SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xmp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1xmp PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bacillus
anthracis) 		5 / 8 THR A  17
GLY A 117
GLY A  66
SER A  98
GLY A  64
 None
 1.38A 1jhqA-1xmpA:
4.5		 1jhqA-1xmpA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 1xmp PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bacillus
anthracis) 		5 / 12 GLY A  64
GLY A  85
ILE A  61
VAL A  88
ALA A  69
 None
 1.04A 1sg9B-1xmpA:
4.0		 1sg9B-1xmpA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 1xmp PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bacillus
anthracis) 		5 / 12 GLY A  66
ALA A  65
ASP A  14
GLY A 117
ILE A 116
 None
 1.05A 2b7zA-1xmpA:
undetectable		 2b7zA-1xmpA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 1xmp PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bacillus
anthracis) 		5 / 10 ALA A 124
VAL A   5
VAL A   7
ILE A  61
VAL A  60
 None
 1.03A 2nnjA-1xmpA:
undetectable		 2nnjA-1xmpA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1xmp PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bacillus
anthracis) 		5 / 12 GLY A 125
SER A 121
GLY A 120
ILE A  30
ALA A 128
 None
 0.97A 3douA-1xmpA:
undetectable		 3douA-1xmpA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 1xmp PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bacillus
anthracis) 		5 / 10 GLY A  66
ALA A  65
ASP A  14
GLY A 117
ILE A 116
 None
 1.07A 3el9B-1xmpA:
undetectable		 3el9B-1xmpA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_2
(PROTEASE)		 1xmp PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bacillus
anthracis) 		5 / 9 GLY A  66
ALA A  65
ASP A  14
GLY A 117
ILE A 116
 None
 1.07A 3gguB-1xmpA:
undetectable		 3gguB-1xmpA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 1xmp PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bacillus
anthracis) 		3 / 3 ASP A  44
PHE A  47
SER A  38
 None
 1.00A 3i5uB-1xmpA:
3.6		 3i5uB-1xmpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1xmp PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bacillus
anthracis) 		3 / 3 GLY A 125
ILE A  61
VAL A  60
 None
 0.46A 3nv6A-1xmpA:
undetectable		 3nv6A-1xmpA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 1xmp PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bacillus
anthracis) 		5 / 9 GLY A  66
ALA A  65
ASP A  14
GLY A 117
ILE A 116
 None
 0.94A 3ogpA-1xmpA:
undetectable		 3ogpA-1xmpA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1xmp PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bacillus
anthracis) 		5 / 12 ALA A 129
GLY A 133
SER A 134
LEU A 143
ALA A 124
 None
 1.35A 3ou7C-1xmpA:
undetectable		 3ou7C-1xmpA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)		 1xmp PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bacillus
anthracis) 		5 / 8 GLY A  66
ALA A  65
ASP A  14
GLY A 117
ILE A 116
 None
 1.14A 3so9A-1xmpA:
undetectable		 3so9A-1xmpA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 1xmp PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bacillus
anthracis) 		5 / 9 GLY A  66
ALA A  65
ASP A  14
GLY A 117
ILE A 116
 None
 1.05A 3u7sB-1xmpA:
undetectable		 3u7sB-1xmpA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 1xmp PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bacillus
anthracis) 		5 / 12 GLY A  66
ALA A  65
ASP A  14
GLY A 117
ILE A 116
 None
 1.01A 3ucbA-1xmpA:
undetectable		 3ucbA-1xmpA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1xmp PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bacillus
anthracis) 		5 / 12 LEU A  25
VAL A  86
ILE A 131
LEU A 127
VAL A 114
 None
 1.11A 3w68B-1xmpA:
undetectable		 3w68B-1xmpA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1xmp PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bacillus
anthracis) 		5 / 12 GLY A 120
SER A 121
MET A  18
GLY A  67
SER A  98
 None
 1.07A 5gwxA-1xmpA:
2.7		 5gwxA-1xmpA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1xmp PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bacillus
anthracis) 		5 / 12 GLY A 120
SER A 121
MET A  18
GLY A  67
SER A  98
 None
 1.03A 5hikA-1xmpA:
2.7		 5hikA-1xmpA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1xmp PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bacillus
anthracis) 		3 / 3 LYS A  78
LEU A  58
ILE A   8
 None
 0.77A 5kc4A-1xmpA:
undetectable		 5kc4A-1xmpA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1xmp PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
(Bacillus
anthracis) 		4 / 4 LEU A  96
GLY A  95
SER A  98
SER A 101
 None
 1.31A 5uunB-1xmpA:
undetectable		 5uunB-1xmpA:
20.21