SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xly'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1xly SHE2P
(Saccharomyces
cerevisiae) 		3 / 3 THR A 109
LEU A 113
LEU A 121
 None
 0.48A 1mz9C-1xlyA:
undetectable		 1mz9C-1xlyA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 1xly SHE2P
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 227
ILE A 144
ASN A 114
PHE A 110
 None
 1.11A 2jc9A-1xlyA:
undetectable		 2jc9A-1xlyA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 1xly SHE2P
(Saccharomyces
cerevisiae) 		4 / 6 PHE A  92
PHE A 208
THR A  13
VAL A  17
 None
 1.16A 3lb3A-1xlyA:
undetectable		 3lb3A-1xlyA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 1xly SHE2P
(Saccharomyces
cerevisiae) 		4 / 6 PHE A  92
PHE A 208
THR A  13
VAL A  17
 None
 1.13A 3lb3B-1xlyA:
undetectable		 3lb3B-1xlyA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 1xly SHE2P
(Saccharomyces
cerevisiae) 		4 / 7 ASN A 114
LEU A 136
LEU A 226
PHE A 110
 None
 1.23A 3nk2X-1xlyA:
undetectable		 3nk2X-1xlyA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1xly SHE2P
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 223
LEU A  35
ASN A  66
 None
 0.77A 4otwA-1xlyA:
undetectable		 4otwA-1xlyA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 1xly SHE2P
(Saccharomyces
cerevisiae) 		5 / 10 GLN A 122
LEU A 121
LEU A 117
LEU A  35
LEU A 136
 None
 1.08A 4yiaA-1xlyA:
0.3		 4yiaA-1xlyA:
22.60