SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xnt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 1xnt PROTEIN (DNA-REPAIR
PROTEIN XRCC1)
(Homo
sapiens) 		4 / 6 LEU A 144
GLY A  64
SER A  14
CYH A 132
 None
 0.79A 3aiaA-1xntA:
undetectable		 3aiaA-1xntA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1xnt PROTEIN (DNA-REPAIR
PROTEIN XRCC1)
(Homo
sapiens) 		4 / 7 VAL A 128
LEU A  47
LEU A   6
ILE A  60
 None
 0.98A 3u5kB-1xntA:
undetectable		 3u5kB-1xntA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1xnt PROTEIN (DNA-REPAIR
PROTEIN XRCC1)
(Homo
sapiens) 		4 / 8 VAL A 128
LEU A  47
LEU A   6
ILE A  60
 None
 0.89A 3u5kC-1xntA:
undetectable		 3u5kC-1xntA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 1xnt PROTEIN (DNA-REPAIR
PROTEIN XRCC1)
(Homo
sapiens) 		4 / 5 VAL A 128
LEU A  47
LEU A   6
ILE A  60
 None
 0.94A 4a9jA-1xntA:
undetectable		 4a9jA-1xntA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 1xnt PROTEIN (DNA-REPAIR
PROTEIN XRCC1)
(Homo
sapiens) 		5 / 11 GLY A 143
GLY A  64
ASP A  63
ASN A  23
PRO A 141
 None
 0.91A 4dcmA-1xntA:
undetectable		 4dcmA-1xntA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1xnt PROTEIN (DNA-REPAIR
PROTEIN XRCC1)
(Homo
sapiens) 		3 / 3 ASP A  63
ASN A  23
SER A 140
 None
 0.76A 4obwA-1xntA:
undetectable		 4obwA-1xntA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 1xnt PROTEIN (DNA-REPAIR
PROTEIN XRCC1)
(Homo
sapiens) 		3 / 3 ASN A 106
SER A 145
ARG A  34
 None
 0.70A 5b2qA-1xntA:
undetectable		 5b2qA-1xntA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1xnt PROTEIN (DNA-REPAIR
PROTEIN XRCC1)
(Homo
sapiens) 		3 / 3 LYS A  32
LEU A   6
ILE A 130
 None
 0.60A 5kc0A-1xntA:
undetectable		 5kc0A-1xntA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1xnt PROTEIN (DNA-REPAIR
PROTEIN XRCC1)
(Homo
sapiens) 		3 / 3 LYS A  32
LEU A   6
ILE A 130
 None
 0.70A 5kc4A-1xntA:
undetectable		 5kc4A-1xntA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1xnt PROTEIN (DNA-REPAIR
PROTEIN XRCC1)
(Homo
sapiens) 		4 / 8 VAL A 128
LEU A  47
LEU A   6
ILE A  60
 None
 0.91A 5y1yA-1xntA:
undetectable		 5y1yA-1xntA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 1xnt PROTEIN (DNA-REPAIR
PROTEIN XRCC1)
(Homo
sapiens) 		5 / 12 VAL A  46
VAL A  72
GLY A  73
PHE A 149
VAL A 147
 None
 1.08A 6a94B-1xntA:
undetectable		 6a94B-1xntA:
19.83