SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xmb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		4 / 5 LYS A  43
LEU A  39
ALA A  42
LEU A  38
 None
 1.05A 1eta1-1xmbA:
undetectable		 1eta1-1xmbA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		4 / 5 LYS A  43
LEU A  39
ALA A  42
LEU A  38
 None
 0.97A 1eta2-1xmbA:
undetectable		 1eta2-1xmbA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		4 / 4 LYS A  43
LEU A  39
ALA A  42
LEU A  38
 None
 1.15A 1f86B-1xmbA:
undetectable		 1f86B-1xmbA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		5 / 9 GLY A 195
HIS A 380
ALA A 374
HIS A 197
ILE A 193
 None
 1.49A 1gtfI-1xmbA:
undetectable
1gtfJ-1xmbA:
undetectable		 1gtfI-1xmbA:
10.98
1gtfJ-1xmbA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		5 / 9 SER A 396
GLY A 141
HIS A 142
HIS A 139
ILE A 403
 None
 1.43A 1gtnG-1xmbA:
undetectable
1gtnH-1xmbA:
undetectable		 1gtnG-1xmbA:
10.98
1gtnH-1xmbA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		4 / 8 GLU A 173
GLN A 169
HIS A 135
TYR A 401
 None
 1.08A 1nx9B-1xmbA:
2.9		 1nx9B-1xmbA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		4 / 8 GLU A 173
GLN A 169
HIS A 135
TYR A 401
 None
 1.11A 1nx9C-1xmbA:
2.7		 1nx9C-1xmbA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		4 / 8 GLU A 173
GLN A 169
HIS A 135
TYR A 401
 None
 1.10A 1nx9D-1xmbA:
2.7		 1nx9D-1xmbA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		4 / 5 SER A 382
SER A 209
VAL A 349
PHE A 358
 None
 1.08A 1oipA-1xmbA:
undetectable		 1oipA-1xmbA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		5 / 8 ALA A 115
ASP A 114
ILE A 118
GLY A 138
ILE A 403
 None
 1.40A 1sh9A-1xmbA:
undetectable		 1sh9A-1xmbA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		5 / 12 HIS A 380
SER A 382
ILE A 196
LEU A 109
ALA A 150
 None
 1.11A 1tlsA-1xmbA:
0.0		 1tlsA-1xmbA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		5 / 12 HIS A 380
SER A 382
ILE A 196
LEU A 109
ALA A 150
 None
 1.06A 1tlsB-1xmbA:
undetectable		 1tlsB-1xmbA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		5 / 12 HIS A 380
SER A 382
ILE A 196
LEU A 109
ALA A 150
 None
 1.13A 1tsnA-1xmbA:
undetectable		 1tsnA-1xmbA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_A_TRPA81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		5 / 9 GLY A 195
HIS A 380
ALA A 374
HIS A 197
ILE A 193
 None
 1.49A 1utdA-1xmbA:
undetectable
1utdB-1xmbA:
undetectable		 1utdA-1xmbA:
10.98
1utdB-1xmbA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		4 / 7 GLY A 385
PHE A 204
ASP A 388
TYR A 393
 None
 1.12A 2aouB-1xmbA:
undetectable		 2aouB-1xmbA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		4 / 6 LYS A  43
LEU A  39
ALA A  42
LEU A  38
 None
 1.04A 2roxB-1xmbA:
undetectable		 2roxB-1xmbA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		5 / 12 PHE A 295
LEU A 198
ASP A 112
GLU A 173
GLU A 172
 None
 1.39A 3aocC-1xmbA:
6.4		 3aocC-1xmbA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		5 / 12 ILE A 225
ILE A 288
VAL A 270
GLY A 290
LEU A 324
 None
 1.06A 3em0B-1xmbA:
0.0		 3em0B-1xmbA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		5 / 12 GLY A 162
LEU A 160
ILE A  99
ALA A 419
LEU A 166
 None
 1.05A 3gwvA-1xmbA:
undetectable		 3gwvA-1xmbA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		3 / 3 SER A 367
ASP A 112
ASP A 140
 None
 0.92A 3uj7A-1xmbA:
undetectable		 3uj7A-1xmbA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		3 / 3 LYS A 129
GLU A  60
TRP A 124
 None
 1.16A 3v4tH-1xmbA:
1.7		 3v4tH-1xmbA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		3 / 3 TYR A 401
ASP A 140
ASP A 114
 None
 0.88A 4a6eA-1xmbA:
undetectable		 4a6eA-1xmbA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		4 / 7 ILE A  54
HIS A 154
VAL A 164
PHE A 168
 None
 1.02A 4a97H-1xmbA:
undetectable		 4a97H-1xmbA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		4 / 6 LYS A  43
LEU A  39
ALA A  42
LEU A  38
 None
 1.00A 4ikiB-1xmbA:
undetectable		 4ikiB-1xmbA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		3 / 3 VAL A 364
ALA A 362
PHE A 295
 None
 0.85A 4olbA-1xmbA:
2.6		 4olbA-1xmbA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		5 / 11 HIS A 139
GLU A 172
GLU A 173
GLY A 366
HIS A 397
 None
 0.86A 4pqaA-1xmbA:
28.3		 4pqaA-1xmbA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		5 / 11 ASP A 406
GLU A 405
ARG A  56
MET A  51
THR A 144
 None
 1.27A 4urnB-1xmbA:
undetectable		 4urnB-1xmbA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		3 / 3 TYR A 342
ARG A 350
LYS A 346
 None
 1.44A 4wq5B-1xmbA:
undetectable		 4wq5B-1xmbA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		3 / 3 VAL A 364
ALA A 362
PHE A 295
 None
 0.82A 4z4iA-1xmbA:
undetectable		 4z4iA-1xmbA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		4 / 5 LYS A  43
LEU A  39
ALA A  42
LEU A  38
 None
 1.07A 5cr1A-1xmbA:
undetectable		 5cr1A-1xmbA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		5 / 10 SER A 396
GLY A 141
HIS A 142
HIS A 139
ILE A 403
 None
 1.44A 5eeuG-1xmbA:
undetectable
5eeuH-1xmbA:
undetectable		 5eeuG-1xmbA:
10.98
5eeuH-1xmbA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		5 / 10 SER A 396
GLY A 141
HIS A 142
HIS A 139
ILE A 403
 None
 1.44A 5eevG-1xmbA:
undetectable
5eevH-1xmbA:
undetectable		 5eevG-1xmbA:
10.98
5eevH-1xmbA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		5 / 10 SER A 396
GLY A 141
HIS A 142
HIS A 139
ILE A 403
 None
 1.44A 5eewG-1xmbA:
undetectable
5eewH-1xmbA:
undetectable		 5eewG-1xmbA:
10.98
5eewH-1xmbA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		5 / 10 SER A 396
GLY A 141
HIS A 142
HIS A 139
ILE A 403
 None
 1.44A 5eexG-1xmbA:
undetectable
5eexH-1xmbA:
undetectable		 5eexG-1xmbA:
10.98
5eexH-1xmbA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		5 / 10 GLY A 141
HIS A 142
HIS A 139
ILE A 403
SER A 396
 None
 1.44A 5eexA-1xmbA:
undetectable
5eexK-1xmbA:
undetectable		 5eexA-1xmbA:
10.98
5eexK-1xmbA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		5 / 10 SER A 396
GLY A 141
HIS A 142
HIS A 139
ILE A 403
 None
 1.44A 5eeyG-1xmbA:
undetectable
5eeyH-1xmbA:
undetectable		 5eeyG-1xmbA:
10.98
5eeyH-1xmbA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		5 / 10 SER A 396
GLY A 141
HIS A 142
HIS A 139
ILE A 403
 None
 1.44A 5eezG-1xmbA:
undetectable
5eezH-1xmbA:
undetectable		 5eezG-1xmbA:
10.98
5eezH-1xmbA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		5 / 9 GLY A 195
HIS A 380
ALA A 374
HIS A 197
ILE A 193
 None
 1.49A 5eezJ-1xmbA:
undetectable
5eezK-1xmbA:
undetectable		 5eezJ-1xmbA:
10.98
5eezK-1xmbA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		5 / 10 SER A 396
GLY A 141
HIS A 142
HIS A 139
ILE A 403
 None
 1.44A 5ef0G-1xmbA:
undetectable
5ef0H-1xmbA:
undetectable		 5ef0G-1xmbA:
10.98
5ef0H-1xmbA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		5 / 9 GLY A 195
HIS A 380
ALA A 374
HIS A 197
ILE A 193
 None
 1.49A 5ef0J-1xmbA:
undetectable
5ef0K-1xmbA:
undetectable		 5ef0J-1xmbA:
10.98
5ef0K-1xmbA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		5 / 10 GLY A 141
HIS A 142
HIS A 139
ILE A 403
SER A 396
 None
 1.44A 5ef0A-1xmbA:
undetectable
5ef0K-1xmbA:
undetectable		 5ef0A-1xmbA:
10.98
5ef0K-1xmbA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		5 / 10 SER A 396
GLY A 141
HIS A 142
HIS A 139
ILE A 403
 None
 1.44A 5ef1G-1xmbA:
undetectable
5ef1H-1xmbA:
undetectable		 5ef1G-1xmbA:
10.98
5ef1H-1xmbA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		5 / 9 GLY A 195
HIS A 380
ALA A 374
HIS A 197
ILE A 193
 None
 1.49A 5ef1J-1xmbA:
undetectable
5ef1K-1xmbA:
undetectable		 5ef1J-1xmbA:
10.98
5ef1K-1xmbA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		5 / 10 SER A 396
GLY A 141
HIS A 142
HIS A 139
ILE A 403
 None
 1.44A 5ef2G-1xmbA:
undetectable
5ef2H-1xmbA:
undetectable		 5ef2G-1xmbA:
10.98
5ef2H-1xmbA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		5 / 9 GLY A 195
HIS A 380
ALA A 374
HIS A 197
ILE A 193
 None
 1.49A 5ef2J-1xmbA:
undetectable
5ef2K-1xmbA:
undetectable		 5ef2J-1xmbA:
10.98
5ef2K-1xmbA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		5 / 10 SER A 396
GLY A 141
HIS A 142
HIS A 139
ILE A 403
 None
 1.44A 5ef3G-1xmbA:
undetectable
5ef3H-1xmbA:
undetectable		 5ef3G-1xmbA:
10.98
5ef3H-1xmbA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		5 / 9 GLY A 195
HIS A 380
ALA A 374
HIS A 197
ILE A 193
 None
 1.49A 5ef3J-1xmbA:
undetectable
5ef3K-1xmbA:
undetectable		 5ef3J-1xmbA:
10.98
5ef3K-1xmbA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		3 / 3 VAL A 364
ALA A 362
PHE A 295
 None
 0.85A 5js1A-1xmbA:
2.4		 5js1A-1xmbA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		4 / 6 VAL A 364
LEU A 198
SER A 199
ILE A 403
 None
 0.92A 5jw1A-1xmbA:
undetectable		 5jw1A-1xmbA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		5 / 8 VAL A 270
ILE A 309
LEU A 252
ILE A 248
ILE A 225
 None
 1.31A 5numA-1xmbA:
undetectable		 5numA-1xmbA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FZB_B_SRYB301_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		5 / 12 ASP A 114
GLU A 173
LEU A 383
HIS A 142
ILE A 196
 None
 1.46A 6fzbB-1xmbA:
0.4		 6fzbB-1xmbA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		4 / 4 LYS A  43
LEU A  39
ALA A  42
LEU A  38
 None
 1.09A 6gnrA-1xmbA:
0.0		 6gnrA-1xmbA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2
(Arabidopsis
thaliana) 		4 / 4 LYS A  43
LEU A  39
ALA A  42
LEU A  38
 None
 1.07A 6gnrB-1xmbA:
undetectable		 6gnrB-1xmbA:
16.11