SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xm9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9U_A_CPFA5002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1xm9 PLAKOPHILIN 1
(Homo
sapiens) 		4 / 6 PHE A 404
ARG A 312
ASN A 356
GLN A 349
 None
 1.25A 1t9uA-1xm9A:
0.0		 1t9uA-1xm9A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1xm9 PLAKOPHILIN 1
(Homo
sapiens) 		4 / 8 LEU A 433
ALA A 527
LEU A 522
ALA A 550
 None
 0.90A 2vcvF-1xm9A:
1.4		 2vcvF-1xm9A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1xm9 PLAKOPHILIN 1
(Homo
sapiens) 		4 / 6 LEU A 465
ALA A 550
LEU A 458
ALA A 527
 None
 0.99A 2vcvK-1xm9A:
3.5		 2vcvK-1xm9A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1xm9 PLAKOPHILIN 1
(Homo
sapiens) 		5 / 8 VAL A 619
LEU A 623
VAL A 644
ARG A 645
LEU A 686
 None
 1.32A 3kp6A-1xm9A:
undetectable
3kp6B-1xm9A:
undetectable		 3kp6A-1xm9A:
15.50
3kp6B-1xm9A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 1xm9 PLAKOPHILIN 1
(Homo
sapiens) 		5 / 12 LEU A 311
LEU A 314
VAL A 315
SER A 318
VAL A 293
 None
 1.02A 3m7rA-1xm9A:
undetectable		 3m7rA-1xm9A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 1xm9 PLAKOPHILIN 1
(Homo
sapiens) 		5 / 12 VAL A 619
LEU A 623
VAL A 591
GLY A 594
ALA A 595
 None
 1.06A 3nt1A-1xm9A:
0.0		 3nt1A-1xm9A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 1xm9 PLAKOPHILIN 1
(Homo
sapiens) 		5 / 12 VAL A 619
LEU A 623
VAL A 591
GLY A 594
ALA A 595
 None
 1.06A 3nt1B-1xm9A:
undetectable		 3nt1B-1xm9A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 1xm9 PLAKOPHILIN 1
(Homo
sapiens) 		5 / 12 GLY A 570
GLY A 575
ILE A 579
LEU A 607
VAL A 610
 None
 1.12A 3o7wA-1xm9A:
undetectable		 3o7wA-1xm9A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 1xm9 PLAKOPHILIN 1
(Homo
sapiens) 		5 / 11 VAL A 619
LEU A 623
VAL A 591
GLY A 594
ALA A 595
 None
 1.10A 3pghB-1xm9A:
undetectable		 3pghB-1xm9A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 1xm9 PLAKOPHILIN 1
(Homo
sapiens) 		5 / 12 VAL A 619
LEU A 623
VAL A 591
GLY A 594
ALA A 595
 None
 1.09A 3pghD-1xm9A:
undetectable		 3pghD-1xm9A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1xm9 PLAKOPHILIN 1
(Homo
sapiens) 		5 / 12 VAL A 619
LEU A 623
VAL A 591
GLY A 594
ALA A 595
 None
 1.04A 3rr3A-1xm9A:
0.6		 3rr3A-1xm9A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1xm9 PLAKOPHILIN 1
(Homo
sapiens) 		5 / 12 VAL A 619
LEU A 623
VAL A 591
GLY A 594
ALA A 595
 None
 1.03A 3rr3B-1xm9A:
undetectable		 3rr3B-1xm9A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1xm9 PLAKOPHILIN 1
(Homo
sapiens) 		5 / 12 VAL A 619
LEU A 623
VAL A 591
GLY A 594
ALA A 595
 None
 1.04A 3rr3C-1xm9A:
0.2		 3rr3C-1xm9A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1xm9 PLAKOPHILIN 1
(Homo
sapiens) 		5 / 12 VAL A 619
LEU A 623
VAL A 591
GLY A 594
ALA A 595
 None
 1.04A 3rr3D-1xm9A:
0.0		 3rr3D-1xm9A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1xm9 PLAKOPHILIN 1
(Homo
sapiens) 		5 / 12 GLU A 277
ASP A 276
ILE A 247
LEU A 286
SER A 318
 None
 1.48A 4djfB-1xm9A:
undetectable		 4djfB-1xm9A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 1xm9 PLAKOPHILIN 1
(Homo
sapiens) 		5 / 10 LEU A 296
LEU A 311
ALA A 308
LEU A 357
LEU A 350
 None
 1.11A 4p65A-1xm9A:
undetectable
4p65B-1xm9A:
undetectable
4p65F-1xm9A:
undetectable
4p65H-1xm9A:
undetectable		 4p65A-1xm9A:
3.86
4p65B-1xm9A:
6.67
4p65F-1xm9A:
6.67
4p65H-1xm9A:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 1xm9 PLAKOPHILIN 1
(Homo
sapiens) 		5 / 11 LEU A 296
LEU A 311
ALA A 308
LEU A 350
LEU A 357
 None
 1.12A 4p65C-1xm9A:
undetectable
4p65D-1xm9A:
undetectable
4p65J-1xm9A:
undetectable
4p65L-1xm9A:
undetectable		 4p65C-1xm9A:
3.86
4p65D-1xm9A:
6.67
4p65J-1xm9A:
6.67
4p65L-1xm9A:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 1xm9 PLAKOPHILIN 1
(Homo
sapiens) 		5 / 12 LEU A 375
GLY A 330
GLU A 366
LEU A 367
CYH A 409
 None
 1.26A 4x61A-1xm9A:
undetectable		 4x61A-1xm9A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1xm9 PLAKOPHILIN 1
(Homo
sapiens) 		3 / 3 ALA A 550
ASN A 553
LEU A 554
 None
 0.50A 5i1nC-1xm9A:
undetectable		 5i1nC-1xm9A:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 1xm9 PLAKOPHILIN 1
(Homo
sapiens) 		3 / 3 VAL A 283
GLN A 270
CYH A 273
 None
 0.43A 5icxA-1xm9A:
undetectable
5icxE-1xm9A:
undetectable		 5icxA-1xm9A:
19.29
5icxE-1xm9A:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 1xm9 PLAKOPHILIN 1
(Homo
sapiens) 		3 / 3 VAL A 283
GLN A 270
CYH A 273
 None
 0.58A 5icxC-1xm9A:
undetectable
5icxF-1xm9A:
undetectable		 5icxC-1xm9A:
19.29
5icxF-1xm9A:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1xm9 PLAKOPHILIN 1
(Homo
sapiens) 		5 / 12 VAL A 619
LEU A 623
VAL A 591
GLY A 594
ALA A 595
 None
 1.04A 5jvzA-1xm9A:
undetectable		 5jvzA-1xm9A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 1xm9 PLAKOPHILIN 1
(Homo
sapiens) 		5 / 10 ILE A 430
LEU A 433
ILE A 381
ALA A 376
ILE A 380
 None
 1.04A 5mvmD-1xm9A:
1.7
5mvmE-1xm9A:
1.7		 5mvmD-1xm9A:
10.07
5mvmE-1xm9A:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1xm9 PLAKOPHILIN 1
(Homo
sapiens) 		5 / 7 GLY A 549
LEU A 551
ILE A 579
GLY A 594
LEU A 582
 None
 1.13A 5vkqA-1xm9A:
1.4
5vkqB-1xm9A:
3.6		 5vkqA-1xm9A:
14.05
5vkqB-1xm9A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1xm9 PLAKOPHILIN 1
(Homo
sapiens) 		5 / 8 GLY A 549
LEU A 551
ILE A 579
GLY A 594
LEU A 582
 None
 1.14A 5vkqB-1xm9A:
3.6
5vkqC-1xm9A:
1.8		 5vkqB-1xm9A:
14.05
5vkqC-1xm9A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 1xm9 PLAKOPHILIN 1
(Homo
sapiens) 		4 / 7 LEU A 623
LEU A 637
ALA A 682
ALA A 683
 None
 0.86A 6a7jA-1xm9A:
undetectable		 6a7jA-1xm9A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1xm9 PLAKOPHILIN 1
(Homo
sapiens) 		4 / 7 VAL A 590
ILE A 636
GLY A 612
ALA A 580
 None
 0.80A 6hd6B-1xm9A:
undetectable		 6hd6B-1xm9A:
9.61