SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xmx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1xmx HYPOTHETICAL PROTEIN
VC1899
(Vibrio
cholerae) 		4 / 8 SER A  45
HIS A  28
SER A  54
TYR A  41
 None
 1.29A 1eqbA-1xmxA:
undetectable
1eqbB-1xmxA:
undetectable		 1eqbA-1xmxA:
20.13
1eqbB-1xmxA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1xmx HYPOTHETICAL PROTEIN
VC1899
(Vibrio
cholerae) 		4 / 8 TYR A  41
SER A  45
HIS A  28
SER A  54
 None
 1.29A 1eqbA-1xmxA:
undetectable
1eqbB-1xmxA:
undetectable		 1eqbA-1xmxA:
20.13
1eqbB-1xmxA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1xmx HYPOTHETICAL PROTEIN
VC1899
(Vibrio
cholerae) 		4 / 8 SER A  45
HIS A  28
SER A  54
TYR A  41
 None
 1.30A 1eqbC-1xmxA:
undetectable
1eqbD-1xmxA:
undetectable		 1eqbC-1xmxA:
20.13
1eqbD-1xmxA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1xmx HYPOTHETICAL PROTEIN
VC1899
(Vibrio
cholerae) 		4 / 8 TYR A  41
SER A  45
HIS A  28
SER A  54
 None
 1.30A 1eqbC-1xmxA:
undetectable
1eqbD-1xmxA:
undetectable		 1eqbC-1xmxA:
20.13
1eqbD-1xmxA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 1xmx HYPOTHETICAL PROTEIN
VC1899
(Vibrio
cholerae) 		4 / 5 ASP A  11
VAL A  13
ASP A 328
GLN A 334
 None
 1.15A 1n2xB-1xmxA:
4.6		 1n2xB-1xmxA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 1xmx HYPOTHETICAL PROTEIN
VC1899
(Vibrio
cholerae) 		5 / 12 LEU A 189
ASN A 190
LEU A 192
ALA A 193
THR A 309
 None
 1.36A 2aa6A-1xmxA:
undetectable		 2aa6A-1xmxA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1xmx HYPOTHETICAL PROTEIN
VC1899
(Vibrio
cholerae) 		3 / 3 ILE A  73
PHE A  89
HIS A  97
 None
 0.59A 3h0aA-1xmxA:
undetectable		 3h0aA-1xmxA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 1xmx HYPOTHETICAL PROTEIN
VC1899
(Vibrio
cholerae) 		4 / 8 SER A  92
LEU A  44
ASP A   9
ASP A  11
 None
 0.92A 3n2oC-1xmxA:
undetectable
3n2oD-1xmxA:
undetectable		 3n2oC-1xmxA:
20.57
3n2oD-1xmxA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 1xmx HYPOTHETICAL PROTEIN
VC1899
(Vibrio
cholerae) 		4 / 8 TRP A 175
ARG A 174
LEU A 171
GLU A 225
 None
 1.37A 3zmdA-1xmxA:
2.7
3zmdB-1xmxA:
2.8		 3zmdA-1xmxA:
20.41
3zmdB-1xmxA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 1xmx HYPOTHETICAL PROTEIN
VC1899
(Vibrio
cholerae) 		3 / 3 TYR A 145
ASP A  11
ASP A 328
 None
 0.58A 4a6eA-1xmxA:
2.8		 4a6eA-1xmxA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1xmx HYPOTHETICAL PROTEIN
VC1899
(Vibrio
cholerae) 		4 / 7 PHE A 106
TYR A 109
VAL A  87
ILE A   3
 None
 0.97A 4a97E-1xmxA:
undetectable		 4a97E-1xmxA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1xmx HYPOTHETICAL PROTEIN
VC1899
(Vibrio
cholerae) 		4 / 8 PHE A 106
TYR A 109
VAL A  87
ILE A   3
 None
 1.02A 4a97C-1xmxA:
undetectable		 4a97C-1xmxA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1xmx HYPOTHETICAL PROTEIN
VC1899
(Vibrio
cholerae) 		4 / 8 PHE A 106
TYR A 109
VAL A  87
ILE A   3
 None
 0.96A 4a97D-1xmxA:
undetectable		 4a97D-1xmxA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1xmx HYPOTHETICAL PROTEIN
VC1899
(Vibrio
cholerae) 		4 / 8 PHE A 106
TYR A 109
VAL A  87
ILE A   3
 None
 0.93A 4a97G-1xmxA:
undetectable		 4a97G-1xmxA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1xmx HYPOTHETICAL PROTEIN
VC1899
(Vibrio
cholerae) 		4 / 7 PHE A 106
TYR A 109
VAL A  87
ILE A   3
 None
 0.96A 4a97H-1xmxA:
undetectable		 4a97H-1xmxA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1xmx HYPOTHETICAL PROTEIN
VC1899
(Vibrio
cholerae) 		4 / 8 PHE A 106
TYR A 109
VAL A  87
ILE A   3
 None
 0.92A 4a97I-1xmxA:
undetectable		 4a97I-1xmxA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 1xmx HYPOTHETICAL PROTEIN
VC1899
(Vibrio
cholerae) 		6 / 12 GLY A   6
ILE A  32
ILE A  30
LEU A  44
HIS A   4
ILE A   3
 None
None
None
None
GOL  A 401 (-4.1A)
None
 1.48A 4azvA-1xmxA:
3.9		 4azvA-1xmxA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 1xmx HYPOTHETICAL PROTEIN
VC1899
(Vibrio
cholerae) 		5 / 11 THR A 309
PHE A 342
LEU A 252
VAL A 256
LEU A 366
 None
 1.15A 4g1bB-1xmxA:
6.2		 4g1bB-1xmxA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 1xmx HYPOTHETICAL PROTEIN
VC1899
(Vibrio
cholerae) 		5 / 9 THR A 309
PHE A 342
LEU A 252
VAL A 256
LEU A 366
 None
 1.18A 4g1bC-1xmxA:
5.2		 4g1bC-1xmxA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 1xmx HYPOTHETICAL PROTEIN
VC1899
(Vibrio
cholerae) 		4 / 8 GLY A 249
THR A 254
LEU A 171
PHE A 246
 None
FMT  A 406 (-4.3A)
None
None
 1.19A 4m5mA-1xmxA:
undetectable		 4m5mA-1xmxA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1xmx HYPOTHETICAL PROTEIN
VC1899
(Vibrio
cholerae) 		4 / 5 GLY A 249
LEU A 275
LEU A 168
LEU A 366
 None
None
FMT  A 406 (-4.2A)
None
 0.80A 4o8fA-1xmxA:
undetectable		 4o8fA-1xmxA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 1xmx HYPOTHETICAL PROTEIN
VC1899
(Vibrio
cholerae) 		5 / 12 LEU A  99
GLY A  94
LEU A  15
VAL A   5
ILE A  40
 None
 1.36A 4okbA-1xmxA:
undetectable		 4okbA-1xmxA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1xmx HYPOTHETICAL PROTEIN
VC1899
(Vibrio
cholerae) 		5 / 12 GLU A 250
LEU A 186
LEU A 164
GLY A 172
ALA A 176
 None
 1.09A 4retC-1xmxA:
5.4		 4retC-1xmxA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1xmx HYPOTHETICAL PROTEIN
VC1899
(Vibrio
cholerae) 		4 / 8 LEU A  80
PHE A 106
ILE A  73
GLY A   6
 None
 0.89A 5eseA-1xmxA:
undetectable		 5eseA-1xmxA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 1xmx HYPOTHETICAL PROTEIN
VC1899
(Vibrio
cholerae) 		5 / 12 PHE A 149
GLY A 331
VAL A 298
GLY A 150
ALA A 143
 None
 0.95A 6c2mB-1xmxA:
undetectable		 6c2mB-1xmxA:
10.65