SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xn4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 1xn4 RIBONUCLEASE MAR1
(Leishmania
major) 		4 / 7 GLY A  63
PRO A  61
ASP A  19
HIS A  59
 None
 0.93A 1gxsA-1xn4A:
2.1
1gxsB-1xn4A:
undetectable		 1gxsA-1xn4A:
19.17
1gxsB-1xn4A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 1xn4 RIBONUCLEASE MAR1
(Leishmania
major) 		5 / 10 ALA A  14
ILE A 113
LEU A 134
TYR A  54
THR A  13
 None
 1.37A 1tdrB-1xn4A:
undetectable		 1tdrB-1xn4A:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1xn4 RIBONUCLEASE MAR1
(Leishmania
major) 		4 / 7 GLY A 106
PHE A 105
PRO A 130
ASP A 132
 None
 1.01A 2aouB-1xn4A:
3.8		 2aouB-1xn4A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1xn4 RIBONUCLEASE MAR1
(Leishmania
major) 		3 / 3 SER A  86
GLN A 115
PHE A  85
 None
 0.70A 3g4lC-1xn4A:
0.0		 3g4lC-1xn4A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1xn4 RIBONUCLEASE MAR1
(Leishmania
major) 		5 / 8 VAL A 117
LEU A 120
ILE A 113
VAL A 104
LEU A  16
 None
 1.15A 3kp6A-1xn4A:
undetectable
3kp6B-1xn4A:
undetectable		 3kp6A-1xn4A:
25.49
3kp6B-1xn4A:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1xn4 RIBONUCLEASE MAR1
(Leishmania
major) 		4 / 5 VAL A  37
PHE A  31
ILE A 107
PHE A  24
 None
 1.10A 3owxB-1xn4A:
5.4		 3owxB-1xn4A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 1xn4 RIBONUCLEASE MAR1
(Leishmania
major) 		4 / 7 VAL A 127
LEU A 129
ALA A 102
LEU A 121
 None
 0.68A 5jq7A-1xn4A:
0.0		 5jq7A-1xn4A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 1xn4 RIBONUCLEASE MAR1
(Leishmania
major) 		4 / 5 VAL A 117
LEU A 134
VAL A  37
LEU A  20
 None
 0.99A 6bqgA-1xn4A:
undetectable		 6bqgA-1xn4A:
15.62