
CYH A 437
PHE A 539
THR A 543
 None
 1.09A 5yf0A-1xl8A:
0.8		 5yf0A-1xl8A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		4 / 8 ILE A 192
LEU A 273
PHE A 274
LEU A 211
 None
 0.83A 5zcpN-1xl8A:
undetectable
5zcpW-1xl8A:
undetectable		 5zcpN-1xl8A:
19.90
5zcpW-1xl8A:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E
(Mus
musculus) 		3 / 3 LEU A 133
ASN A 312
LEU A 162
 None
 0.55A 6exiA-1xl8A:
undetectable		 6exiA-1xl8A:
11.23