SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xny'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ACJ_A_THAA999_1
(ACETYLCHOLINESTERASE)		 1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT
(Streptomyces
coelicolor) 		5 / 9 GLY A 220
GLU A 222
PHE A 204
HIS A 202
GLY A 226
 None
 1.41A 1acjA-1xnyA:
2.3		 1acjA-1xnyA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT
(Streptomyces
coelicolor) 		4 / 4 ILE A 336
LEU A 371
VAL A 411
ALA A 495
 None
 0.99A 1mz9A-1xnyA:
undetectable		 1mz9A-1xnyA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT
(Streptomyces
coelicolor) 		3 / 3 VAL A 236
ALA A 237
HIS A 239
 None
 0.70A 1q23C-1xnyA:
undetectable		 1q23C-1xnyA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT
(Streptomyces
coelicolor) 		3 / 3 VAL A 236
ALA A 237
HIS A 239
 None
 0.71A 1q23G-1xnyA:
undetectable		 1q23G-1xnyA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT
(Streptomyces
coelicolor) 		3 / 3 ARG A 393
ARG A 392
ILE A 528
 None
 0.77A 1uobA-1xnyA:
undetectable		 1uobA-1xnyA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT
(Streptomyces
coelicolor) 		4 / 6 TYR A 296
THR A 439
ALA A 440
PRO A 289
 None
 1.40A 2ql8A-1xnyA:
undetectable
2ql8B-1xnyA:
undetectable		 2ql8A-1xnyA:
15.57
2ql8B-1xnyA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT
(Streptomyces
coelicolor) 		4 / 7 GLY A 143
CYH A 180
PHE A 204
PHE A 221
 1VU  A5601 (-3.4A)
None
None
None
 1.02A 2qx4A-1xnyA:
2.3
2qx4B-1xnyA:
undetectable		 2qx4A-1xnyA:
20.58
2qx4B-1xnyA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT
(Streptomyces
coelicolor) 		4 / 8 TYR A 117
ARG A 162
MET A 125
ILE A 121
 None
 0.90A 2xytE-1xnyA:
undetectable		 2xytE-1xnyA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT
(Streptomyces
coelicolor) 		4 / 8 TYR A 117
ARG A 162
MET A 125
ILE A 121
 None
 0.86A 2xytH-1xnyA:
undetectable		 2xytH-1xnyA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT
(Streptomyces
coelicolor) 		4 / 8 ALA A  48
GLY A  32
GLY A  84
ASP A  85
 None
 0.65A 2yfxA-1xnyA:
undetectable		 2yfxA-1xnyA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT
(Streptomyces
coelicolor) 		4 / 6 VAL A 376
ASP A 422
TYR A 401
ASN A 339
 None
 1.43A 2zs9A-1xnyA:
undetectable		 2zs9A-1xnyA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT
(Streptomyces
coelicolor) 		5 / 12 THR A 191
VAL A 101
ALA A 100
VAL A 251
ILE A 121
 None
 0.95A 3dl9A-1xnyA:
undetectable		 3dl9A-1xnyA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT
(Streptomyces
coelicolor) 		5 / 11 VAL A 288
PRO A 289
ILE A 497
ILE A 412
PRO A 484
 None
 1.02A 3ganA-1xnyA:
0.0		 3ganA-1xnyA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT
(Streptomyces
coelicolor) 		3 / 3 ASP A 461
ARG A 457
ALA A 460
 None
 0.80A 3mbgC-1xnyA:
0.0		 3mbgC-1xnyA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT
(Streptomyces
coelicolor) 		4 / 7 VAL A 329
VAL A 368
ILE A 336
ARG A 508
 None
 1.33A 3ms9B-1xnyA:
undetectable		 3ms9B-1xnyA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT
(Streptomyces
coelicolor) 		3 / 3 ASP A  85
GLU A 115
GLY A 114
 None
 0.62A 3w9tA-1xnyA:
undetectable		 3w9tA-1xnyA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT
(Streptomyces
coelicolor) 		5 / 12 LYS A  45
ASP A 105
GLY A 110
LEU A 113
ASP A 140
 None
None
1VU  A5601 ( 4.2A)
None
None
 1.12A 4blvB-1xnyA:
undetectable		 4blvB-1xnyA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT
(Streptomyces
coelicolor) 		3 / 3 HIS A 505
VAL A 334
LEU A 510
 None
 0.75A 4m2vA-1xnyA:
undetectable		 4m2vA-1xnyA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT
(Streptomyces
coelicolor) 		5 / 12 VAL A 185
ALA A 184
TYR A 186
GLY A 207
GLY A 143
 None
None
None
None
1VU  A5601 (-3.4A)
 1.21A 4mm8A-1xnyA:
undetectable		 4mm8A-1xnyA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT
(Streptomyces
coelicolor) 		5 / 11 VAL A 185
ALA A 184
TYR A 186
GLY A 207
GLY A 143
 None
None
None
None
1VU  A5601 (-3.4A)
 1.15A 4mm9A-1xnyA:
undetectable		 4mm9A-1xnyA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT
(Streptomyces
coelicolor) 		4 / 6 TYR A 485
ILE A 412
VAL A 496
ALA A 436
 None
 0.82A 5cu6A-1xnyA:
undetectable		 5cu6A-1xnyA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT
(Streptomyces
coelicolor) 		4 / 7 ALA A 402
GLY A 430
SER A 426
GLY A 425
 None
 0.78A 5e26A-1xnyA:
undetectable
5e26B-1xnyA:
undetectable		 5e26A-1xnyA:
22.57
5e26B-1xnyA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT
(Streptomyces
coelicolor) 		4 / 7 GLY A 430
SER A 426
GLY A 425
ALA A 402
 None
 0.82A 5e26C-1xnyA:
undetectable
5e26D-1xnyA:
undetectable		 5e26C-1xnyA:
22.57
5e26D-1xnyA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT
(Streptomyces
coelicolor) 		5 / 11 ILE A 170
CYH A 133
ALA A 128
PHE A 102
LEU A 129
 None
 1.27A 5hw4B-1xnyA:
undetectable		 5hw4B-1xnyA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT
(Streptomyces
coelicolor) 		5 / 12 GLY A 137
VAL A 135
VAL A  99
TYR A 117
VAL A  88
 None
 1.21A 5n0wA-1xnyA:
undetectable		 5n0wA-1xnyA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT
(Streptomyces
coelicolor) 		3 / 3 PHE A 359
ASP A 192
LEU A 530
 None
 0.80A 5uhbC-1xnyA:
undetectable		 5uhbC-1xnyA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT
(Streptomyces
coelicolor) 		5 / 12 ARG A  51
ASN A 139
VAL A  87
ASP A 105
GLY A 111
 None
 1.11A 5x24A-1xnyA:
undetectable		 5x24A-1xnyA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_A_CP6A704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT
(Streptomyces
coelicolor) 		5 / 10 ALA A 352
ASP A 349
PHE A 379
VAL A 423
THR A 351
 None
None
BTN  A5602 (-4.8A)
None
None
 1.37A 6aogA-1xnyA:
undetectable		 6aogA-1xnyA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_B_CP6B704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1xny PROPIONYL-COA
CARBOXYLASE COMPLEX
B SUBUNIT
(Streptomyces
coelicolor) 		5 / 10 ALA A 352
ASP A 349
PHE A 379
VAL A 423
THR A 351
 None
None
BTN  A5602 (-4.8A)
None
None
 1.35A 6aogB-1xnyA:
undetectable		 6aogB-1xnyA:
8.67