SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xoc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		5 / 11 LEU A 214
LEU A 201
ALA A 157
VAL A 217
LEU A 510
 None
 1.34A 1kt6A-1xocA:
undetectable		 1kt6A-1xocA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		4 / 8 ALA A 494
ASP A 236
ILE A 237
ILE A 222
 None
 0.79A 1p7lD-1xocA:
undetectable		 1p7lD-1xocA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		4 / 8 ALA A 494
ASP A 236
ILE A 237
ILE A 222
 None
 0.80A 1p7lC-1xocA:
undetectable		 1p7lC-1xocA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		4 / 8 ALA A 494
ASP A 236
ILE A 237
ILE A 222
 None
 0.78A 1rg9B-1xocA:
undetectable		 1rg9B-1xocA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		4 / 8 ALA A 494
ASP A 236
ILE A 237
ILE A 222
 None
 0.78A 1rg9A-1xocA:
undetectable		 1rg9A-1xocA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		4 / 8 ALA A 494
ASP A 236
ILE A 237
ILE A 222
 None
 0.79A 1rg9D-1xocA:
undetectable		 1rg9D-1xocA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		4 / 8 ALA A 494
ASP A 236
ILE A 237
ILE A 222
 None
 0.81A 1rg9C-1xocA:
undetectable		 1rg9C-1xocA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		5 / 12 ILE A 158
ALA A 100
SER A  72
ILE A  73
LEU A 153
 None
 1.18A 1rx3A-1xocA:
undetectable		 1rx3A-1xocA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		4 / 5 GLU A 294
THR A 484
LEU A 291
LEU A 486
 None
 1.16A 1u18B-1xocA:
undetectable		 1u18B-1xocA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		5 / 12 ALA A 225
GLY A  27
ILE A  29
LEU A  24
TYR A 502
 None
 1.09A 1x1aA-1xocA:
undetectable		 1x1aA-1xocA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		4 / 7 TYR A 266
TYR A 483
GLY A 418
ASP A  47
 None
None
None
ZN  A 533 (-2.4A)
 1.11A 2g72B-1xocA:
undetectable		 2g72B-1xocA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		5 / 9 LEU A  38
TYR A  39
THR A 156
ALA A 157
LEU A  34
 None
 1.24A 2npnA-1xocA:
undetectable		 2npnA-1xocA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		5 / 12 ILE A 158
ALA A 100
SER A  72
ILE A  73
LEU A 153
 None
 1.13A 3ia4B-1xocA:
undetectable		 3ia4B-1xocA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		5 / 12 ILE A 158
ALA A 100
SER A  72
ILE A  73
LEU A 153
 None
 1.13A 3ia4D-1xocA:
undetectable		 3ia4D-1xocA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		5 / 12 GLU A 514
GLY A 186
VAL A  26
PHE A  55
ILE A 513
 None
 0.99A 3k13A-1xocA:
undetectable		 3k13A-1xocA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		4 / 8 TYR A  39
SER A 112
LEU A 172
ASP A 171
 None
None
None
ZN  A 526 ( 2.9A)
 1.07A 3lsfH-1xocA:
undetectable		 3lsfH-1xocA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		5 / 12 ASN A 150
ILE A 158
PHE A 139
ILE A  73
TYR A  82
 None
 1.10A 3q5pA-1xocA:
undetectable		 3q5pA-1xocA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		5 / 11 THR A 484
LEU A 364
THR A 393
VAL A 391
LEU A 291
 None
 1.21A 3tbgA-1xocA:
undetectable		 3tbgA-1xocA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		4 / 8 GLN A 394
VAL A 396
ASP A 411
GLN A 404
 None
 0.88A 3uy4A-1xocA:
undetectable		 3uy4A-1xocA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		5 / 8 ILE A  48
ILE A 199
VAL A 221
GLN A 195
GLY A 196
 None
 1.31A 4ac9C-1xocA:
2.4		 4ac9C-1xocA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		3 / 3 PHE A 485
VAL A 380
ILE A 376
 None
 0.47A 4emaA-1xocA:
undetectable		 4emaA-1xocA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		5 / 12 ILE A 158
ALA A 100
SER A  72
ILE A  73
LEU A 153
 None
 1.17A 4gh8A-1xocA:
undetectable		 4gh8A-1xocA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		4 / 4 TYR A 107
THR A  57
VAL A  84
ILE A 158
 None
 1.26A 4jx1F-1xocA:
undetectable		 4jx1F-1xocA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		4 / 8 ALA A 494
ASP A 236
ILE A 237
ILE A 222
 None
 0.87A 4kttB-1xocA:
undetectable		 4kttB-1xocA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		4 / 8 ALA A 494
ASP A 236
ILE A 237
ILE A 222
 None
 0.81A 4kttD-1xocA:
undetectable		 4kttD-1xocA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		3 / 3 ARG A 119
LEU A 440
GLU A 118
 None
None
ZN  A 530 (-2.3A)
 0.75A 4l3gF-1xocA:
undetectable		 4l3gF-1xocA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		4 / 8 ALA A 494
ASP A 236
ILE A 237
ILE A 222
 None
 0.88A 4ndnB-1xocA:
undetectable		 4ndnB-1xocA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		4 / 8 ALA A 494
ASP A 236
ILE A 237
ILE A 222
 None
 0.88A 4ndnD-1xocA:
undetectable		 4ndnD-1xocA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		4 / 6 PHE A 105
TYR A  53
PHE A 177
ASN A 175
 None
 1.28A 4o7gB-1xocA:
undetectable		 4o7gB-1xocA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		3 / 3 ALA A 457
GLN A 435
GLY A 439
 None
 0.61A 4odoC-1xocA:
undetectable		 4odoC-1xocA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		5 / 12 ILE A 158
ALA A 100
SER A  72
ILE A  73
LEU A 153
 None
 1.08A 4qi9A-1xocA:
undetectable		 4qi9A-1xocA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		5 / 12 ILE A 158
ALA A 100
SER A  72
ILE A  73
LEU A 153
 None
 1.11A 4qi9B-1xocA:
undetectable		 4qi9B-1xocA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		5 / 11 ILE A 158
ALA A 100
SER A  72
ILE A  73
LEU A 153
 None
 1.12A 4qi9C-1xocA:
undetectable		 4qi9C-1xocA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		5 / 11 ILE A 158
ALA A 100
SER A  72
ILE A  73
LEU A 153
 None
 1.15A 4qleB-1xocA:
undetectable		 4qleB-1xocA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB302_1
(CHITOSANASE)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		4 / 5 GLU A 312
TYR A 266
ILE A 430
TYR A 470
 None
 1.34A 4qwpB-1xocA:
0.0		 4qwpB-1xocA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		3 / 5 GLY A 439
GLY A 120
GLU A 124
 None
 0.47A 4z2eA-1xocA:
4.4
4z2eD-1xocA:
undetectable		 4z2eA-1xocA:
20.72
4z2eD-1xocA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		5 / 12 ILE A 158
ALA A 100
SER A  72
ILE A  73
LEU A 153
 None
 1.12A 5hi6A-1xocA:
undetectable		 5hi6A-1xocA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		5 / 12 ILE A 158
ALA A 100
SER A  72
ILE A  73
LEU A 153
 None
 1.16A 5hi6B-1xocA:
undetectable		 5hi6B-1xocA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		5 / 11 LEU A 486
TYR A 487
ARG A 293
ILE A 376
VAL A 379
 None
 1.21A 5hjiA-1xocA:
undetectable		 5hjiA-1xocA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		3 / 3 TYR A 135
TYR A 207
SER A 185
 None
 0.77A 5iktB-1xocA:
undetectable		 5iktB-1xocA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		4 / 5 VAL A 372
THR A 245
ASP A 304
LEU A 301
 None
None
ZN  A 523 (-2.1A)
None
 1.01A 5m0iB-1xocA:
undetectable		 5m0iB-1xocA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		3 / 3 THR A 366
THR A 484
LEU A 384
 None
 0.60A 5m66D-1xocA:
undetectable		 5m66D-1xocA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		4 / 5 ILE A  86
PHE A 208
SER A  54
ALA A  70
 None
 1.20A 5msdA-1xocA:
undetectable		 5msdA-1xocA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		5 / 10 ARG A 211
ALA A 203
GLY A 210
ILE A 163
LEU A 164
 None
 1.08A 5oy01-1xocA:
undetectable
5oy07-1xocA:
undetectable		 5oy01-1xocA:
9.69
5oy07-1xocA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		4 / 8 ALA A 494
ASP A 236
ILE A 237
ILE A 222
 None
 0.82A 5t8sA-1xocA:
undetectable		 5t8sA-1xocA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		4 / 5 GLY A 146
ARG A 463
ASP A 145
GLN A 435
 None
 1.50A 5ubbA-1xocA:
undetectable		 5ubbA-1xocA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		5 / 12 ILE A 183
LEU A  98
LEU A  52
ASN A 204
ALA A 157
 None
 1.15A 6qxsD-1xocA:
undetectable		 6qxsD-1xocA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		5 / 12 ILE A 183
LEU A  98
LEU A  52
ASN A 204
ALA A 157
 None
 1.06A 6r2eE-1xocA:
0.0		 6r2eE-1xocA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 1xoc OLIGOPEPTIDE-BINDING
PROTEIN APPA
(Bacillus
subtilis) 		5 / 11 ILE A 183
LEU A  98
LEU A  52
ASN A 204
ALA A 157
 None
 1.12A 6r2eF-1xocA:
undetectable		 6r2eF-1xocA:
19.55