SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xnj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		4 / 8 GLU B 108
ARG B 111
ARG B 112
LEU B  99
 None
 0.87A 1cmaA-1xnjB:
undetectable
1cmaB-1xnjB:
undetectable		 1cmaA-1xnjB:
11.02
1cmaB-1xnjB:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		5 / 12 ALA B 312
ASP B 316
ARG B 334
ILE B 259
THR B 313
 None
 1.12A 1d1gA-1xnjB:
undetectable		 1d1gA-1xnjB:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		5 / 12 ALA B 312
ASP B 316
ARG B 334
ILE B 259
THR B 313
 None
 1.10A 1d1gB-1xnjB:
undetectable		 1d1gB-1xnjB:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		3 / 4 VAL B 387
TRP B 274
TRP B 389
 None
 1.38A 1gmkC-1xnjB:
undetectable
1gmkD-1xnjB:
undetectable		 1gmkC-1xnjB:
3.02
1gmkD-1xnjB:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		5 / 11 LEU B 431
ALA B 429
LEU B 451
LEU B 449
SER B 416
 ADX  B2700 (-4.6A)
None
None
None
None
 1.26A 1ictA-1xnjB:
undetectable
1ictC-1xnjB:
undetectable		 1ictA-1xnjB:
11.43
1ictC-1xnjB:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		3 / 3 TRP B 457
HIS B 363
LYS B 367
 None
 1.30A 1l7xA-1xnjB:
2.7		 1l7xA-1xnjB:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		3 / 3 VAL B 512
ALA B 509
HIS B 506
 None
 0.77A 1q23C-1xnjB:
undetectable		 1q23C-1xnjB:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		3 / 3 VAL B 512
ALA B 509
HIS B 506
 None
 0.78A 1q23L-1xnjB:
undetectable		 1q23L-1xnjB:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		4 / 6 ASP B 394
THR B 399
GLU B 402
GLU B 272
 None
 1.16A 2dttB-1xnjB:
undetectable
2dttC-1xnjB:
undetectable		 2dttB-1xnjB:
11.24
2dttC-1xnjB:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		5 / 9 LEU B 338
LEU B 257
ILE B 259
PHE B 281
ILE B 377
 None
 1.07A 2f7aB-1xnjB:
1.0		 2f7aB-1xnjB:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		4 / 4 ALA B 417
VAL B 520
PHE B 418
THR B 435
 None
ADX  B2700 (-4.1A)
ADX  B2700 (-4.3A)
None
 1.42A 2pkkA-1xnjB:
2.3		 2pkkA-1xnjB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		4 / 5 GLU B 342
PRO B 341
ILE B 377
GLY B 378
 None
 0.94A 2qeuA-1xnjB:
undetectable
2qeuC-1xnjB:
1.5		 2qeuA-1xnjB:
12.87
2qeuC-1xnjB:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		5 / 12 SER B 305
ASN B 303
GLY B 542
ASP B 523
PHE B 418
 None
None
None
None
ADX  B2700 (-4.3A)
 1.45A 3a25A-1xnjB:
undetectable		 3a25A-1xnjB:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		4 / 8 SER B 133
PHE B 131
VAL B 116
LEU B  95
 None
ADX  B2805 (-4.6A)
None
None
 1.04A 3jq7C-1xnjB:
4.5		 3jq7C-1xnjB:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		3 / 3 SER B 587
GLY B 588
THR B 589
 None
 0.22A 3k9wA-1xnjB:
9.6		 3k9wA-1xnjB:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		3 / 3 GLY B  62
GLY B  64
THR B  66
 ADP  B2800 (-3.2A)
ADP  B2800 (-3.4A)
ADP  B2800 (-3.6A)
 0.44A 3si7B-1xnjB:
undetectable		 3si7B-1xnjB:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		4 / 8 TYR B 497
LEU B 454
GLY B 455
VAL B 262
 None
 0.86A 4c9nA-1xnjB:
undetectable		 4c9nA-1xnjB:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		5 / 12 CYH B 352
MET B 370
HIS B 346
LEU B 291
TYR B 287
 None
 1.08A 4emaA-1xnjB:
undetectable		 4emaA-1xnjB:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		4 / 8 THR B 204
ALA B 160
LEU B 162
VAL B 158
 ADP  B2800 (-4.1A)
None
None
None
 0.94A 4iizB-1xnjB:
undetectable		 4iizB-1xnjB:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		5 / 9 PHE B 281
ALA B 271
LEU B 270
GLY B 280
ALA B 498
 None
 1.22A 4l6va-1xnjB:
undetectable
4l6vf-1xnjB:
0.0		 4l6va-1xnjB:
21.36
4l6vf-1xnjB:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		3 / 3 HIS B  79
VAL B  55
LEU B 220
 None
 0.72A 4m2vA-1xnjB:
undetectable		 4m2vA-1xnjB:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		4 / 6 PHE B 605
MET B 572
ILE B 586
ARG B 590
 None
 1.35A 4mk4B-1xnjB:
3.3		 4mk4B-1xnjB:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		3 / 3 LEU B 476
LEU B 614
ASN B 426
 None
 0.72A 4otwA-1xnjB:
undetectable		 4otwA-1xnjB:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		4 / 5 LEU B 291
ALA B 353
VAL B 369
ILE B 366
 None
 0.98A 4xe3A-1xnjB:
undetectable		 4xe3A-1xnjB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		4 / 5 LEU B 291
ALA B 353
VAL B 369
ILE B 366
 None
 0.95A 4xe3B-1xnjB:
undetectable		 4xe3B-1xnjB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		4 / 4 CYH B 507
LEU B 552
LEU B 546
ALA B 549
 None
 0.60A 5hpuA-1xnjB:
undetectable
5hpuB-1xnjB:
undetectable		 5hpuA-1xnjB:
4.82
5hpuB-1xnjB:
4.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		4 / 4 VAL B  68
LEU B 200
ASN B 210
ASP B 208
 None
 1.26A 5vcyA-1xnjB:
undetectable		 5vcyA-1xnjB:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		4 / 4 PHE B 326
LEU B 270
LEU B 310
VAL B 383
 None
 1.34A 5xxiA-1xnjB:
undetectable		 5xxiA-1xnjB:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		5 / 12 MET B 264
ILE B 259
VAL B 383
LEU B 257
LEU B 320
 None
 1.14A 6b54A-1xnjB:
6.6		 6b54A-1xnjB:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1
(Homo
sapiens) 		4 / 8 GLN B 419
ALA B 513
VAL B 512
ARG B 510
 ADX  B2700 (-3.9A)
None
None
None
 1.03A 6hu9a-1xnjB:
undetectable
6hu9e-1xnjB:
0.6		 6hu9a-1xnjB:
19.00
6hu9e-1xnjB:
13.14