SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xm5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1xm5 HYPOTHETICAL UPF0054
PROTEIN YBEY
(Escherichia
coli) 		3 / 3 SER A1022
GLU A1021
GLU A1020
 None
 0.68A 1eqbD-1xm5A:
undetectable		 1eqbD-1xm5A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1xm5 HYPOTHETICAL UPF0054
PROTEIN YBEY
(Escherichia
coli) 		3 / 3 SER A1022
GLU A1021
GLU A1020
 None
 0.69A 1eqbB-1xm5A:
undetectable		 1eqbB-1xm5A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1xm5 HYPOTHETICAL UPF0054
PROTEIN YBEY
(Escherichia
coli) 		3 / 3 HIS A1124
HIS A1118
HIS A1114
 NI  A5001 (-3.3A)
NI  A5001 (-3.4A)
NI  A5001 (-3.4A)
 0.72A 2einN-1xm5A:
undetectable		 2einN-1xm5A:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 1xm5 HYPOTHETICAL UPF0054
PROTEIN YBEY
(Escherichia
coli) 		3 / 3 HIS A1114
HIS A1118
HIS A1124
 NI  A5001 (-3.4A)
NI  A5001 (-3.4A)
NI  A5001 (-3.3A)
 0.38A 2ozrF-1xm5A:
5.8		 2ozrF-1xm5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S38_A_CUA803_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1xm5 HYPOTHETICAL UPF0054
PROTEIN YBEY
(Escherichia
coli) 		3 / 3 HIS A1124
HIS A1118
HIS A1114
 NI  A5001 (-3.3A)
NI  A5001 (-3.4A)
NI  A5001 (-3.4A)
 0.77A 3s38A-1xm5A:
undetectable		 3s38A-1xm5A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 1xm5 HYPOTHETICAL UPF0054
PROTEIN YBEY
(Escherichia
coli) 		4 / 7 MET A1141
LEU A1142
ASP A1148
HIS A1110
 None
 1.12A 4aq7A-1xm5A:
undetectable		 4aq7A-1xm5A:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 1xm5 HYPOTHETICAL UPF0054
PROTEIN YBEY
(Escherichia
coli) 		5 / 7 HIS A1124
HIS A1118
LEU A1117
VAL A1067
SER A1069
 NI  A5001 (-3.3A)
NI  A5001 (-3.4A)
None
None
None
 1.42A 5m8rA-1xm5A:
undetectable		 5m8rA-1xm5A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 1xm5 HYPOTHETICAL UPF0054
PROTEIN YBEY
(Escherichia
coli) 		5 / 8 HIS A1124
HIS A1118
LEU A1117
VAL A1067
SER A1069
 NI  A5001 (-3.3A)
NI  A5001 (-3.4A)
None
None
None
 1.43A 5m8rB-1xm5A:
undetectable		 5m8rB-1xm5A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 1xm5 HYPOTHETICAL UPF0054
PROTEIN YBEY
(Escherichia
coli) 		5 / 8 HIS A1124
HIS A1118
LEU A1117
VAL A1067
SER A1069
 NI  A5001 (-3.3A)
NI  A5001 (-3.4A)
None
None
None
 1.41A 5m8rD-1xm5A:
undetectable		 5m8rD-1xm5A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 1xm5 HYPOTHETICAL UPF0054
PROTEIN YBEY
(Escherichia
coli) 		3 / 3 HIS A1124
HIS A1118
HIS A1114
 NI  A5001 (-3.3A)
NI  A5001 (-3.4A)
NI  A5001 (-3.4A)
 0.69A 5x1fN-1xm5A:
undetectable		 5x1fN-1xm5A:
12.82