SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1xp3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		5 / 12 THR A 261
HIS A 230
HIS A 183
VAL A 109
TYR A  34
 None
SO4  A 304 (-3.3A)
ZN  A 302 (-3.2A)
None
None
 1.29A 1j36A-1xp3A:
undetectable		 1j36A-1xp3A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		5 / 12 THR A 261
HIS A 230
HIS A 183
VAL A 109
TYR A  34
 None
SO4  A 304 (-3.3A)
ZN  A 302 (-3.2A)
None
None
 1.29A 1j36B-1xp3A:
undetectable		 1j36B-1xp3A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		5 / 12 ILE A 127
LEU A 131
VAL A 134
ILE A 143
ILE A 165
 None
 0.96A 1oipA-1xp3A:
undetectable		 1oipA-1xp3A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_A_BEZA881_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		5 / 11 LEU A 259
TYR A 240
ILE A 233
HIS A 244
HIS A 248
 None
 1.48A 1tmxA-1xp3A:
undetectable		 1tmxA-1xp3A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		5 / 12 LEU A 259
TYR A 240
ILE A 233
HIS A 244
HIS A 248
 None
 1.39A 1tmxB-1xp3A:
undetectable		 1tmxB-1xp3A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		4 / 8 GLU A 260
HIS A 230
ASP A 180
HIS A 215
 ZN  A 303 ( 2.6A)
SO4  A 304 (-3.3A)
ZN  A 303 ( 3.3A)
ZN  A 303 (-3.5A)
 0.98A 1v7zD-1xp3A:
undetectable		 1v7zD-1xp3A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		4 / 8 GLU A 260
HIS A 230
ASP A 180
HIS A 215
 ZN  A 303 ( 2.6A)
SO4  A 304 (-3.3A)
ZN  A 303 ( 3.3A)
ZN  A 303 (-3.5A)
 0.98A 1v7zE-1xp3A:
undetectable		 1v7zE-1xp3A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		5 / 8 TYR A 189
GLY A 156
GLY A 150
ALA A 187
ALA A 149
 None
 1.41A 2ej3C-1xp3A:
undetectable		 2ej3C-1xp3A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		4 / 7 HIS A 244
ASP A 218
THR A 286
GLY A 285
 None
 1.05A 2f6dA-1xp3A:
undetectable		 2f6dA-1xp3A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		5 / 11 ASP A 180
HIS A 183
HIS A 111
HIS A 230
HIS A   7
 ZN  A 303 ( 3.3A)
ZN  A 302 (-3.2A)
ZN  A 301 ( 3.4A)
SO4  A 304 (-3.3A)
None
 1.26A 2q0jB-1xp3A:
undetectable		 2q0jB-1xp3A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		5 / 11 ILE A 238
LEU A 214
LEU A 243
ILE A 216
THR A 261
 None
 1.04A 3a50B-1xp3A:
undetectable		 3a50B-1xp3A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		5 / 11 ILE A 238
LEU A 214
LEU A 243
ILE A 216
THR A 261
 None
 1.00A 3a50C-1xp3A:
undetectable		 3a50C-1xp3A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		5 / 12 ILE A 238
LEU A 214
LEU A 243
ILE A 216
THR A 261
 None
 0.94A 3a50E-1xp3A:
undetectable		 3a50E-1xp3A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		4 / 8 GLU A 260
HIS A 230
ASP A 180
HIS A 215
 ZN  A 303 ( 2.6A)
SO4  A 304 (-3.3A)
ZN  A 303 ( 3.3A)
ZN  A 303 (-3.5A)
 0.96A 3a6jE-1xp3A:
undetectable		 3a6jE-1xp3A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EQM_A_ASDA601_1
(CYTOCHROME P450 19A1)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		5 / 10 ILE A 191
PHE A 195
ASP A 180
THR A 147
LEU A 214
 None
None
ZN  A 303 ( 3.3A)
None
None
 1.10A 3eqmA-1xp3A:
0.0		 3eqmA-1xp3A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		4 / 6 ILE A   4
TYR A 275
ILE A 233
HIS A 244
 None
 1.18A 3eteA-1xp3A:
undetectable
3eteE-1xp3A:
undetectable		 3eteA-1xp3A:
20.76
3eteE-1xp3A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		4 / 5 ILE A   4
TYR A 275
ILE A 233
HIS A 244
 None
 1.15A 3eteB-1xp3A:
undetectable
3eteC-1xp3A:
undetectable		 3eteB-1xp3A:
20.76
3eteC-1xp3A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		4 / 7 ILE A 233
HIS A 244
ILE A   4
TYR A 275
 None
 1.17A 3eteD-1xp3A:
undetectable
3eteF-1xp3A:
undetectable		 3eteD-1xp3A:
20.76
3eteF-1xp3A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		5 / 12 GLY A  77
GLY A  88
ALA A 114
LEU A 110
ILE A  74
 None
 1.02A 3ku1H-1xp3A:
undetectable		 3ku1H-1xp3A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		4 / 5 HIS A   7
GLU A 260
HIS A  69
HIS A 111
 None
ZN  A 303 ( 2.6A)
ZN  A 301 (-3.4A)
ZN  A 301 ( 3.4A)
 1.12A 3lkaA-1xp3A:
undetectable		 3lkaA-1xp3A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		5 / 12 ILE A 127
ILE A 128
LEU A 131
ALA A 163
VAL A 169
 None
 0.65A 3rukB-1xp3A:
undetectable		 3rukB-1xp3A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S79_A_ASDA601_1
(CYTOCHROME P450 19A1)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		5 / 12 ILE A 191
PHE A 195
ASP A 180
THR A 147
LEU A 214
 None
None
ZN  A 303 ( 3.3A)
None
None
 1.11A 3s79A-1xp3A:
undetectable		 3s79A-1xp3A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		3 / 3 GLN A 139
GLU A 173
LYS A 174
 None
 1.09A 3su9A-1xp3A:
undetectable		 3su9A-1xp3A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		4 / 7 HIS A   7
ILE A  33
PRO A  38
HIS A  69
 None
None
None
ZN  A 301 (-3.4A)
 1.19A 4g5jA-1xp3A:
undetectable		 4g5jA-1xp3A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		4 / 8 ILE A 143
LEU A 131
ILE A 162
GLY A  77
 None
 0.83A 4hb8A-1xp3A:
undetectable		 4hb8A-1xp3A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		3 / 3 THR A 261
HIS A 249
LEU A 214
 None
 0.81A 5axdC-1xp3A:
undetectable		 5axdC-1xp3A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		5 / 12 TYR A  34
HIS A 183
PRO A 262
ASP A 180
ASN A 217
 None
ZN  A 302 (-3.2A)
None
ZN  A 303 ( 3.3A)
None
 1.38A 5dv4A-1xp3A:
undetectable		 5dv4A-1xp3A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		5 / 12 GLY A 226
GLY A 188
ASP A 190
SER A 219
HIS A 237
 None
 1.20A 5hikA-1xp3A:
undetectable		 5hikA-1xp3A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		4 / 6 ILE A  67
GLY A  54
MET A  58
ILE A  33
 None
 0.96A 5j4nB-1xp3A:
undetectable		 5j4nB-1xp3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		5 / 12 ILE A 191
PHE A 195
ASP A 180
THR A 147
LEU A 214
 None
None
ZN  A 303 ( 3.3A)
None
None
 1.07A 5jkvA-1xp3A:
undetectable		 5jkvA-1xp3A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		5 / 11 ILE A 191
PHE A 195
ASP A 180
THR A 147
LEU A 214
 None
None
ZN  A 303 ( 3.3A)
None
None
 1.15A 5jkwA-1xp3A:
undetectable		 5jkwA-1xp3A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JL7_A_ASDA601_1
(AROMATASE)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		5 / 10 ILE A 191
PHE A 195
ASP A 180
THR A 147
LEU A 214
 None
None
ZN  A 303 ( 3.3A)
None
None
 1.16A 5jl7A-1xp3A:
0.0		 5jl7A-1xp3A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		4 / 6 HIS A  69
ASP A 180
HIS A 183
HIS A 215
 ZN  A 301 (-3.4A)
ZN  A 303 ( 3.3A)
ZN  A 302 (-3.2A)
ZN  A 303 (-3.5A)
 1.08A 5nelB-1xp3A:
3.1
5nelC-1xp3A:
3.5		 5nelB-1xp3A:
22.51
5nelC-1xp3A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		5 / 12 LEU A 199
PHE A 179
ILE A 279
LEU A 282
ILE A 246
 None
 1.20A 5y2tB-1xp3A:
0.0		 5y2tB-1xp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		5 / 11 HIS A 111
HIS A 230
ASN A 217
HIS A 183
HIS A 215
 ZN  A 301 ( 3.4A)
SO4  A 304 (-3.3A)
None
ZN  A 302 (-3.2A)
ZN  A 303 (-3.5A)
 1.09A 5z0fA-1xp3A:
undetectable
5z0fB-1xp3A:
undetectable		 5z0fA-1xp3A:
12.42
5z0fB-1xp3A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		5 / 11 HIS A 111
HIS A 230
ASN A 217
HIS A 183
HIS A 215
 ZN  A 301 ( 3.4A)
SO4  A 304 (-3.3A)
None
ZN  A 302 (-3.2A)
ZN  A 303 (-3.5A)
 1.07A 5z0gA-1xp3A:
undetectable
5z0gB-1xp3A:
undetectable		 5z0gA-1xp3A:
12.42
5z0gB-1xp3A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		5 / 9 ALA A 163
ILE A 162
PHE A 179
PHE A 202
SER A 176
 None
 1.36A 6awoA-1xp3A:
undetectable		 6awoA-1xp3A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		5 / 9 ALA A 163
ILE A 162
PHE A 179
PHE A 202
SER A 176
 None
 1.36A 6awqA-1xp3A:
undetectable		 6awqA-1xp3A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 1xp3 ENDONUCLEASE IV
(Bacillus
anthracis) 		5 / 12 ASN A 217
PRO A 262
VAL A 264
ILE A 216
ILE A 295
 None
 1.23A 6j20A-1xp3A:
0.0		 6j20A-1xp3A:
19.51