SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xng'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Helicobacter
pylori) 		5 / 11 LEU A  44
GLY A  42
LEU A  74
LEU A 167
LEU A 171
 None
 1.10A 1mx1B-1xngA:
undetectable		 1mx1B-1xngA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Helicobacter
pylori) 		4 / 7 LEU A 233
LEU A 207
LEU A 196
GLY A 197
 None
 0.81A 1n13D-1xngA:
undetectable
1n13E-1xngA:
undetectable		 1n13D-1xngA:
18.87
1n13E-1xngA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Helicobacter
pylori) 		4 / 8 SER A 136
THR A 162
PHE A 160
ASP A 209
 None
 1.21A 1p7lC-1xngA:
undetectable		 1p7lC-1xngA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Helicobacter
pylori) 		4 / 8 SER A 136
THR A 162
PHE A 160
ASP A 209
 None
 1.19A 1p7lD-1xngA:
undetectable		 1p7lD-1xngA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Helicobacter
pylori) 		4 / 8 SER A 136
THR A 162
PHE A 160
ASP A 209
 None
 1.17A 1rg9A-1xngA:
undetectable		 1rg9A-1xngA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Helicobacter
pylori) 		4 / 8 SER A 136
THR A 162
PHE A 160
ASP A 209
 None
 1.17A 1rg9B-1xngA:
undetectable		 1rg9B-1xngA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Helicobacter
pylori) 		4 / 8 SER A 136
THR A 162
PHE A 160
ASP A 209
 None
 1.21A 1rg9C-1xngA:
undetectable		 1rg9C-1xngA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Helicobacter
pylori) 		4 / 8 SER A 136
THR A 162
PHE A 160
ASP A 209
 None
 1.19A 1rg9D-1xngA:
undetectable		 1rg9D-1xngA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Helicobacter
pylori) 		5 / 10 LEU A  36
ALA A 168
LEU A 171
PRO A 174
LEU A  74
 ATP  A 303 (-4.2A)
None
None
None
None
 0.84A 1yi4A-1xngA:
undetectable		 1yi4A-1xngA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Helicobacter
pylori) 		4 / 6 SER A 102
ALA A 101
THR A 104
ASN A 108
 None
None
DND  A 301 (-4.0A)
DND  A 301 (-3.2A)
 1.04A 1yvpB-1xngA:
undetectable		 1yvpB-1xngA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Helicobacter
pylori) 		4 / 4 PRO A  65
ASP A 185
ASP A 192
ASP A  70
 None
None
DND  A 301 ( 4.2A)
None
 1.48A 2nyuA-1xngA:
2.5		 2nyuA-1xngA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Helicobacter
pylori) 		5 / 9 ILE A 241
ILE A 219
GLU A 211
LEU A 207
LYS A 135
 None
 1.08A 3f78A-1xngA:
undetectable		 3f78A-1xngA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		 1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Helicobacter
pylori) 		5 / 9 ILE A 241
ILE A 219
GLU A 211
LEU A 207
LYS A 135
 None
 1.07A 3f78B-1xngA:
2.2		 3f78B-1xngA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Helicobacter
pylori) 		4 / 5 LYS A  77
LEU A  44
TYR A  82
ARG A 169
 None
 1.33A 4bkjB-1xngA:
undetectable		 4bkjB-1xngA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Helicobacter
pylori) 		4 / 4 ASN A 154
GLY A 157
ASP A 195
ASP A  37
 None
None
None
ATP  A 303 (-3.9A)
 1.24A 4n49A-1xngA:
undetectable		 4n49A-1xngA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Helicobacter
pylori) 		4 / 6 GLY A  34
ASP A 185
ASP A  37
ASP A  70
 None
None
ATP  A 303 (-3.9A)
None
 0.85A 4uckB-1xngA:
undetectable		 4uckB-1xngA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1007_1
(SERUM ALBUMIN)		 1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Helicobacter
pylori) 		5 / 9 ARG A 170
LEU A   8
LEU A  44
ILE A 156
ALA A 168
 None
 1.48A 4z69A-1xngA:
2.4		 4z69A-1xngA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Helicobacter
pylori) 		4 / 6 LEU A 224
PRO A 205
PHE A 160
GLU A 163
 None
 1.28A 5b8iA-1xngA:
undetectable		 5b8iA-1xngA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Helicobacter
pylori) 		4 / 8 SER A 136
THR A 162
PHE A 160
ASP A 209
 None
 1.15A 5t8sB-1xngA:
undetectable		 5t8sB-1xngA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Helicobacter
pylori) 		5 / 12 GLY A  35
ASP A 148
LEU A 149
CYH A 151
ASP A  37
 ATP  A 303 (-3.2A)
DND  A 301 (-3.2A)
None
None
ATP  A 303 (-3.9A)
 1.18A 5yniA-1xngA:
undetectable		 5yniA-1xngA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE
(Helicobacter
pylori) 		5 / 12 GLY A  35
ASP A 148
LEU A 149
CYH A 151
ASP A  37
 ATP  A 303 (-3.2A)
DND  A 301 (-3.2A)
None
None
ATP  A 303 (-3.9A)
 1.17A 5ynmA-1xngA:
undetectable		 5ynmA-1xngA:
23.56