SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xmj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1xmj CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 6 ALA A 559
TYR A 517
ILE A 556
ILE A 521
 None
 1.24A 2dcfA-1xmjA:
undetectable		 2dcfA-1xmjA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 1xmj CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 7 THR A 438
PRO A 439
VAL A 440
GLU A 621
 None
None
ATP  A   1 (-4.8A)
None
 0.92A 2v2gA-1xmjA:
undetectable
2v2gB-1xmjA:
undetectable		 2v2gA-1xmjA:
21.73
2v2gB-1xmjA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 1xmj CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 7 THR A 438
PRO A 439
VAL A 440
GLU A 621
 None
None
ATP  A   1 (-4.8A)
None
 0.95A 2v2gA-1xmjA:
undetectable
2v2gB-1xmjA:
undetectable		 2v2gA-1xmjA:
21.73
2v2gB-1xmjA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 1xmj CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 7 THR A 438
PRO A 439
VAL A 440
GLU A 621
 None
None
ATP  A   1 (-4.8A)
None
 0.92A 2v2gC-1xmjA:
undetectable
2v2gD-1xmjA:
undetectable		 2v2gC-1xmjA:
21.73
2v2gD-1xmjA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 1xmj CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 7 THR A 438
PRO A 439
VAL A 440
GLU A 621
 None
None
ATP  A   1 (-4.8A)
None
 0.94A 2v2gC-1xmjA:
undetectable
2v2gD-1xmjA:
undetectable		 2v2gC-1xmjA:
21.73
2v2gD-1xmjA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 1xmj CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 8 THR A 438
PRO A 439
VAL A 440
GLU A 621
 None
None
ATP  A   1 (-4.8A)
None
 0.90A 2v32A-1xmjA:
undetectable
2v32B-1xmjA:
undetectable		 2v32A-1xmjA:
21.73
2v32B-1xmjA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 1xmj CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 8 THR A 438
PRO A 439
VAL A 440
GLU A 621
 None
None
ATP  A   1 (-4.8A)
None
 0.95A 2v32A-1xmjA:
undetectable
2v32B-1xmjA:
undetectable		 2v32A-1xmjA:
21.73
2v32B-1xmjA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 1xmj CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 8 THR A 438
PRO A 439
VAL A 440
GLU A 621
 None
None
ATP  A   1 (-4.8A)
None
 0.92A 2v32C-1xmjA:
undetectable
2v32D-1xmjA:
undetectable		 2v32C-1xmjA:
21.73
2v32D-1xmjA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 1xmj CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 8 THR A 438
PRO A 439
VAL A 440
GLU A 621
 None
None
ATP  A   1 (-4.8A)
None
 0.93A 2v32C-1xmjA:
undetectable
2v32D-1xmjA:
undetectable		 2v32C-1xmjA:
21.73
2v32D-1xmjA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 1xmj CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 8 THR A 438
PRO A 439
VAL A 440
GLU A 621
 None
None
ATP  A   1 (-4.8A)
None
 0.92A 2v41C-1xmjA:
undetectable
2v41D-1xmjA:
undetectable		 2v41C-1xmjA:
21.73
2v41D-1xmjA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 1xmj CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 8 THR A 438
PRO A 439
VAL A 440
GLU A 621
 None
None
ATP  A   1 (-4.8A)
None
 1.01A 2v41C-1xmjA:
undetectable
2v41D-1xmjA:
undetectable		 2v41C-1xmjA:
21.73
2v41D-1xmjA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 1xmj CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 7 THR A 438
PRO A 439
VAL A 440
GLU A 621
 None
None
ATP  A   1 (-4.8A)
None
 0.90A 2v41E-1xmjA:
undetectable
2v41F-1xmjA:
undetectable		 2v41E-1xmjA:
21.73
2v41F-1xmjA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 1xmj CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 7 THR A 438
PRO A 439
VAL A 440
GLU A 621
 None
None
ATP  A   1 (-4.8A)
None
 0.91A 2v41E-1xmjA:
undetectable
2v41F-1xmjA:
undetectable		 2v41E-1xmjA:
21.73
2v41F-1xmjA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)		 1xmj CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 8 THR A 438
PRO A 439
VAL A 440
GLU A 621
 None
None
ATP  A   1 (-4.8A)
None
 1.02A 2v41G-1xmjA:
undetectable
2v41H-1xmjA:
undetectable		 2v41G-1xmjA:
21.73
2v41H-1xmjA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 1xmj CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		5 / 11 LEU A 548
SER A 549
ILE A 556
PHE A 575
ASP A 579
 None
 1.40A 3ko0E-1xmjA:
undetectable
3ko0F-1xmjA:
undetectable
3ko0G-1xmjA:
undetectable
3ko0H-1xmjA:
undetectable		 3ko0E-1xmjA:
17.19
3ko0F-1xmjA:
17.19
3ko0G-1xmjA:
17.19
3ko0H-1xmjA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 1xmj CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		5 / 11 ASP A 579
LEU A 548
SER A 549
ILE A 556
PHE A 575
 None
 1.35A 3ko0Q-1xmjA:
undetectable
3ko0R-1xmjA:
undetectable
3ko0S-1xmjA:
undetectable
3ko0T-1xmjA:
undetectable		 3ko0Q-1xmjA:
17.19
3ko0R-1xmjA:
17.19
3ko0S-1xmjA:
17.19
3ko0T-1xmjA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 1xmj CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 7 LEU A 570
ALA A 566
ASP A 565
VAL A 562
 None
 0.91A 4eyrA-1xmjA:
undetectable		 4eyrA-1xmjA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1xmj CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		5 / 12 ASP A 565
LEU A 526
ALA A 561
SER A 489
GLY A 509
 None
 1.25A 5syeB-1xmjA:
undetectable		 5syeB-1xmjA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWV_A_BEZA202_0
(ARA H 8 ALLERGEN)		 1xmj CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR
(Homo
sapiens) 		4 / 4 PHE A 640
ASP A 639
LEU A 644
LYS A 643
 None
 1.46A 6awvA-1xmjA:
undetectable		 6awvA-1xmjA:
21.99